CPMDS Research Highlight 🔬 Computational models reveal how the autonomic nervous system regulates blood flow and blood pressure across molecular, cellular, and tissue scales, providing insights that could guide future precision cardiovascular therapies.

Smooth signals: computational insights into autonomic vascular control | American Journal of Physiology-Cell Physiology | American Physiological Society

The regulation of vascular tone underlies normal cardiovascular homeostasis, ensuring appropriate distribution of blood flow to tissues and maintenance of blood pressure. Computational modeling and si...

journals.physiology.org

New publication in Nucleic Acids Research describing CATVariant, an open-access web server for integrated protein variant interpretation. 🔗 Read the paper: doi.org/10.1093/nar/... 🌐 Try CATVariant: catvariant.com #Bioinformatics #PrecisionMedicine #Genomics #ProteinVariants #NAR #OpenScience

CATVariant: a web server for integrated protein variant interpretation across sequence, structure, population, and clinical evidence

Abstract. Efficient interpretation of the structural, functional, and clinical impact of protein variants remains a longstanding challenge. This difficulty

doi.org

@ucdcpmds.bsky.social · 2mo ago

CPMDS Research Highlight 🔬 CATVariant is a new open-access webserver for studying genetic variants, integrating population, clinical, structural, and literature data with computational predictors to help interpret variant effects. Read more: doi.org/10.1093/nar/... | Explore: catvariant.com

CPMDS Research Highlight 🔬 CATVariant is a new open-access webserver for studying genetic variants, integrating population, clinical, structural, and literature data with computational predictors to help interpret variant effects. Read more: doi.org/10.1093/nar/... | Explore: catvariant.com

CPMDS Research Highlight 🔬 (Drs. Igor Vorobyov, Vladimir Yarov Yarovoy, Colleen E. Clancy) Researchers used advanced simulations to reveal how ligands dissociate from membrane receptors, uncovering hidden molecular pathways that could improve drug discovery and precision therapeutics. 💻

🔬 CPMDS Research Highlight (Dr. Pei-Chi Yang) New eLife research introduces AI-powered “digital twins” of heart cells, using synthetic data and electrophysiology to predict cell-specific behavior. This work could advance precision medicine, drug safety testing, and arrhythmia research.

New research shows how AlphaFold can predict hERG ion channel states, improving drug safety screening and helping identify arrhythmia risks earlier in drug development. A major step toward safer, AI-driven therapeutics. #AI #DrugDiscovery Read more here: pmc.ncbi.nlm.nih.gov/articles/PMC...

Harnessing AlphaFold to reveal hERG channel conformational state secrets

To design safe, selective, and effective new therapies, there must be a deep understanding of the structure and function of the drug target. One of the most difficult problems to solve has been the re...

pmc.ncbi.nlm.nih.gov

🔬 CPMDS Research Highlight New research highlights how AI and digital health technologies are improving healthcare quality and patient safety through proactive, data-driven care, clinical decision support, telehealth, and better care coordination. #DigitalHealth pubmed.ncbi.nlm.nih.gov/40752934/

Health Care Quality and Patient Safety in the Era of Artificial Intelligence - PubMed

The integration of digital health technologies is revolutionizing health care quality and patient safety by shifting from reactive to proactive care models. Advances in electronic health records, clin...

pubmed.ncbi.nlm.nih.gov

🔬CPMDS Research Spotlight New research highlights how advances in cardiovascular ion channel and Ca²⁺ signaling research are shaping future therapies for heart disease, including arrhythmias and heart failure. ❤️🫀 Read more: pubmed.ncbi.nlm.nih.gov/41605640/

Congratulations to @vorobyovucd.bsky.social and @laiherwh.bsky.social, winners of this quarter’s School of Medicine Research Image Competition! Image description: Dark blue representation of space and constellations. Photo of Lai holding a paper award and gift basket. Photo of Igor in gray suit.

🔬 CPMDS Research Spotlight (Dr. Emilie Roncali): CFD is advancing cancer therapy by modeling blood flow & drug transport to improve targeting and reduce side effects. Integrating with imaging & AI could enable more personalized treatment. lnkd.in/deHn6Pp4 #CancerResearch #PrecisionMedicine

Associate Director for Computational Biomedicine Dr. Emilie Roncali recently gave a keynote on theranostics digital twins and in silico models at the Virtual Imaging Trials in Medicine workshop 2026!!

Congrats to Frederick Ha who presented his research at the Undergraduate Research, Scholarship and Creative Activities Conference at UC Davis! Image Description: Frederick stands at the front of a classroom giving a presentation.

CPDMS Research Spotlight (Dr. Deborah Lieu): New research in Stem Cell Reports reveals insights into how cellular programs regulate stem cell behavior, deepening our understanding of development and advancing potential applications in tissue repair and disease modeling www.cell.com/stem-cell-re...

A humanized engineered heart tissue platform for cardiotoxicity assessment

In this article, Sun and colleagues develop a humanized engineered heart tissue platform by integrating human ventricular extracellular matrix with GCaMP6f-expressing hiPSC-derived cardiomyocytes. Thi...

cell.com

In this new #Review, Chiara Anna Giordani (@ucdcpmds.bsky.social) and @clancyatheart.bsky.social discuss #dose as a fundamental organizing principle in physiology. 💉 💊 🔗 Read it here: www.sciencedirect.com/science/arti...

