Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion | 🤩

FTFY

Richard Sever@richardsever.bsky.social · 4w ago

Better with Kane surely…

Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.

I wanted to like QED's new 1% preprint ranking. I really did. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review. open.substack.com/pub/blekhman...

My Peer Review of The 1%

I wanted to like QED's new 1% ranking. I don't.

open.substack.com

For the first time, we can see individual mRNAs in 3D inside cells at nm precision. Their shapes vary by gene and subcellular location. Congrats @fbzt.bsky.social & team @impvienna.bsky.social Top 1% @qedscience.bsky.social Edited by @lifescienceeditors.bsky.social www.biorxiv.org/content/10.6...

Super-resolved imaging of mRNA ultrastructure in cells

Messenger RNA (mRNA) is a central polymer of gene expression, whose ultrastructure and defining regulatory rules remain unclear. To visualize the ultrastructure of mRNA, we here develop Combi-PAINT, a...

biorxiv.org

Congratulations to Gautam Dey (EMBL) and Omaya Dudin (University of Geneva) for being awarded the EMBO Gold Medal 2026 in recognition of their outstanding contributions to the #LifeSciences in Europe! 🧪 https://www.embo.org/press-releases/embo-gold-medal-2026-awarded-to-gautam-dey-and-omaya-dudin/

New study published in Science! Led by @thevirusmc.bsky.social and @plantophagy.bsky.social, former group leader at the GMI of the @oeaw.bsky.social, the researchers set out to understand how autophagy – the cell’s clean-up and recycling system – mediates plant immune response to viral infection.

"I would like to emphasize the importance of question-driven science...young scientists might enjoy science more if they are thinking about questions rather than just collecting data" journals.biologists.com/jcs/article/...

Interview with Noboru Mizushima – President of the Japan Society for Cell Biology

Noboru Mizushima is Professor of Biochemistry and Molecular Biology at the University of Tokyo, Japan, where he runs a laboratory studying the mechanisms and physiological functions of autophagy and o...

journals.biologists.com

Open Postdoc Position - Giant E3 ligases: mysterious mechanisms & non‑protein substrates. Interested? Join us to uncover how these molecular giants tag lipids, RNAs, sugars beyond proteins, on organelles and pathogens, to defend the cell. Details & Application here www.imp.ac.at/career/open-...

😀 see also www.nature.com/articles/s41...

RNA-triggered cell killing with CRISPR–Cas12a2 - Nature

Cas12a2 enables RNA-triggered, sequence-specific killing of eukaryotic cells via widespread DNA shredding, allowing selective elimination of cells on the basis of gene expression, including virus-infe...

nature.com

Doudna Lab@doudna-lab.bsky.social · 3mo ago

New pre-print 📣 “Undruggable” cancer mutations remain very hard to target with current modalities. What if we could instead sense mutant transcripts and convert that recognition into selective cell killing? Check out this work led by postdoc Jingkun Zeng: www.biorxiv.org/content/10.6...

Our paper is finally out! 🥳 If you want to know how a single Salmonella effector rewires the whole macrophage transcriptional landscape by hijacking one host transcription factor, check our latest research! Thanks to the @thurstonlab.bsky.social and @peterwshill.bsky.social labs for an amazing work!

Salmonella effector SteE reprograms the macrophage regulatory network to drive specific hyperactivation of STAT3 target genes

The ability of Salmonella Typhimurium to exploit macrophages as a niche for survival, replication, and dissemination is central to its pathogenesis. T…

sciencedirect.com

We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!

Structure-function analysis of the bacterial ClpE/ClpP AAA+ protease - Journal of Biological Chemistry www.jbc.org/article/S002...

Structure-function analysis of the bacterial ClpE/ClpP AAA+ protease

General and regulatory proteolysis in bacteria is executed by a set of ATP-dependent proteases composed of hexameric ring-forming AAA+ proteins and associated peptidase barrels (e.g. ClpP). These AAA+...

jbc.org

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...

Cryo-EM structure of yeast telomerase

YouTube video by MRC Laboratory of Molecular Biology

youtube.com

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 4mo ago

Led by Investigator Scientist @hongmiaohu.bsky.social, @kellythd-nguyen.bsky.social’s group in the LMB’s Structural Studies Division have produced the first ever structure of telomerase from yeast. Read more here: mrclmb.ac.uk/news-events/... #LMBResearch #cryoEM 🧪

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

We’re looking for a creative & enthusiastic postdoc with expertise in cryo-EM or protein biochemistry to join @annebertolotti.bsky.social (LMB Neurobiology Division) and help solve structures of key stress signalling enzymes and develop new inhibitors. www.nature.com/naturecareer... Apply by 22 MAR

The Trojan Horse is real, and it’s microscopic! 🐴🦠 Our paper is out today in @cellcellpress.bsky.social! We discovered that deltaviruses physically hide INSIDE helper viruses to sneak into new cells. And to prove it, we had to image them from every angle. 🧵👇 www.sciencedirect.com/science/arti...

