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Alice Wicks

@ubch-alice.bsky.social

Postdoc researching ubiquitin biology @fletcherlab.bsky.social @CVR in the context of viral infection. Equality, Diversity, and Inclusion (EDI) Advocate. What I say here is my personal opinion. X: UbcH_Alice thefletcherlab.co.uk

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Clausen Lab@clausenlab.bsky.social · last wk.

could not be prouder of lillie and the fantastic story she uncovered - from a giant E3 ligase with an unexpected dimer switch to moyamoya mutations that hijack its regulation. a beautiful PhD project, full of surprises and scientific creativity doi.org/10.64898/202... - bsky.app/profile/lill...

doi.org

Lillie Bell@lilliebell.bsky.social · last wk.

Happy to share my PhD work on the regulatory mechanism of E3 ligase RNF213! RNF213 is not a monomer, but a dimer that switches between inhibited and activated states in an ATP-dependent manner. We tracked the activation mechanism and showed how disease mutations can destabilize the inhibited state.

Fletcher Lab@fletcherlab.bsky.social · 5mo ago

Delighted to share our article on the functional expansion of OAS2 via alt. splicing. link.springer.com/article/10.1... A tour de force from PhD student Emma Davies and friends.

Alternative splicing broadens antiviral diversity at the human OAS2 locus - The EMBO Journal

Interferons (IFN) are cytokines that regulate the expression of hundreds of genes during viral infections to generate a broadly antiviral environment in the stimulated cell. Antiviral breadth is provi...

link.springer.com

Cell Chemical Biology@cp-cellchembiol.bsky.social · 7mo ago

Online now! Online now! Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins #chembiol

Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins

In this study, Gustafsen et al. introduce SORTACs, a PROTAC-like strategy that hijacks the sortilin-progranulin pathway to drive lysosomal degradation of extracellular proteins. SORTACs enable modular, small molecule and biologic degraders, expanding targeted protein degradation beyond the cytosol to previously inaccessible extracellular targets.

dlvr.it

Fletcher Lab@fletcherlab.bsky.social · 7mo ago

Receptor clustering is a common theme in viral detection, but whether detection directly hinders genome replication is less clear. Excited to share the Z in RZ-type E3s: ZNFX1 is an RNA helicase that builds ubiquitin chains leading to aggregates that ensnare viral RNA. www.cell.com/molecular-ce...

ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA

Squair et al. show that ZNFX1 restricts ssRNA virus replication by integrating SF1 helicase activity with dual E3 ligase mechanisms. ATP-dependent RNA binding activates E3 function, driving self-propa...

cell.com

Cell - a Cell Press journal@cp-cell.bsky.social · 7mo ago

Now online! The E3-ome gene-centric compendium reveals the human E3 ligase landscape

The E3-ome gene-centric compendium reveals the human E3 ligase landscape

The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented knowledge, this framework provides a foundation for studying ubiquitin signaling and accelerating discovery.

dlvr.it

Alice Wicks@ubch-alice.bsky.social · 9mo ago

My first-author paper is out in @chemicalscience.rsc.org from my time in Professor Danny Huang’s laboratory @cruk-si.bsky.social. We showed that CBL can be used as a degrader E3 to target the “undruggable” eIF4E. pubs.rsc.org/en/content/a...

CBL ubiquitin ligase targets translation as a degrader E3

Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules that recruit an ubiquitin ligase (E3) and a neo-substrate into a ternary complex, enabling selective protein degradation. Desp...

pubs.rsc.org