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Trapp Lab

@trapp-lab.bsky.social

A team of researchers at UCL dedicated to understanding the gut-brain axis and its importance for the physiology and treatment of obesity and comorbidities

10 Posts318 Follower132 Folgt
Trapp Lab@trapp-lab.bsky.social · 5mo ago

Our latest work published in Molecular Metabolism www.sciencedirect.com/science/arti... a great team effort with @wanqingjiang.bsky.social, @ceciliaskoug.bsky.social, @drdanbrierley.bsky.social, @ccmnlondon.bsky.social, @uclnpp.bsky.social, @mkbholt.bsky.social and our collaborators at Cambridge.

Brainstem GLP-1 neurons modulate physiological satiation and drive sustained weight loss in obese mice

Glucagon-like peptide-1 receptor (GLP-1R) activation in the brain strongly reduces appetite, but most brain GLP-1Rs are not accessible for systemicall…

sciencedirect.com

Trapp Lab@trapp-lab.bsky.social · 8mo ago

We would like to share our findings of the physiological importance of brainstem GLP-1 neurons (also known as PPG or GCG neurons) and invite thoughts on this. www.biorxiv.org/content/10.6...

Brainstem GLP-1 neurons modulate physiological satiation and drive sustained weight loss in obese mice

Glucagon-like peptide-1 receptor (GLP-1R) activation in the brain strongly reduces appetite, but most brain GLP-1Rs are not accessible for systemically administered GLP-1R agonists. Acute activation o...

biorxiv.org

Trapp Lab@trapp-lab.bsky.social · 12mo ago

Interested in brain access for Tirzepatide-based drugs? Have a look at the fluorescent Tirzepatide analogue developed by Johannes Broichhagen and David Hodson @daveyboyhod.bsky.social‬ out now in Nature Metabolism www.nature.com/articles/s42.... Proud to contribute to this great multi-lab effort.

Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain - Nature Metabolism

A series of fluorescent probes is designed that act as dual agonists on both GLP1 and GIP receptors, and are used to image receptor binding activities in tissues and animals.

nature.com

Trapp Lab@trapp-lab.bsky.social · last yr.

We are recruiting! If you are interested in working as a post-doctoral Research Fellow in the heart of London contributing to MRC-funded research into GLP-1 action within the brain, please look at this link and apply if interested: www.ucl.ac.uk/work-at-ucl/...

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk