Surface immune signaling unlocks NLR activation through mRNA alternative splicing www.science.org/doi/10.1126/...

Surface immune signaling unlocks NLR activation through mRNA alternative splicing

Plants activate pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) to combat pathogens. However, how these systems coordinate immune activation while preventing autoimmunity remain...

science.org

Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade 🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇

bioRxiv Plant Bio@biorxiv-plants.bsky.social · 3mo ago

A conserved structural logic underlies sensor-helper NLR communication in the NRC immune receptor network https://www.biorxiv.org/content/10.64898/2026.05.18.725810v1

Check out our updated activation-and-release model. This one image condenses over 10 years of work from many legendary @kamounlab.bsky.social members 🤯 Big shoutout to Chih-Hang, @tolgaboz.bsky.social, Lida, Aki, Selvaraj, @jmadhuprakash.bsky.social, @hsuanpai.bsky.social, Ben and many more!

Congrats!, nice paper!. It would be interesting to know how transient are the resistosomes regulating ion transfer during real infection and check their putative autonomous and non-autonomous signaling roles as sensing molecular engines to coordinate defense responses :)

For the textbooks 🤩. Many congratulations to the authors!

Tolga Bozkurt@tolgaboz.bsky.social · 3mo ago

Final version of our NRG1 MS is out! We uncover a surprising mechanism: the helper NLR NRG1 targets organellar membranes to trigger immunity Great collaborations with @KamounLab, @JiorgosKourelis, @jonathandgjones, @AdamWu9527, and the @Phil_Carella labs! science.org/doi/10.1126/sc…

Imperial scientists led by @tolgaboz.bsky.social have uncovered a hidden plant defence system using internal calcium signals. The discovery could help create more resilient crops, reduce pesticide use, and support sustainable food systems. www.imperial.ac.uk/news/article...

Scientists uncover hidden plant defence system that could inform next-generation resilient crops and production

A newly discovered immune mechanism shows how plants use internal calcium signals to fight disease, potentially opening new pathways for stronger, mo...

imperial.ac.uk

A helper NLR channels organellar calcium to trigger plant immunity www.science.org/doi/10.1126/...

A helper NLR channels organellar calcium to trigger plant immunity

Upon activation, plant nucleotide-binding leucine-rich repeat (NLR) immune receptors are known to assemble into oligomeric resistosomes that insert into the plasma membrane, forming calcium (Ca2+)–per...

science.org

Delighted to see this work out in #ScienceAdvancesResearch @science.org where we uncover a surprising evolutionary origin of fungal effector proteins as ancient antimicrobials. Led by the super-star @mesny.bsky.social in the frame of @ceplas.bsky.social @mibinet.bsky.social & @madfungi.bsky.social

Universität zu Köln@unicologne.bsky.social · 3mo ago

🍂🌱 An international research team led by @teamthomma.bsky.social has discovered the surprising evolutionary origin of fungal effector proteins: molecules that pathogens use today to infect their hosts appear to have evolved from ancient antimicrobial proteins. More: ➡️ uni.koeln/UCMWQ #UniCologne

Very excited to see our recent work on NRG1 organellar targeting now published! It has been a pleasure working with Tarhan on this, combining synthetic biology/genetics with some incredible microscopy 🤝 www.science.org/doi/10.1126/...

A helper NLR channels organellar calcium to trigger plant immunity

Upon activation, plant nucleotide-binding leucine-rich repeat (NLR) immune receptors are known to assemble into oligomeric resistosomes that insert into the plasma membrane, forming calcium (Ca2+)–per...

science.org

Final version of our NRG1 MS is out! We uncover a surprising mechanism: the helper NLR NRG1 targets organellar membranes to trigger immunity Great collaborations with @KamounLab, @JiorgosKourelis, @jonathandgjones, @AdamWu9527, and the @Phil_Carella labs! science.org/doi/10.1126/sc…

Just published: A helper NLR challenges the membrane localisation dogma "Plant NLR immune receptors are astonishingly diverse - functionally and structurally. We have only scratched the surface, and there are many more surprises in store." medium.com/p/a-helper-n...

A helper NLR challenges the membrane localisation dogma

PUBLISHED: 30.04.26 | THE SAINSBURY LABORATORY

medium.com

Thrilled to introduce our next act 🎭 in @cp-molcell.bsky.social sciencedirect.com/science/arti... led by @glangin.bsky.social We uncover how proteotoxic stress is integrated across compartments, controlling proteasome activation ⚖️ vs photosynthesis repression 🌱 🧵(1/6) #proteostasis

🚨 Paper out now in #ScienceAdvances @science.org 🌱🦠 Pathogens don’t just target protein degradation—they also hijack host translation. "Bacteria use P-body condensates to attenuate host translation during infection" ⚖️♻️ led by @manuelgonzalezfuen.bsky.social www.science.org/doi/10.1126/...