Congratulations to Dr. Fred Meyers on receiving the 2026 ACTS Distinguished Educator: Mentorship Innovation Award! This honor recognizes innovative mentorship advancing translational science and supporting diverse researchers. Proud to celebrate this achievement! 🎉

New research shows common therapies, estrogen, metformin, statins, and vitamin D, may unintentionally affect regulatory T cells (Tregs), key to immune balance. Understanding these effects could help advance more precise, personalized care. pubmed.ncbi.nlm.nih.gov/41855744/

Deep Learning Echocardiographic Trajectories of Heart Failure With Preserved Ejection Fraction: A Retrospective Cohort Study - PubMed

Longitudinal phenomapping resulted in echocardiographic trajectories of cardiac structure and function with different clinical, laboratory, and survival characteristics. HFpEF is a dynamic condition, ...

pubmed.ncbi.nlm.nih.gov

🔬 Ionizing radiation reshapes heart cell function—not just tissue damage. Low–moderate doses: pro-arrhythmic High doses: improved electrical stability 🧠 Mitochondria drive these effects 💡 May help optimize radiotherapy & reduce cardiac risk 📖 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Cellular mechanisms of radiation‐induced myocyte dysfunction: effects on calcium handling, ion channel regulation and mitochondrial energetics

Abstract figure legend Dose-dependent effects of radiation on cardiac electrophysiology and arrhythmia susceptibility. At low radiation doses (left), increased reactive oxygen species (ROS) initiate ....

physoc.onlinelibrary.wiley.com

Jan 14, 2026: The Data Science Seminar Series spotlighted theranostics & digital twins in cancer care. Emilie Roncali shared advances in liver, prostate & metastatic cancers improving diagnosis, treatment & outcomes. www.cancer.gov/about-nci/or... #CancerResearch #DigitalTwin #PrecisionMedicine

Theranostics and Digital Twins for Personalized Medicine

On January 14, the Data Science Seminar Series is tackling an intersection of two critical data science concepts in cancer research: theranostics and digital twins. By combining computational and clin...

cancer.gov

Congrats to Vladimir Yarov-Yarovoy on the GenScript Life Science Research Grant for his AI-driven drug discovery work! His research on ion channels could help treat arrhythmias and neuropathic pain. Selected from 500+ applications, an outstanding achievement!

A team including Colleen Clancy published a primer on using digital twins in biomedical research—bridging AI, mechanistic models, and real data to create virtual representations of living systems. This approach can deepen our understanding of biology and improve future healthcare.

Digital Twins as New Approach Methodologies (NAMs) in Biophotonics Led by Moderator Dr. Colleen Clancy this panel explores how digital twins are transforming healthcare from AI-driven care to treatment optimization and device simulation shaping the future of medicine. spie.org/photonics-we...

SPIE Photonics West Special Event Digital Twins as New Approach Methodologies (NAMs) in Biophotonics

spie.org

AI is uncovering hidden states of human Naᵥ channels ⚡️ AlphaFold2 predicts multiple conformations + key interactions (β-subunits, calmodulin), opening new paths for drug discovery. Experimental validation next—but the potential is huge. rupress.org/jgp/article-...

Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Lopez-Mateos et al.’s study demonstrates AlphaFold2’s potential to sample multiple states of human NaV channels. Additionally, NaV α-subunit interactions w

rupress.org

Dr. Vladimir Yarov Yarovoy attended the 2nd World Sodium Channel Conference in Grindelwald, Switzerland, and presented a recently published research project entitled “Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2”

Diego Lopez Mateos, postdoctoral researcher at the Center for Precision Medicine and Data Science at UC Davis, presented both a platform talk and a poster at the 2026 Biophysical Society Annual Meeting at San Francisco in the "Ion Channel Regulation, Pharmacology and Disease"

Khoa Ngo presented a talk on the development of an open-access, interactive web server that helps researchers interpret genetic variants by analyzing their potential impact on protein structure and function.

What if HFpEF isn’t just a cardiac disease? We mined 38M+ PubMed abstracts with ML. 5,124 proteins identified. Strong overlap with metabolic comorbidities. Top signals? Liver & adipose tissue — not the heart. HFpEF may be a multi-organ systemic disorder. #HFpEF #Cardiology #AI

Thermal medicine, the controlled use of heat and cold has been part of healing traditions for millennia. Now, thanks to new sensors, wearables, and AI, researchers can track individual thermal responses with unprecedented precision and turn them into personalized health insights.

This new review highlights how digital health tools from AI‑powered decision support to telehealth and advanced data analytics are shifting care from reactive to proactive, boosting clinical decisions and care coordination. Check out this paper: pubmed.ncbi.nlm.nih.gov/40752934/

Health Care Quality and Patient Safety in the Era of Artificial Intelligence - PubMed

The integration of digital health technologies is revolutionizing health care quality and patient safety by shifting from reactive to proactive care models. Advances in electronic health records, clinical decision support systems, data analytics, artificial intelligence (AI), mobile applications, an …

pubmed.ncbi.nlm.nih.gov

December 2025 - At the Member Forum, the Physiological Society’s Editors-in-Chief including Director Colleen Clancy took the stage for an In Conversation session to share insights on research, publishing, and advancing the field together. #Physiology #ScientificPublishing #ResearchCommunity

October 2025 - Director Colleen Clancy shared groundbreaking work on using digital twin technology to transform cardiovascular medicine. By combining computational modeling, AI, and multimodal biomedical data, her team is building personalized virtual replicas of the human heart.