Apply for our Paris Miniscope Workshop this summer: July 1-3, 2026. Come learn to record and analyze calcium imaging data with open source Miniscopes! Applications due this Friday May 22. Apply here: docs.google.com/forms/d/e/1F...

2026 Paris Miniscope Workshop Application

We're excited to invite applications for the 2026 Paris Miniscope Workshop, hosted at ESPCI Paris and organized by Daniel Aharoni (UCLA), Denise Cai and Tristan Shuman (Icahn School of Medicine Mount ...

docs.google.com

Reunion with past and present Cai lab & Shuman lab members (and collaborators). Spending time with you guys is easily the best part of my job. @tristanshuman.bsky.social @sinaibrain.bsky.social @sfn.org

If you are at SFN this week come to our SFN dance party! Monday night at Parq nightclub. Open to everyone. @denisejcai.bsky.social, Kay Tye, and I are giving out VIP bracelets at SFN all weekend!

See you on the dance floor! @tristanshuman.bsky.social

Excited to share that I landed my dream job!🎉🎉🎉 The Pennington Lab will be opening at the University of British Columbia in January 2026! @ubcpsych.bsky.social @dmcbrainhealth.bsky.social

We're looking forward to the first annual New York Memory Hub conference later this week! Can't wait for all the talks and discussion about all things learning and memory 🧠

🚨New preprint alert🚨 We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)

Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.

Zoé Christenson Wick@zoechristensonwick.bsky.social · 11mo ago

🚨New preprint alert🚨 We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)

Check out our latest paper today in Nature: “Goal specific hippocampal inhibition gates learning” www.nature.com/articles/s41... By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.

🚨 New lab paper!🚨 A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇 www.nature.com/articles/s41...

Human neural dynamics of real-world and imagined navigation - Nature Human Behaviour

Seeber et al. studied brain recordings from implanted electrodes in freely moving humans. Neural dynamics encoded actual and imagined routes similarly, demonstrating parallels between navigational, im...

nature.com

Grid cells have a geometry in time. Thanks to @azvollan.bsky.social l & @rjgardner.bsky.social for this heroic discovery. @ercresearch.bsky.social #KiloNeurons @m-bmoser.bsky.social @kavlintnu.bsky.social @nature.com @kavlifoundation.bsky.social www.nature.com/articles/s41...

Left–right-alternating theta sweeps in entorhinal–hippocampal maps of space - Nature

A study in rats proposes a mechanism for how the brain maps the surrounding environment, including places it has never seen, by alternating left and right forward sweeps in successive theta cycles.

nature.com

New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment. www.cell.com/cell-reports...

My boss has been in DC a lot longer than I have - and deep inside. He has taught me a lot about how DC works. (I hope I've taught him some things about academia.). Here's what he posted on LinkedIn with our News story.

Interested in how neural communication breaks down in a model of Alzheimer's pathology? In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided with the onset of spatial memory deficits in 3xTg mice. (1/6) www.biorxiv.org/content/10.1...

New preprint from the lab! @laurenmvetere.bsky.social found disrupted MEC-hippocampal synchronization that paralleled the emergence of memory deficits in the 3xTg mouse model of AD pathology! Check it out and let us know what you think.

Lauren Vetere@laurenmvetere.bsky.social · 2y ago

Interested in how neural communication breaks down in a model of Alzheimer's pathology? In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided with the onset of spatial memory deficits in 3xTg mice. (1/6) www.biorxiv.org/content/10.1...

Did 2024 feel LONG to anyone else? A little 2024 recap from me: I defended my PhD and submitted a first author paper describing my thesis work! Look out for a preprint very soon. (1/6)

Hey #ACNP2024!!! I’ve been inspired by y’all to start a new thread to capture the amazing #FashionsOfACNP! Please add on🙏🏼💃🏻🕺 First up: the one and only @jaredwyoung.bsky.social! The shoes. The kilt. The vest. Perfection 🧑‍🍳😘

Thank you to NIH Director Dr. Bertagnolli for sharing our recent work in her latest blog post! I’m so proud of the team and first author @joezaki.bsky.social for all their hard work on these exciting new findings examining stress & memory-linking 🧠 Read here 👇 directorsblog.nih.gov/2024/12/05/s...

Study Suggests New Experiences Can Refresh Memories of Past Events, with Implications for Understanding PTSD

Your memories of life experiences are encoded in collections of neurons in the brain that were active at the time the event took place. Later, those same patterns of neural activity are replayed in…

directorsblog.nih.gov

SO EXCITED to share our latest work demonstrating that the anterior hypothalamic nucleus (AHN) regulates stress vulnerability!!!

Denise J. Cai, Ph.D.@denisejcai.bsky.social · 2y ago

❓ Do you know what the anterior hypothalamic nucleus (AHN) does? No? Neither did we! 🧠 In a new preprint from the Cai Lab, learn how we discovered the AHN’s central role in regulating stress vulnerability. Read the paper here: www.biorxiv.org/content/10.1... (1/6)

This is going to be a great conference! Excited to join!

Tomás Ryan@tjryan.bsky.social · 2y ago

Registration & Abstract Submission is open for the 2025 "Engram and Ensembles in Learning and Memory" meeting, at Trinity College Dublin in May. Abstract deadline February 14. #EngramsandEnsembles2025 Preliminary Agenda at event website: event.fourwaves.com/engramsensem...

A thread on NIH Reorganization and the Scientific Management Review Board (SMRB) Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through. 1/n

🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10) Read it here: www.nature.com/articles/s41...

xcited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture. www.sciencedirect.com/science/arti...

Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice

Stress induces aversive memory overgeneralization, a hallmark of many psychiatric disorders. Memories are encoded by a sparse ensemble of neurons acti…

sciencedirect.com

Come work with us at Mount Sinai! We have an open search for tenure-track faculty in the Department of Neuroscience focusing on Computational and Systems Neuroscience. Feel free to reach out to me with questions. neuroscience.mssm.edu/docs/Faculty... Initial review will begin next week!

go.bsky.app/LdtUYZS I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent. Tell me who I haven’t found yet

Open faculty search at Mount Sinai in Computational and/or Systems Neuroscience. Deadline is November 15th, 2024 neuroscience.mssm.edu/pdf/faculty-...

NEW PREPRINT! Led by recent PhD Susie Feng, we characterized memory impairment and entorhinal-hippocampal desynchronization in epileptic mice. We found early hippocampal deficits and late-onset MEC deficits that emerged with progressively worse cognitive impairment. www.biorxiv.org/content/10.1...

Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org