I know nobody likes a Bsky rant, but here goes. There's a recent stream of manuscripts I'm reviewing that seem to randomly refer to figure panels. It makes it so difficult to follow a paper. One constantly thinks, did I miss something? What do all the intervening panels show? Please do not do this!

Nice write-up of my postdoc mentor Hiro Funabiki's work. "Happy families are all alike, but every unhappy family is unhappy in its own way. [...] When chromosome division works correctly, it always works the same way. But there are so many ways it can go wrong." tinyurl.com/ry9rkk4c

Are you looking for a postdoc exploring the cell biology of development, defining how cells change shape and move? Do you want to develop a research program & teaching skills preparing you for a position at a college or small University? Our new NIH grant will support those goals 1/n Please share

As highly recommended as possible! Alex and her lab are brilliant. Plus, you would be our neighbour! 😀

Alex Radzisheuskaya@a-radzisheuskaya.bsky.social · last mo.

We’re hiring! 🧬 We're looking for a Postdoctoral Training Fellow to join our group at the ICR in London and work on chromatin biology, transcription regulation and AML. Curious about how histone modifications shape gene regulation and cell identity? Come join us! jobs.icr.ac.uk/vacancies/15...

Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 www.nature.com/articles/s41... (1/2)

Our highlights of the @embo.org workshop Pathogen Immunity & Signaling 2026 just came out in @natimmunol.nature.com! www.nature.com/articles/s41...

New frontiers in pathogen immunity - Nature Immunology

The EMBO workshop ‘Pathogen Immunity and Signaling’ was held from 8 to 11 June 2026 in Leiden, the Netherlands, bringing together 175 participants from 25 countries to discuss the latest advances in a...

nature.com

Supremely excited to share our new paper in @natcellbio.nature.com With an updated genetic cGAMP reporter, we reveal that cGAS activation by DNA damage is a rare event, and that cGAS enrichment on intracellular structures cannot be taken as evidence of activation. www.nature.com/articles/s41...

A versatile cGAMP reporter reveals principles of cGAS activation by DNA damage and chromosome instability - Nature Cell Biology

Lebrec et al. present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chroma...

nature.com

(1/6) 🔥🔥 Double hot for two new papers by our PhD graduate Adriana Loverre! 1️⃣ A dendritic cell autophagy-neutrophil axis limits intratumoral STING immunotherapy 📖 Science Immunology We uncover an unexpected mechanism limiting the efficacy of intratumoral STING therapy. 🧵👇

Fantastic story from our fantastic neighbour @a-radzisheuskaya.bsky.social ! Site-directed mutagenesis of individual sites in all histone clusters!

Alex Radzisheuskaya@a-radzisheuskaya.bsky.social · 4mo ago

1/ Very excited to share the first publication from my lab! In this work, we developed an efficient strategy to precisely mutate mammalian histone genes in their native genomic context using CRISPR prime editing: www.nature.com/articles/s41...

I'd planned not to write about politics here but some things are too infuriating. Wes Streeting, who has lots of Mandelson connections, and -18% disapproval, plans an early power bid, just to prevent the only candidate with positive approval, Andy Burnham (+10%), from competing tinyurl.com/3j7jx2s7

Wes Streeting plans to resign and mount leadership challenge, allies say

Sources say health secretary intends to trigger leadership election as early as Thursday

theguardian.com

If you are interested in PARP inhibitors and history, this might be of interest to you. www.nature.com/articles/s41.... An attempt to cover the work of thousands and their immense contributions to the development of a targeted approach to treating cancers.

Two decades of PARP inhibitor synthetic lethality in cancer - Nature

The past two decades of PARP inhibitor synthetic lethality in cancer is explored.

nature.com

Another classic from @albertociccia.bsky.social & @angelotaglialatela.bsky.social!

Alberto Ciccia@albertociccia.bsky.social · 6mo ago

Happy to share our new review in @annualreviews.bsky.social on abasic sites and their impact on DNA replication written by @angelotaglialatela.bsky.social. www.annualreviews.org/content/jour...

Excited to share our structural insights into how microtubules differentially guide phosphorylation of kinetochore-microtubule regulators, Ndc80 and MCAK, for chromosome segregation. Heroic efforts by Yiming Niu with a fun collaboration with Jennifer DeLuca lab! www.science.org/doi/10.1126/...

