Fascinating study on Aβ-oligondendrocyte interaction in AD and how it potentially contributes to myelin loss using human forebrain organoids! By Merck & Co. Inc www.biorxiv.org/content/10.6...

Plaque-associated oligodendrocyte proteostatic failure underlies myelin loss in Alzheimer’s disease

Alzheimer’s disease (AD) features amyloid-β plaques and tau pathology, yet the mechanism underlying early and clinically significant myelin loss remains unresolved. Here, we report human iPSC-derived ...

biorxiv.org

Meet our 4th Social Media Ambassador! Welcome Shirsha Nandi, an Erasmus+ trainee in the Moyon Lab (Marseille). Her research explores how rejuvenating aged #oligodendrocytes could promote CNS repair. As a Network Glia Ambassador, she will showcase glia research and support early-career researchers.

Research Fellow role at UCL developing Alzheimer’s prognostic models using machine learning, imaging, fluid biomarkers and clinical data. Closing date: 12th August www.dementiaresearcher.nihr.ac.uk/job/research...

Research Fellow: Neuroimaging - DEMENTIA RESEARCHER

UCL seeks a Research Fellow to develop Alzheimer’s prognostic models using machine learning, imaging, fluid biomarkers and clinical data.

dementiaresearcher.nihr.ac.uk

📣 REGISTRATION IS OPEN 📣 Our 7th annual #BlackInNeuroWeek is coming soon 🧠 From July 27th to August 2nd, we have an ✨AMAZING✨ week of events planned for you all, free and open to the public 🤗 Don’t miss out! Register for #BINW26 here ⤵️ events.zoom.us/ev/AgaErvpe_... #BlackInSTEM #Neuroskyence 🧪

“Women are tired of confronting a medical system that was never designed to serve them. They want basic answers about their bodies ... Matrescence is such a beautiful time, and for scientists to be able to approach it with awe and curiosity is just such a special thing.”

How Pregnancy and Motherhood Reshape the Human Brain

Neuroimaging and animal research reveal how pregnancy hormones remodel neural circuits and leave a long-lasting mark on women’s bodies and health.

the-scientist.com

Transcriptomic signatures associated with mania-to-depression and depression-to-mania transitions in bipolar disorder: a case report using induced microglia-like (iMG) cells https://www.biorxiv.org/content/10.64898/2026.07.12.735946v1

Plaque-associated oligodendrocyte proteostatic failure underlies myelin loss in Alzheimers disease https://www.biorxiv.org/content/10.64898/2026.07.08.737318v1

Excited to share that one of the very first research projects initiated in our ABCD lab, "Astrocytic Ankyrin-2 Enables Memory Persistence in the Mouse Hippocampus," has now been published in Nature Communications (DOI: 10.1038/s41467-026-75009-5). www.drkohlab.com/post/our-art...

Astrocytic Ankyrin-2 Enables Memory Persistence in the Mouse Hippocampus

Why do some memories last for weeks, months, or even years, while others quickly fade away? Astrocytes may hold the key.

drkohlab.com

In our latest pre-print, we show that mice with the neuropathy-causing GARS1 ∆ETAQ mutation display robust pathology in subsets of peripheral nerves: www.biorxiv.org/content/10.6... Well done @beccasimkin.bsky.social and Aurélie Paulo-Ramos! @uclqsneuromuscular.bsky.social @uclqsion.bsky.social

Excited to share this work, led by Andrew Zimnik and Sherry An, from @mchurchland.bsky.social and my labs! www.cell.com/neuron/fullt... 1/2

Sparse component analysis: A method that uncovers separable computations within neural population activity

Zimnik et al. provide a new, interpretable, unsupervised dimensionality approach for neural population activity. Their approach, sparse component analysis (SCA), reveals the latent factors correspondi...

cell.com

❗Honored to be cited in Science Advances 👏Prof. Yan Li’ team reveals the neural circuit mechanisms underlying the co-occurrence of social deficits and attention deficits in autism. Brain_VTA offers AAV packaging services. www.science.org/doi/10.1126/...

Parallel anterior cingulate cortex pathways underlie dissociable social and attentional outputs

Activating two distinct circuits in the anterior cingulate cortex separately restored social and attention deficits in ASD mice.

science.org

#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

Grape Seed Proanthocyanidin Extract (GSPE) Mitigates Preterm White Matter Injury in Mice Via Improving Mitochondrial Homeostasis and Activity of IMMP2L-Related Signaling Pathway

brain-regeneration.com

12 childhood cancers. 12 workshops. 24 months. We've just hosted the final Paediatric Therapeutic Development Workshop – a major milestone towards new treatment options for childhood cancers with the greatest unmet need. Read more: https://t.ly/SO81e

Meet Abrar AbuHamdia, PhD candidate at HBKU blending brain organoid models with systematic reviews to push dementia science forward. www.dementiaresearcher.nihr.ac.uk/profile-abra...

Profile – Abrar AbuHamdia, Hamad Bin Khalifa University - DEMENTIA RESEARCHER

Abrar AbuHamdia is a PhD candidate developing brain organoid models and reviewing treatments and surgery for neurological disorders.

dementiaresearcher.nihr.ac.uk

Topline results from the Phase 2 LiBBY trial suggest a THC/CBD combination rapidly and significantly reduces agitation in hospice-eligible people with dementia. #AAIC26 #DementiaResearch Read more: www.dementiaresearcher.nihr.ac.uk/libby-trial-...

