"Here, we introduce POND-seq (protein nanocage-empowered non-destructive sequencing), a strategy that employs secretory protein nanocages fused to RNA-binding proteins (RBPs) to recover RBP-associated RNAs from living cells" www.cell.com/molecular-ce...

Longitudinal monitoring of cytoplasmic RBP-RNA interactions and transcriptome in living cells by engineered protein nanocages

Hu et al. develop POND-seq, a nanocage-based strategy that exports RNA information from living cells without disruption. This approach enables repeated sampling of the same cell population to track tr...

cell.com

The final keynote lecture of the 6th Virtual ChemBioTalks will be given by Michelle Chang (@mchanggroup.bsky.social). She will talk about: "Discovery and engineering of new enzymes for biocatalysis" Register for free: events.zoom.us/ev/Ag... #ChemBio #Chemsky Chemistry Europe

These two reviews on centromeres and kinetochores in @natrevmcb.nature.com cap off @andrea-musacchio.bsky.social sabbatical at @stanfordbiochem.bsky.social from @valleefoundation.bsky.social. Long time in the making! Non-paywall versions rdcu.be/fxD9V, rdcu.be/fxEar

Structure and function of the centromere and inner kinetochore

Nature Reviews Molecular Cell Biology - The kinetochore is a macromolecular complex that assembles on centromeric chromatin and connects spindle microtubules to the chromosome. This Review...

rdcu.be

Aging disrupts tissue homeostasis via mesenchymal drift, where cells lose identity and gain mesenchymal traits, linking 6 key hallmarks and creating a feedback loop. PMID:42208498, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00455-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...

Analog intrinsic recoding measures RNA dynamics without chemical conversion

Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...

biorxiv.org

A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins doi.org/10.1093/nar/...

A multivalent RNA affinity tag enables selective purification of tagged RNAs and bound proteins

Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz

doi.org

Run Openfold3 on my laptop machine #openfold3 #co-folding #informatics Recently several co-folding AI are available, for example AF3, Chai-1, protenix and openfold. This area is hot and growing day by day. Co-Folding AI has potential for taking SBDD approach without determining the target…

Run Openfold3 on my laptop machine #openfold3 #co-folding #informatics

Recently several co-folding AI are available, for example AF3, Chai-1, protenix and openfold. This area is hot and growing day by day. Co-Folding AI has potential for taking SBDD approach without determining the target protein-ligand structure. As most of readers know that there are still limitation of using co-folding AI for SBDD but really useful I think. I have an interest in openfold because openfold disclose code and has good open scientific community.

iwatobipen.wordpress.com

A new AI-based program, dubbed Raygun, can suggest strategic cuts to a protein’s amino acid sequence to shrink the overall structure without affecting the protein’s function: cen.acs.org/physical-che... #chemsky 🧪

Chronicle of Higher Education article on the Kratsios "Golden Age of Science" document www.chronicle.com/article/why-... “This whole document really strikes me as being incredibly naïve and just wrong,” said Jeremy Berg, who led ... a branch of the (NIH), during the Bush and Obama administrations.

Why Scientists Hate Trump’s New Plan to Revamp Research Funding

Diverting money from universities would distort priorities and slow discovery, they say.

chronicle.com

Quantifying Ternary Complex Stability Through Binding Free Energy Calculations in the Geometric Route chemrxiv.org/doi/pdf/10.2...

Scientists have exploited a peculiar CRISPR enzyme so that it fights cancer by shredding the DNA in cancer cells, causing them to self-destruct go.nature.com/4pKLI6X

Bizarre CRISPR enzyme kills cancer cells by shredding their DNA

Early tests suggest the protein can be aimed at targets with tumour-causing mutations.

go.nature.com

This I think has been the goal of examining models that can regenerate - that gene regulatory networks are there to do these things even in organisms that don’t see to have the ability

Margarita Parada-Kusz@margaritapk.bsky.social · 2w ago

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch www.science.org/doi/10.1126/...

A pioneering study achieves whole-body spatiotranscriptomics in mice, revealing 379 cell types from 59M single cells, enhancing biomedical research and machine learning applications. PMID:41903540, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00273-4 #Medsky #Pharmsky #RNA 🧪

📢 Don't miss your chance to register for the 10th RSC BMCS Fragment-based Drug Discovery Meeting happening from 14-16th September in Cambridge at Churchill College, University of Cambridge! #Fragments2026 ➡️ Find out more and register here! www.rscbmcs.org/even... www.eventsforce.net/...

A study of 311 brain samples reveals that somatic variants in cancer driver genes, particularly linked to clonal hematopoiesis, are enriched in Alzheimer's microglia-like cells, driving inflammation and… PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #RNA 🧪

RNA flexible? Maybe we can model that. First blind test of RNA 3D *ensemble* prediction — ligand-free SAMURI ribozyme (displayed on a group II intron scaffold) -- #MD and #deeplearning methods welcome, deadline Aug 22, 2026: predictioncenter.org/casp17/targe...

My lab at #Yale has two #riboswitch research openings: 1. Postdoc with mammalian gene manipulation experience (tinyurl.com/zzb269em); 2. Postdoc (or BS, MS) with bioinformatics skills (tinyurl.com/3j73jfcn). Send your cv to me or to Kavita at kumari.thakur@yale.edu.

