Wallace Marshall
@wallaceucsf.bsky.social
professor at UCSF, engineer turned cell biologist, wants to know how cells solve geometry problems
Congratulations everyone!
American Society for Cell Biology@ascbiology.bsky.social · 3d agoCongratulations to the 2026 ASCB Honorific Award Winners! ASCB is proud to recognize scientists whose research, mentorship, education & leadership are helping shape the future of cell biology. See all the awardees: https://www.ascb.org/society-news/ascb-announces-2026-honorific-award-winners/
Congratulations to the 2026 ASCB Honorific Award Winners! ASCB is proud to recognize scientists whose research, mentorship, education & leadership are helping shape the future of cell biology. See all the awardees: https://www.ascb.org/society-news/ascb-announces-2026-honorific-award-winners/
Congratulations to the 2026 ASCB Fellows! ASCB is proud to recognize 15 scientists whose careers have advanced cell biology through outstanding research, leadership, mentorship & service. Meet the 2026 Fellows: https://www.ascb.org/society-news/fifteen-visionary-scientists-named-2026-ascb-fellows/
🚨 HEADS UP: If you haven't submitted a comment on the OMB proposal yet, there's still time - but it's running out! There are only 10 days left to push back against Russell Vought's attempt to give political appointees unprecedented control over federal research funding. Take Action: zurl.co/Bl59I
8 hours. That’s all fish need to heal wounds 🐟⏱️ Why are they so fast compared to humans? I break down the science of rapid regeneration in a microscopy story 🔬 Watch here: youtu.be/Mt9f61adaP0 #FluorescenceFriday #Microscopy
I had a ton of fun the other day talking with @nonresidentdesi.bsky.social and @scifri.bsky.social 's Flora Lichtman and Rasha Aridi about murderous microbes and the things that we are trying to learn from them. Happy for the opportunity to bring some new awareness to the world of protists!
Science Friday@scifri.bsky.social · last mo.Researchers like Ben Larson and Glen D’Souza are piecing together the world of killer microbes, including why they turn on each other and if their tiny weapons could be harnessed to fight disease. Listen to the podcast now: www.sciencefriday.com/segments/kil...
Heemskerk, I., & Streichan, S. J. (2015). Tissue cartography: compressing bio-image data by dimensional reduction. Nature methods, 12(12), 1139-1142. #EpithelialMechanics doi.org/10.1038/nmet...
Tissue cartography: compressing bio-image data by dimensional reduction - Nature Methods
Handling and quantitative image analysis of layered tissues is greatly simplified by cartography with the Image Surface Analysis Environment (ImSAnE), as demonstrated on a variety of specimens, includ...
doi.org
Coupled nucleoplasmic flows and envelope expansion govern the mechanical resistance of the nucleus https://www.biorxiv.org/content/10.64898/2026.06.12.731963v1
Happy to announce our new preprint is out, in which we analyze single-cell learning in Stentor in the frequency domain, and find that the cell behaves like a fractional-order low pass filter. www.biorxiv.org/content/10.6...
elizabethginexi.substack.com/p/summary-of... every US scientist needs to submit a comment. the audience is judges down the line, not the OMB itself. refer to specific sections, explain what you think about them especially if the language is unclear or contradictory. you are an expert witness
Summary of Key Changes in OMB’s Proposed Federal Financial Assistance Rule
Russell Vought is going to destroy American Science
elizabethginexi.substack.com
Wow, this isn't just "we're banning you for 1 year," it's "future work can't be posted until it's peer-reviewed", i.e.,you can no longer use the arXiv for preprints.
anil oza@aniloza.bsky.social · 3mo agowow — the preprint host, arxiv, is banning authors for a year if they submit papers with hallucinated citations 🤖
you've heard alot about how cells are or are not crowded at the molecular scale, but what about at the organelle scale? in her new preprint, @marymirvis.bsky.social develops a quantitative way to ask this question in budding yeast - see her thread below www.biorxiv.org/content/10.6...
biorxiv.org
Mary Mirvis@marymirvis.bsky.social · 3mo ago1/13 So excited to share our new preprint!! How do organelles pack together in a crowded cytoplasm? we know organelles interact via contact sites, but how does competition for space contribute to organelle morphology and interactions? @wallaceucsf.bsky.social www.biorxiv.org/content/10.6...