LiBBY Trial: THC/CBD Reduces End-of-Life Agitation - DEMENTIA RESEARCHER

Phase 2 LiBBY trial results suggest a THC/CBD combination rapidly and significantly reduces agitation in hospice-eligible people with dementia. #AAIC26

dementiaresearcher.nihr.ac.uk

FENSGlia may be over, but there's plenty more ahead! The international #glia community keeps growing, with exciting meetings across Europe in the coming months—from the 1st Polish Glia Meeting to the European Glial Meeting 2027 in Bologna. Find them all here: https://www.networkglia.eu/calendar/

I'm looking forward to #FENS2026 Don't miss the #hypoxia session on Friday morning, fantastic line up of speakers #neuroscience #astrocytes #pericytes

Article “in press” @natcomms.nature.com! We show that MCT2 regulates oligo metabolism to promote maintenance of myelin and axonal integrity. @uv.es @biologiques-uv.bsky.social @achucarro.bsky.social @cipfvalencia.bsky.social @institutducerveau.bsky.social @univpoitiers.bsky.social 🧵👇

❗News︱Cell Metabolism 👏Prof. Xiangdong Gao’s Team develops an oral GLP-1R agonist for the treatment of Alzheimer's disease. 👇MORE www.sciencedirect.com/science/arti...

Oral GLP-1 receptor agonist promotes astrocyte-neuron lactate and lipid transfer with neuroprotective effects

Glucagon-like peptide-1 receptor (GLP-1R) activation is widely assumed to regulate the metabolic disorder in Alzheimer’s disease (AD). However, direct…

sciencedirect.com

Spotlight Silva et al. show that #microglial cathepsin B is essential for clearing dying neurons during #BrainDevelopment. Loss of cathepsin B disrupts efferocytosis, impairs neural circuit formation, and alters behaviour in zebrafish and mice. https://www.nature.com/articles/s41467-026-70350-1

Microglial cathepsin B is necessary for neuronal efferocytosis in zebrafish and mice during brain development - Nature Communications

Microglia, the brain’s immune cells, are important for neuronal phagocytosis during brain development. Here the authors show that microglial lysosomal protease cathepsin B is required for efficient neuronal efferocytosis during brain development.

nature.com

Fascinating times.. each week we learn more and more about the LC www.nature.com/articles/s41...

A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms - Molecular Psychiatry

Molecular Psychiatry - A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms

nature.com

Research Spotlight Sasmita et al. show that #oligodendrocytes are a source of amyloid-β in #Alzheimers disease. Blocking Aβ production in oligodendrocytes reduced plaque burden by ~30%, highlighting #glia as drivers of pathology and therapeutic targets. https://pubmed.ncbi.nlm.nih.gov/39103558/

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice - PubMed

Amyloid-β (Aβ) is thought to be neuronally derived in Alzheimer's disease (AD). However, transcripts of amyloid precursor protein (APP) and amyloidogenic enzymes are equally abundant in oligodendrocytes (OLs). By cell-type-specific deletion of Bace1 in a humanized knock-in AD model, APP^NLGF …

pubmed.ncbi.nlm.nih.gov

Focal astrocyte Kir4.1 loss drives seizures, spreading depolarizations and postictal impairments https://www.biorxiv.org/content/10.64898/2026.06.15.732359v1

UCL is hiring for 5 new positions! Individual job details below!👇 #ScienceJobs

Hi, everyone! We have been working hard to improve the #BrainRegeneration site for you. This time we have a new search page: brain-regeneration.com/search/?utm_... It should help you find the best research, and your feedback is always appreciated! #neurology #multipleSclerosis // @brunoamaral.eu

Advanced Search

Search research papers and clinical trials across all conditions and research areas tracked by the Brain Regeneration Observatory.

brain-regeneration.com

❗News︱Exploration 👏Prof. Ru Zhang’s Team reports a novel mechanism driving microglial abnormalities and the pathological progression of Alzheimer's disease. 👇MORE onlinelibrary.wiley.com/doi/10.1002/...

RBFOX1 Dysfunction Unlocks APOE4‐Associated Microglial Genesis and Exacerbates Alzheimer's Pathology in Human Cerebral Organoids

Genomic studies implicate RBFOX1 in Alzheimer's disease (AD) risk, highlighting the need to define its role and interactions with other risk factors. Here, CRISPR/Cas9-mediated RBFOX1 loss in APOE4 h...

onlinelibrary.wiley.com

NPAS3-regulated #astrocyte #mitochondrial #bioenergetics is required for #cognition | Science Advances www.science.org/doi/10.1126/...

NPAS3-regulated astrocyte mitochondrial bioenergetics is required for cognition

NPAS3 regulates astrocyte energy metabolism required for cognition, highlighting glial targets for neuropsychiatric disorders.

science.org

Our new paper on a rapid, reliable way to make induced astrocytes for co-culture with neurons is out on bioRxiv: www.biorxiv.org/content/10.6... We hope this system will be a useful tool for illuminating the pathways underlying neuron-astrocyte interactions. More to be shared soon!

iAstrocytes model cytokine influences on complement expression and neuronal network synchronization.

Astrocytes play essential roles in neuronal development, function, and disease, yet existing methods to derive astrocytes from human pluripotent stem cells (hPSCs) are complex and can involve months o...

biorxiv.org

The lysosomal cation channel TRPML1 regulates the oligodendrocyte cytoskeleton https://www.biorxiv.org/content/10.64898/2026.06.16.731945v1

Research Assistant role at the University of Oxford supporting the SHINE study on early Alzheimer’s disease using cognitive, EEG, MEG and MRI assessments. Closing date: 3rd July www.dementiaresearcher.nihr.ac.uk/job/research...

Research Assistant: Cognitive Neuroscience

University of Oxford seeks a Research Assistant to support the SHINE study on early Alzheimer’s using cognitive, EEG, MEG and MRI assessments.

dementiaresearcher.nihr.ac.uk