Deltaviruses spread through a viral Trojan Horse

Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

sciencedirect.com

Ubiquitin & Friends Fiesta in Vienna, 29-30 April 2026. Great speakers, small size, a friendly community, perfect for early-career researchers to connect with fellow ubiquitin enthusiasts. Sign up at www.protein-degradation.org/symposium/ and submit abstracts for talks and awards. #ubfriends26

You are passionate about ubiquitin, proteostasis and cellular biochemistry and want to be part of a collaborative, ambitious, excited and fun team? I am recruiting PhD students via the @imprs-lm.bsky.social graduate school: www.imprs-lm.mpg.de/index.php/le... (2/3)

I am incredibly excited to share that I will start my independent lab at the @unidue-zmb.bsky.social at the @unidue.bsky.social as Junior Professor of Cellular Biochemistry. Research in my lab has the goal to decipher the ubiquitin code! There are multiple open positions! (1/3)

🚨⚠️ New Preprint Alert! ⚠️ 🚨 www.biorxiv.org/content/10.6... Screening p97 cofactors, @prithadg.bsky.social identified FAF2 as the strongest activator of the p97-UFD1-NPL4 complex. Leveraging her mechanistic descoveries, we designed 𝘥𝘦 𝘯𝘰𝘷𝘰 binders that could also enhance p97 substrate unfolding.

seems interesting www.biorxiv.org/content/10.6...

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA www.science.org/doi/10.1126/... co-first with: @andschwarz.bsky.social with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more 🧵 0/6 #MolBio 🧪

Polymerization-inducing chimeras (PINCHs) are a novel bifunctional modality that sequesters target homodimers in a polymeric state, thereby inhibiting their function www.nature.com/articles/s41...

A pharmacological modality to sequester homomeric proteins - Nature Chemical Biology

Polymerization-inducing chimeras are a novel bifunctional modality that uses protein symmetry to sequester targets by forming insoluble supramolecular assemblies. This approach overcomes reliance on a...

nature.com

Happy to share our newest preprint on Parkin missense variants in work led by Erna Sol & @vvouts.bsky.social in @rhp-lab.bsky.social Using a multiplexed assay we determined the effects of 9,212 out of 9,300 single amino acid substitutions and nonsense Parkin variants. 1/n doi.org/10.64898/202...

bioRxiv Genetics@biorxiv-genetic.bsky.social · 6mo ago

Comprehensive Variant Effect Map of Parkin-Mediated Mitophagy in Parkinson's Disease https://www.biorxiv.org/content/10.64898/2026.02.09.704749v1

And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story: www.nature.com/articles/s41...

IMP@impvienna.bsky.social · 6mo ago

To regulate gene activity, proteasomes - waste disposal machines of cells - must enter the nucleus. IMP Researchers now show how the adaptor protein AKIRIN2 helps ferry this massive complex through the nuclear pore: https://www.nature.com/articles/s41467-026-69162-0

Look at this 🙂 #CryoEM Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org www.biorxiv.org/content/10.6...

Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @Yale www.nature.com/articles/s41...

On the balance of knowledge - Nature Reviews Immunology

Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

nature.com

A new paper reports a “nucleotide code” that coordinates Lis1-dynein binding stoichiometry, which in turn governs Lis1’s ability to relieve dynein autoinhibition www.nature.com/articles/s41...

A nucleotide code governs Lis1’s ability to relieve dynein autoinhibition - Nature Chemical Biology

A combination of biochemical, cell biological and electron microscopy analyses reveal a ‘nucleotide code’ that coordinates Lis1–dynein binding stoichiometry, which in turn governs Lis1’s ability to re...

nature.com

I’m excited to share my first-author paper, with co-first author @rongqinxiaoxiao.bsky.social, now out in @nature.com. We developed a live-cell single-particle tracking platform to see how TRiC & prefoldin engage proteins during co- and post-translational folding. 1/9 www.nature.com/articles/s41...

Single-molecule dynamics of the TRiC chaperonin system in vivo - Nature

Single-particle tracking experiments in intact cells reveal dynamic co- and post-translational interactions of the TRiC–PFD chaperonin complex with client proteins during in vivo protein folding.

nature.com