Vacancy alert! We are recruiting a Research Laboratory Technician to join the Genome Stability and DNA Repair Lab. 📍Bailrigg, Lancaster 💷 £26,707–£30,378 📅 Closing date: 9 August 2026 🔎 Reference: 0607-26 Further details and applications: hr-jobs.lancs.ac.uk/Vacancy.aspx...

Job Opportunity at Lancaster University: Research Laboratory Technician

We are looking for a Research Technician to support our research studies exploring how a ubiquitin ligase contributes to DNA replication stress and repair. The position is funded by an Academy of Medi...

hr-jobs.lancs.ac.uk

We're looking for volunteers for a citizen science project that's helping to deliver aid in Venezuela 🌍 The Planetary Response Network uses crowd-sourced data to identify damage to buildings, access difficulties, and signs of people in distress by reviewing satellite images.

Appeal for citizen scientists after Venezuela earthquakes - Lancaster University

Scientists from Lancaster University are appealing for volunteers to help a citizen science project helping the delivery of humanitarian aid in the wake of two earthquakes within less than one minute of each other in Venezuela.

pulse.ly

We’re excited to have a fully funded PhD available starting in October >> Please direct any excellent MSc/MRes students interested in innate immunity, molecular biology and initiation of cancer to our project: www.findaphd.com/phds/project... @unterholznerlab.bsky.social @blslancasteruni.bsky.social

Investigating chronic inflammation caused by asbestos-like fibres as a driver of mesothelioma at Lancaster University on FindAPhD.com

PhD Project - Investigating chronic inflammation caused by asbestos-like fibres as a driver of mesothelioma at Lancaster University, listed on FindAPhD.com

findaphd.com

Very proud of Otto, his PhD work and his viva performance- a privilege to supervise with @unterholznerlab.bsky.social 🎉

Unterholzner Lab@unterholznerlab.bsky.social · 3mo ago

Proud PIs, with @lucyhjackson-j.bsky.social. Well done Otto for completing your PhD viva! Another PhD flying the nest from @blslancasteruni.bsky.social. Thanks to the examiners @fieldinglab.bsky.social and Pierre Maillard!

Proud PIs, with @lucyhjackson-j.bsky.social. Well done Otto for completing your PhD viva! Another PhD flying the nest from @blslancasteruni.bsky.social. Thanks to the examiners @fieldinglab.bsky.social and Pierre Maillard!

Our LUMICKS C-Trap Dynamo 300 is now installed and running, funded by BBSRC ALERT 2024. Huge thanks to Tomas Soolsma at LUMICKS for three great days of training. 🧪🔬

I have a 3-year postdoc position available at University of Manchester for a mass spec expert in proteomics. The person will be involved in exciting projects in single cell proteomics, drug discovery and innate immunity - on timsTOF Ultra AIP & HF & Astral Zoom. www.jobs.ac.uk/job/DQJ093/r...

Both MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate). Listen, I get that UKRI wants to pivot. But killing both at once is devastating. Let's hope at least one opens by summer... #AcademicSky

MRC instructs grant review boards to slash funding rates - Research Professional News

Boards asked to recommend just three applications for funding, as BBSRC also suspends calls

researchprofessionalnews.com

I have zero problem with UKRI loooking at and evolving their funding strategy. This doesn't explain why a cull of live applications AND 12 month pause to other new funding is necessary to bring the new strategy in... 🤷‍♂️

Open letter from Ian Chapman to research and innovation community

UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.

ukri.org

Excited to announce a new review article that Andreas Villunger @villungerlab.bsky.social, Dario Rizzotto (not on bsky) and I wrote. In this article, we discuss mitosis as a central cell cycle stage for integrating DNA damage, cell death and inflammatory responses. www.nature.com/articles/s41...

Mitotic errors as triggers of cell death and inflammation - Nature Cell Biology

Rizzotto et al. discuss the causes and consequences of deregulated mitosis that allow cells arrested in mitosis to escape to the next interphase, where they can initiate inflammatory signalling or und...

nature.com

2026 is here! We’re excited to share Global Immunotalks first semester poster, featuring an outstanding lineup! Please share and help us spread the word!

Come and work with us! We're looking for a talented postdoc with interests in developmental biology, cancer and the primary cilia to join us @mortlab.bsky.social. An exciting MRC funded collaboration with Pleasantine Mill - @cilialab.bsky.social. Further details: www.jobs.ac.uk/job/DPR804/s...