Proud to share this preprint from Freddie_King and Juan Carlos @AdamWu9527 & @lderevnina labs! AS109-mediated agroinfiltration enables transient expression across non-model plants and positions faba bean as a tractable system for studying disease-resistance

Juan （胡安）@angiopteris.bsky.social · 4mo ago

Finally out! A follow-up to our Rhizobium rhizogenes story with @tolgaboz.bsky.social and Lida. We hope this work will make it easier to study many other plant species. www.biorxiv.org/content/10.6...

Finally out! A follow-up to our Rhizobium rhizogenes story with @tolgaboz.bsky.social and Lida. We hope this work will make it easier to study many other plant species. www.biorxiv.org/content/10.6...

I'm excited to see this out after hearing Matt give a nice seminar a few months ago. Ralstonia is such an interesting pathogen! www.pnas.org/doi/10.1073/...

The EPS-I exopolysaccharide transforms Ralstonia wilt pathogen biofilms into viscoelastic fluids for rapid dissemination in planta | PNAS

Ralstonia solanacearum species complex (RSSC) pathogens cause destructive plant wilt diseases of a wide variety of crops, leading to significant ag...

pnas.org

Exciting PhD positions on plant immunity and engineering plant disease resistance with an excellent supervisor @jiorgoskourelis.bsky.social. Strongly recommend.👇

Jiorgos Kourelis@jiorgoskourelis.bsky.social · 7mo ago

📢 2 PhD Positions Available in Plant Immune Receptor Bioengineering at Imperial College London 🌱 Start: Oct 2026 📅 Deadline: 10 Feb 2026 🇬🇧 UK/settled status only 💰 Fully funded (48 months) ℹ️ Info: shorturl.at/po61I #PlantImmunity #PlantPathology #SyntheticBiology 🙏 Share with interested candidates!

Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses (Enoch Lok Him Yuen, Zachary Savage, Vojtěch Pražák, et al) doi.org/10.1093/plce... #PlantScience

Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses

Chloroplast tethering to the pathogen interface via membrane contact sites promotes focal callose deposition and strengthens plant immunity.

doi.org

Recent paper from @tolgaboz.bsky.social’s group at @imperiallifesci.bsky.social focuses on membrane contact sites between chloroplasts and the pathogen interface and their role in immunity 🎉 Delighted to have helped 🔬

The Plant Cell@theplantcell.bsky.social · 10mo ago

Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses (Enoch Lok Him Yuen, Zachary Savage, Vojtěch Pražák, et al) doi.org/10.1093/plce... #PlantScience

Let's keep in touch: How membrane contact sites drive immune responses url: academic.oup.com/plcell/artic...

Let's keep in touch: How membrane contact sites drive immune responses

Inside every cell, a pulsating network of molecular messengers orchestrates life's most critical conversations. While vesicular trafficking facilitates lon

academic.oup.com

Huge congratulations to Nick Eilmann, our undergrad intern and tutee, for winning two BSPP awards — the Undergraduate Exam Award 2025 and the Undergraduate Project Prize 2025!

Just planted in @jcellsci.bsky.social 🌳 😍 An A. thaliana mutant lacking all nine #ATG8 isoforms provides genetic evidence for functional specialization of #ATG8 in plants forest.biologists.com/landscape/?i...

Landscape - The Forest of Biologists

forest.biologists.com

Congratulations to all involved 🎉 Delighted to have helped a bit with some FLIM-FRET, and amazed at how much chloroplasts do.

Tolga Bozkurt@tolgaboz.bsky.social · 11mo ago

Our latest work on how chloroplasts contribute to immunity: Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses url: academic.oup.com/plcell/artic...

'I feel privileged to do science every day – it is wonderful to be able to follow a passion and be paid for it! It is flexible and absorbing. I would recommend it to everyone.' In Profile: Caroline Dean 📖 nph.onlinelibrary.wiley.com/doi/10.1111/... #LatestIssue #PlantScience

Our latest work on how chloroplasts contribute to immunity: Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses url: academic.oup.com/plcell/artic...

Many thanks to Dr. Dmitry Lapin for writing a highlight of our collaborative study and sharing it on his lab’s website. Learn more about coordinated Ca²⁺ influx cascades for quantitative control of plant immunity here: phoenix-plant.com/highlights-o...

News in plant immunology

Contents Coordinated Ca2+ influx cascades for quantitative control of plant immunity Coordinated Ca2+ influx cascades for quantitative control of plant immunity Written by Dmitry Lapin, J…

phoenix-plant.com

Big cheers to Edward on his last day with us . Thanks for being an awesome BSPP summer intern — we’ll miss having you around! #BSPP #PlantScience

Loved Naomi Nakayama’s talk-truly original research! #PlantBio2025

A mesmerizing time-lapse of the Sun in ultraviolet light, captured by the Solar Dynamics Observatory spacecraft over a month. -Credits: NASA

🦠🧍‍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...