Wait, what?! This isn’t about ribosomes? Check out our new work where we find that a #Legionella effector thought to target host translation instead targets metabolism by modifying a host glycolytic metabolite. Led by @drjoshblack.bsky.social www.cell.com/molecular-ce...

The Legionella pneumophila effector SidL is an adenylyltransferase that modifies the glycolytic intermediate 3-phosphoglycerate

Black et al. identify the L. pneumophila effector SidL as an adenylyltransferase that targets host glycolysis. SidL covalently modifies the glycolytic intermediate 3-phosphoglycerate (3PG) with AMP, g...

cell.com

New post up at Inverse Square & Balloon Juice on the planned grift with which the Trump administration would dismantle US science. Shout out to @jtimmer.bsky.social and @dereklowe.bsky.social for their excellent takes on the same subject. (Balloon Juice link: balloon-juice.com/2026/07/24/t...)

Trump Grift Comes For US Science

The White House plan for the future of US science policy is a mafia bust-out plan

tomlevenson.substack.com

A genome-scale map of genetic interactions in HAP1 cells reveals ~89,000 high-confidence interactions, linking genes to protein complexes and advancing gene co-essentiality insights. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA 🧪

Caroline Langley's primary thesis chapter from her time as a grad student in @memerman.bsky.social's and my lab is now published. She shows that HIV-1 Vif’s ability to maintain A3G antagonism depends on structural robustness, which permits adaptation, and epistasis, which imposes constraints.

@JohnGrossSF@johngrosssf.bsky.social · 2w ago

Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins | Science Advances www.science.org/doi/10.1126/... Congratulations on this beautiful work!

New method SAMENT labels immune-excluded niches in metastatic cancer, revealing common traits like macrophage enrichment & T cell depletion across models and organs. 🌟 PMID:42054994, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00398-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Biomolecular condensates can function as inherent catalysts: Molecular Cell www.cell.com/molecular-ce...

Biomolecular condensates can function as inherent catalysts

Chen, Guo, Farag, Qian et al. present that biomolecular condensates formed by proteins lacking catalytic activity can mediate diverse hydrolysis reactions, highlighting the importance of condensate el...

cell.com

David Puleo, Marina Nelen, Chinatsu Sakata, and Ryan Potts discussed "Degraders in the Era of Precision Oncology" in an #AACRdrugdev26 plenary session chaired by Danette Daniels. @danetteldaniels.bsky.social @pottslab.bsky.social

TEAD1 forms large, inactive nuclear condensates on pericentromeric heterochromatin in cancer cells, challenging prior roles in transcription. PMID:42277434, Nat Cell Biol 2026, @NatureCellBio https://doi.org/10.1038/s41556-026-01985-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells | Nature Cell Biology

TEA domain transcription factor 1 (TEAD1), a Hippo pathway transcription factor important in cellular homeostasis and development, is increasingly implicated in cancer biology. Here we reveal an unexpected role for TEAD1 in organizing nuclear condensates, independent of active transcription. Using high-resolution imaging, ChIP–seq, RNA sequencing and proximity-based proteomics, we demonstrate that in patient-derived renal cell carcinoma cells, TEAD1 forms micrometre-sized condensates by binding to heterochromatic pericentromeric regions using its DNA-binding domain. TEAD-specific MCAT motifs selectively enrich and cluster in the pericentromeric region to specifically seed TEAD1 condensates. TEAD1 condensates do not activate transcription but instead serve as depots for excess TEAD1, and disruption of TEAD1 condensates leads to increases in YAP and TEAD target gene expression. This organization of TEAD1 contrasts with that observed in other genomic regions of both renal cell carcinoma a

doi.org

Glad that our deposited datasets are serving their intended purpose. It will be interesting to see how much the interpretability of the ligands has improved once the maps are available for inspection.

Structura Biotechnology@structurabio.bsky.social · 2w ago

🚀 Can automation solve preferred orientation in your #cryoEM datasets? After automating processing across 21 GPCR datasets in #CryoSPARC, we updated the workflow to be even more robust to preferred orientation, achieving improved map quality over manual processing. Read more 👉 bit.ly/3RyOIGG

In their Tools and Resources article, Ranran Mao, Jia-Jia Liu @rainier2009.bsky.social and colleagues present their new split GFP-based biosensors for detecting ER-Golgi membrane contact dynamics. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

These data will be important in future clinical development of BTK degraders and considering new modalities to target. Thank you to @bloodcancerunited.bsky.social, @ascocancer.bsky.social, @mskcancercenter.bsky.social, NCI, and the CLL Society for their support.

Der Klaus-Grohe-Preis 2026 geht erstmals an zwei Forscher: Edward Tate (London) macht Fettmoleküle zum Werkzeug gegen Krebs, Nicolas Winssinger (Genf) baut schaltbare Wirkstoffe aus Nukleinsäuren: www.gdch.app/article/klaus-grohe-preis-2026-erstmals-an-zwei-forscher-2026-07

Delighted to see the latest preprint progress to publication with Advanced Science. We built the protein FRET ruler as a bridge between biophysicists and cell biologists - realising the potential of FRET link measurements from molecules to cells. advanced.onlinelibrary.wiley.com/doi/10.1002/...