Senior Research Associate at Lancaster University

Apply for the Senior Research Associate role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.

jobs.ac.uk

Online Now: IFI16 senses and protects stalled replication forks Online now:

IFI16 senses and protects stalled replication forks

Gamble et al. demonstrate that detection of stalled replication forks by the innate immune sensor IFI16 induces an early STING-dependent pro-inflammatory cytokine response independently of cGAS and DNA damage. Furthermore, IFI16 exhibits dual functionality during replication stress by protecting stalled, remodeled replication forks from nucleolytic degradation.

dlvr.it

Excited to see this out in Molecular @cellpress.bsky.social - Congratulations @unterholznerlab.bsky.social @stapleslab.bsky.social 🎉

Unterholzner Lab@unterholznerlab.bsky.social · 7mo ago

We've got a new paper out! In collaboration with @stapleslab.bsky.social @cejkalab.bsky.social @lucyhjackson-j.bsky.social, we show that IFI16 binds to stalled replication forks, protects nascent DNA and mediates an inflammatory response to replication stress. authors.elsevier.com/sd/article/S...

New paper in collaboration with @unterholznerlab.bsky.social @cejkalab.bsky.social IFI16 protects stalled replication forks. www.sciencedirect.com/science/arti...

IFI16 senses and protects stalled replication forks

Replication stress is a key driver of DNA damage and genome instability. Here, we report that replication stress induces an inflammatory response in t…

sciencedirect.com

We've got a new paper out! In collaboration with @stapleslab.bsky.social @cejkalab.bsky.social @lucyhjackson-j.bsky.social, we show that IFI16 binds to stalled replication forks, protects nascent DNA and mediates an inflammatory response to replication stress. authors.elsevier.com/sd/article/S...

Congratulations to BLS Lecturer Dr Amy Saunders who has co-authored research featured on the front cover of this week's issue of #ScienceSignaling! Dr Saunders' research has updated our understanding of how glycans help immune cells move into skin in psoriasis. www.science.org/doi/10.1126/...

Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation

Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.

science.org

Congratulations to Prof Alona Armstrong of Lancaster Environment Centre for being named on The ENDS Report's Power List 2025, which spotlights the environmental professionals who have made the greatest impact in the past two years 🌍💡 @alona-armstrong.bsky.social | @endsreport.com

Power List 2025: The academics shaping the science on environmental issues

ENDS Report's Power List spotlights the environmental professionals who have made the greatest impact in the past two years. Here, we meet those working in science, research and development who are co...

endsreport.com

Closing on soon - you have until the 14th to apply for our interdisciplinary PhD studentship - develop new cell-based infection models & AI analysis to study infections and discover antimicrobials. Link below.

Gunnar N. Schroeder@gunnarns.bsky.social · last yr.

Funded 4-year #PhD in the exciting BBSRC NILAB program. @wwiem-qub.bsky.social Receive multidisciplinary training, develop #infection models and #AI image analysis to reveal bacterial & viral disease mechanisms & discover new antimicrobials. Fight #AMR Get in touch! Details: tinyurl.com/e5k6ptua

New online: Transcription stress causes an inflammatory response via release of IL-1α

Transcription stress causes an inflammatory response via release of IL-1α

Nature Structural & Molecular Biology, Published online: 11 April 2025; doi:10.1038/s41594-025-01525-5DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can also initiate inflammation by causing the direct release of cytokine IL-1α, which then drives NF-κB activation in neighboring cells.

go.nature.com

We have written a News&Views piece in @natsmb.nature.com on a recent paper by @buissonlab.bsky.social. Their work adds transcription stress to the landscape of danger signals detected by the innate immune system. Link for free access here: rdcu.be/ehkTV

Transcription stress causes an inflammatory response via release of IL-1α

Nature Structural & Molecular Biology - DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can...

rdcu.be

Rémi Buisson@buissonlab.bsky.social · 2y ago

Today @naturesmb.bsky.social 🥳, we report that the activation of NF-κB after DNA damage can occur through two distinct mechanisms. While ATM triggers NF-κB activation after DSBs, we found that IRAK1 specifically induces NF-κB in response to DNA damage causing transcriptional stress.

Today @naturesmb.bsky.social 🥳, we report that the activation of NF-κB after DNA damage can occur through two distinct mechanisms. While ATM triggers NF-κB activation after DSBs, we found that IRAK1 specifically induces NF-κB in response to DNA damage causing transcriptional stress.

ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage - Nature Structural & Molecular Biology

In this study, the authors show that DNA-damage-mediated transcriptional stress induces NF-κB through IRAK1, allowing damaged cells with impaired transcription to initiate an inflammatory response wit...

nature.com

Pre-print alert! Together with @stapleslab.bsky.social and @cejkalab.bsky.social we find that IFI16 binds to stalled replication forks where it acts as innate immune sensor for replication stress, and protects the nascent DNA from degradation. 👇👇

@stapleslab.bsky.social · last yr.

New preprint from the lab, revealing new roles for IFI16 during replication stress. Great collab with @unterholznerlab.bsky.social and @cejkalab.bsky.social www.biorxiv.org/content/10.1...