Microtubules guide Aurora B substrate geometries for accurate chromosome segregation

Cryo-EM reveals how kinetochore-microtubule attachment is regulated by Aurora B substrate accessibility on microtubules.

science.org

The Rockefeller University @rockefeller.edu · 7mo ago

Microtubules have been viewed as passive structural supports, but a study from @hirofunabiki.bsky.social in @science.org Advances redefines microtubules as active regulators, helping to prevent abnormalities in the number of chromosomes, a hallmark of cancer. 🔗: https://bit.ly/4v8miCC

Microtubules have been viewed as passive structural supports, but a study from @hirofunabiki.bsky.social in @science.org Advances redefines microtubules as active regulators, helping to prevent abnormalities in the number of chromosomes, a hallmark of cancer. 🔗: https://bit.ly/4v8miCC

👋 To all aneuploidy and chromosome instability aficionados check out the Consequences of Aneuploidy FASEB conference (Florida-USA 🏖️) co-organised with @peterlylab.bsky.social, Mike Lampson, Alison Taylor and myself: events.faseb.org/event/Aneupl... 👉 Deadline for abstract submission: August 3rd.

You are interested in immunology and how nucleic acid structures contribute to their function and how this impacts disease development - Rayk Behrendt and myself have open PhD positions for a joint PhD program between Bonn and Osaka.

To kickstart this new Bluesky account: We're hiring! The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab. Details in the flyer — get in touch! 👇

NOW LIVE!: PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis. www.sussex.ac.uk/study/fees-f...

NealeLab@labneale.bsky.social · 9mo ago

Coming soon! PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social Keep a look out and get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.

Delighted to share our new paper on LXR agonism pre-conditioning T cells to more readily adopt effector states, out in @jem.org today. This was a long project started in @sohailtavazoie.bsky.social's lab and completed across the atlantic here in Berlin at Charité.

Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity

Ostendorf et al. show that activation of liver-X-receptors preconditions T cells to render them more receptive to adopting effector states upon activation.

doi.org

If you're a physics researcher, please sign this letter. Anyone in the biomedical sciences know of a similar letter for our fields? Or anyone interested in putting one together? ecr-openletter-stfc.github.io#sign-form

Physics are hit worst, but it's not just physics. @ukri.org, it's not too late to reverse course. www.theguardian.com/science/2026...

UK ‘could lose generation of scientists’ with cuts to projects and research facilities

UK’s research funding body says best scientists are taking posts overseas due to lack of job stability at home

theguardian.com

2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word. crick.ac.uk/WayPostdoc20...

As I predicted, the cutting of @ukri.org funding is to provide "more emphasis on commercialisation". This is an absolutely terrible decision. Most startups fail, or are bought by larger competitors. In both cases, their research is frequently lost from the public domain www.bbc.co.uk/news/article...

UK’s £8bn research fund faces “hard decisions” as it pauses new grants

UKRI boss Ian Chapman said it had been told by the government to

bbc.co.uk

Yes @ukri.org, please provide clarity and reasons for this chain of events. It would be a huge disadvantage to UK innovation if we went down a path of science funding that is similar to Trump's USA.

Adrian Saurin@adesaurin.bsky.social · 9mo ago

@ukri.org Could you please make a statement about whether this will impact on grants already in review from autumn 2025? It's hard to accept grant opportunities closing, but even harder to accept the rug being pulled after review. Rumours of a 1-5% acceptance rate would be incredibly hard to take

This is an absolute outrage that should be discussed as widely as possible. I expect that this failing government will try and use the MRC to divert funding from academic research into commercial enterprises, killing UK research in the process.

Mark A. Hanson@hansonmark.bsky.social · 9mo ago

Both MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate). Listen, I get that UKRI wants to pivot. But killing both at once is devastating. Let's hope at least one opens by summer... #AcademicSky

Excited to announce a new review article that Andreas Villunger @villungerlab.bsky.social, Dario Rizzotto (not on bsky) and I wrote. In this article, we discuss mitosis as a central cell cycle stage for integrating DNA damage, cell death and inflammatory responses. www.nature.com/articles/s41...

Mitotic errors as triggers of cell death and inflammation - Nature Cell Biology

Rizzotto et al. discuss the causes and consequences of deregulated mitosis that allow cells arrested in mitosis to escape to the next interphase, where they can initiate inflammatory signalling or und...

nature.com

Parkes lab pre-print alert! ‘TMEM33 deletion potentiates anti-tumor CD8⁺ T cell immunity.’ Led by mtjackson101.bsky.social. Full bluetutorial follows! 1/10 www.biorxiv.org/content/10.6...

Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study! www.nature.com/articles/s41...

We are pleased to present our manuscript on the annotation of clear cell Renal Cell Carcinoma #GWAS risk loci, recently published in @commsbio.nature.com www.nature.com/articles/s42... #ccRCC #cancer #genetics #genomics #KidneyCancer

The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris). The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at: minilien.curie.fr/3avv47