Tobi Alegbe
@tobioinformatics.bsky.social
I look at small things on a big scale Single-cell data scientist at Open Targets, EMBL-EBI. Previously StatGen PhD student at Sanger Institute
6 years 646 patients 1193 samples 100 endoscopists 9 lab scientists 3 postdocs 2 PhD students 502 courier runs from Addenbrooke’s Hospital to @sangerinstitute.bsky.social IBDverse is the largest single-cell dataset of Inflammatory Bowel Disease (IBD)—and generating the data for it was no mean feat
Out now in Nature Genetics! The largest single-cell RNA sequencing dataset of terminal ileal biopsies profiles 1.1 million cells from over 100 Crohn’s disease patients and over 200 healthy controls. Crohn’s disease is a type of inflammatory bowel disease (IBD) www.nature.com/articles/s41...
Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn’s disease pathogenesis - Nature Genetics
IBDverse is a single-cell RNA atlas of terminal ileal biopsies comprising 1.1 million cells from 111 patients with Crohn’s disease and 232 healthy participants. Analysis of the data identifies genes, ...
nature.com
Gothenburg airport currently flaunting the longest line of geneticists in the world. @pacbio.bsky.social can you beat this on Sunday? #ESHG2026
Delighted to see this out, check out my pinned post for a run through of the findings from when it was a preprint!
Nature@nature.com · 2mo agoNature research paper: Cell-type-resolved genetic variation shapes inflammatory bowel disease risk go.nature.com/4o3hSJS
Very privileged to have played a small part in this single cell eqtl study of intestinal and blood cells. Led by the fabulous @carlanderson.bsky.social @tobioinformatics.bsky.social @bradleyomics.bsky.social.
Nature@nature.com · 2mo agoNature research paper: Cell-type-resolved genetic variation shapes inflammatory bowel disease risk go.nature.com/4o3hSJS
Now published! Our paper on: (1) Accurate sequencing of sperm at scale (2) Positive selection of spermatogenesis driver mutations across the exome (3) Offspring disease risks from male reproductive aging [1/n] www.nature.com/articles/s41...
Sperm sequencing reveals extensive positive selection in the male germline - Nature
A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.
nature.com
Happy to share that this work together with @opentargets.org is now out at Nature Communications.
Open Targets@opentargets.org · 10mo agoOut now in Nature Comms: the largest trans-eQTL meta-analysis in a single cell type! An Open Targets team led by Krista Freimann and @kauralasoo.bsky.social analysed 3,734 lymphoblastoid cell line samples across nine cohorts, identifying four robust loci www.nature.com/articles/s41...
Scientists have uncovered hidden genetic drivers of conditions like IBD by stimulating immune cells. 🔬 The findings have resulted in a dataset called MacroMap, which offers insight into why some people are vulnerable to certain conditions. sanger.ac.uk/news_item/ac...
Activated immune cells reveal hidden drivers of autoimmune diseases
A new resource, MacroMap, provides a rich dataset that researchers can use to explore genetic mechanisms behind complex diseases.
sanger.ac.uk
🚨New preprint just dropped 🚨 medrxiv.org/content/10.1101/2025.06.24.25330216 The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!
An awesome preprint by a superstar PhD student looking at the utility of blood vs tissue in the context of disease!
Lucia Ramirez-Navarro@luciaramirez.bsky.social · last yr.🚨 SUPER EXCITED to share our new preprint on the mucosal and circulatory immune landscape of Crohn’s disease! 🩸 Blood is commonly used in biomarker discovery and drug development, but how well does it reflect what's actually happening in the gut? 👀 🧵 1/10 🔗 www.medrxiv.org/content/10.1...
🚨 SUPER EXCITED to share our new preprint on the mucosal and circulatory immune landscape of Crohn’s disease! 🩸 Blood is commonly used in biomarker discovery and drug development, but how well does it reflect what's actually happening in the gut? 👀 🧵 1/10 🔗 www.medrxiv.org/content/10.1...
Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn's disease
Crohn's disease (CD) is a heterogeneous disease characterized by chronic inflammation of the gastrointestinal tract driven by an aberrant immune response. To understand the immune mechanisms underlyin...
medrxiv.org
Heading to #EMDS24 in 🇦🇹 this week? Come hear about our work on the "inflammatory handbrake" exerted by intestinal monocytes in human IBD and murine colitis through ACOD1. Wednesday, Session 4 1640-55; See you there! www.biorxiv.org/content/10.1...
