Really excited to share our new bioRxiv preprint! 🎉 www.biorxiv.org/content/10.6... In this study, we dissect the roles of GIPR neurons in two adjacent brainstem nuclei, the area postrema (AP) and nucleus tractus solitarius (NTS), and show that they have opposing effects on feeding.

Opposing GIPR brainstem circuits differentially control feeding behaviour

Central glucose-dependent insulinotropic polypeptide receptor (GIPR) signalling is required for the efficacy of GIP-based obesity therapeutics, yet how distinct subpopulations of GIPR neurons shape ap...

biorxiv.org

We're excited to announce that we're recruiting for new academic posts in #AI for #Biodiversity Science, Future #Food Systems & #Health, #NeuroAI, Computational #Neuroscience, and #Cardiovascular/Metabolic Neuroscience. 📅 Apply by 10 July 2026. www.ucl.ac.uk/life-science...

📣 Join us for the next CCMN Lecture as we welcome Dr. Frank Duca for an insightful talk on: 🧠 Impact of the diet-gut microbiome interactions on gut-brain axis regulation of metabolic disease 📅 Monday 15th June ⏰ 1:00 PM 📍 G01 Lankester Lecture Theatre, Medawar Building, UCL

Some new fun read about brainstem PPG neurons and their function. 🧠Happy to be part of this, with main work of @wanqingjiang.bsky.social

Trapp Lab@trapp-lab.bsky.social · 5mo ago

Our latest work published in Molecular Metabolism www.sciencedirect.com/science/arti... a great team effort with @wanqingjiang.bsky.social, @ceciliaskoug.bsky.social, @drdanbrierley.bsky.social, @ccmnlondon.bsky.social, @uclnpp.bsky.social, @mkbholt.bsky.social and our collaborators at Cambridge.

Postdoc job alert! Come work with me on my MRC-funded fellowship on stress and appetite 🧠🌭 at @warwicklifesci.bsky.social 5 years of behaviour, circuit manipulations, neuroanatomy, electrophysiology and transcriptomics👨‍🔬🤓 Oh and Warwick is beautiful😍 Info here: tinyurl.com/yzmf24r3 Please share.

We would like to share our findings of the physiological importance of brainstem GLP-1 neurons (also known as PPG or GCG neurons) and invite thoughts on this. www.biorxiv.org/content/10.6...

Brainstem GLP-1 neurons modulate physiological satiation and drive sustained weight loss in obese mice

Glucagon-like peptide-1 receptor (GLP-1R) activation in the brain strongly reduces appetite, but most brain GLP-1Rs are not accessible for systemically administered GLP-1R agonists. Acute activation o...

biorxiv.org

Happy Holiday Season to all friends, colleagues, collaborators and competitors! May the GLP-1 field stay as exciting in 2026 as it was in 2025!

Our latest thoughts on brain-derived GLP-1 are out in Endocrinology now. academic.oup.com/endo/article...

Brain-Derived GLP-1—Understanding the Physiological Function and Anti-obesity Potential of Preproglucagon Neurons

Abstract. Glucagon-like peptide-1 (GLP-1) is produced within the central nervous system (CNS) by preproglucagon (PPG) neurons. This brain-derived GLP-1, ra

academic.oup.com

New semester, new project students and another opportunity to experience research through a couple pair of enthusiastic eyes! @trapp-lab.bsky.social @ccmnlondon.bsky.social

Dr Cecilia Skoug presenting the latest mouse behaviour data from the Trapp lab at @theiups.bsky.social. Great presence from @ccmnlondon.bsky.social at a fantastic meeting!

Another day, another excellent talk from a @ccmnlondon.bsky.social member. Dr. Anna Robert’s from @adriaenssenslab.bsky.social lab presented her work on GIP and vascular health here at @theiups.bsky.social 2025 meeting in Frankfurt.

More @ccmnlondon.bsky.social representation at #IUPS2025; Philippa Wittenberg, PhD student in Prof. Alex Gourine’s group presented her work on the baroreceptor mechanism.

Last conference for the year for me is IUPS 2025. Yesterday was the well-attended symposium ”GLP-1 Receptor Agonists - a Magic Bullet Beyond Diabetes and Obesity?” Chaired by Prof. Stefan Trapp @trapp-lab.bsky.social Maybe I’m biased but a great symposium indeed! @ccmnlondon.bsky.social

Can targeting GLP-1 in the brain revolutionise obesity treatment? 🧠💉 Check out Professor Stefan Trapp’s take on how central GLP-1 pathways could transform the future of obesity care. www.drugtargetreview.com/article/1606...

Targeting GLP-1 in the brain could transform obesity care

Explore the role of GLP-1 in regulating hunger and appetite, uncovering its complex mechanisms in the brain and gut.

drugtargetreview.com

We are recruiting! If you are interested in working as a post-doctoral Research Fellow in the heart of London contributing to MRC-funded research into GLP-1 action within the brain, please look at this link and apply if interested: www.ucl.ac.uk/work-at-ucl/...

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk

CCMN is off to an amazing start this year. Here are some highlights you don’t want to miss ✨

Swedes would say ”den som väntar på något gott, väntar aldrig för länge”. Thanks to Mathew Demmings for taking the lead and all co-authors. Huge thanks to @isn-society.bsky.social @jneurochem.bsky.social for the oppurtunity and for the advanced school 2019! onlinelibrary.wiley.com/doi/10.1111/...

(Re)building the nervous system: A review of neuron–glia interactions from development to disease

Neuron–glia interactions play a vital role in brain development, influencing processes like neuronal differentiation, synapse development, and myelination. In the mature brain, glial cells maintain h...

onlinelibrary.wiley.com

Fantastic departmental seminar by @zknight.bsky.social, followed by craft beer and bowling for xmas party with the @ccmnlondon.bsky.social crew. Definitely a Good Science Day.

📣 We are excited to launch this year’s CCMN Lecture Series with Dr. @zknight.bsky.social! Join us to learn about his latest work on: In vivo imaging of brainstem neurons in response to nutrient intake. 🗓️ Wednesday, Dec 4, 2024 🕐 13:00 📍 H O Schild Lecture Theatre, Medical Sciences Building

Leaving X (2009-2024) for Bluesky! All new accounts should start with a cute picture of a cat. But will mainly be here for the science chat.