As part of her RNAseq and proteomics analysis of single-celled learning in Stentor, one of the molecules that Deepa Rajan found to be changing during learning and forgetting was an EF-hand protein. I want to tell you why we think this is interesting
My PhD work showed that resting neutrophil -> activated/prime neutrophil is a pretty big volume change needed for motility :) Super fast, only a couple minutes to swell so not like other slower changes elifesciences.org/articles/90551
Neutrophils actively swell to potentiate rapid migration
Actin-independent water influx complements actin-driven cytoskeletal forces to potentiate chemoattractant-induced migration in primary human neutrophils.
elifesciences.org
Basically the last 16 years of my lab‘s research is on the role of cell swelling as an alarm signal…initially dismissed by some as fish-specific response, because -obviously- only what is shown in mouse can be important 🙄
The "Version of Record" of my paper with Mike Woodford is finally there. I am very glad with this paper that points to new laws of psychophysics, which we derived from a carefully considered principle of endogenous efficient coding.
Endogenous precision of the number sense
A theory of efficient coding wherein the precision of representations is endogenous, task-dependent, and prior-dependent predicts scaling laws for imprecision and is supported by numerosity perception...
elifesciences.org
a big surprise in @deeparajan.bsky.social recent paper identifying molecular pathways of single-cell learning in Stentor, was how effective RNA sequencing turned out to be, revealing CamKII and EF hand proteins that were then shown by RNAi to actually play a role. www.cell.com/current-biol...
This exciting paper is now out in PNAS: www.pnas.org/doi/10.1073/...
3D epithelial cell topology tunes signaling range to promote precise patterning | PNAS
Cell behaviors in multicellular organisms are coordinated via both diffusible molecules and by signals based on direct cell–cell contacts. The mode...
pnas.org
Yanlan Mao@yanlanmao.bsky.social · 12mo agoAn exciting new paper from the lab! Check it out:
It’s starting to seem like changes in cell volume are turning up in many different cases of cell state transitions. Would be nice to collect examples.
Journal of Cell Biology@jcb.org · 3mo ago#PressRelease 📰 How #macrophages interpret and respond to immune danger signals remains a mystery. Researchers @manchester.ac.uk have found that increases in cell volume reprogram macrophage gene expression and induce #inflammation. 👉 www.eurekalert.org/news-release...
Cambridge → Boston → Cambridge again: I’m thrilled to return to Cambridge(UK) to open my lab at the Gurdon Institute, University of Cambridge!🥳 (mzhulab.com) We study how dev timing shapes and being shaped by plasticity, evolution & ageing. 🚩Hiring at all levels: pls email me if interested!📩
Meng Zhu Lab
We study how development measures time and how timing matters in development, evolution and ageing.
mzhulab.com
Up close, these tiny organisms in cow stomachs are surprisingly beautiful and evocative. Known as rumen ciliates, these microbes could be playing a more significant role in climate change than previously understood, according to new research. https://wapo.st/422MqS5
Ready for #CellLaVie2026? Program & registration are live! Join us Oct 21–23, 2026 at Institut Pasteur, Paris, for multidisciplinary cell biology, imaging, talks, posters & outreach, w/ Manuel Théry's behind-the-scenes look at the Musée d’Orsay video-mapping project. www.atoutcom.com/cell-la-vie/
If you are interested in how single cells are able to learn, check out this beautiful article by @niko-kukushkin.bsky.social www.sciencedirect.com/science/arti...
Cellular memory: Learning without building
A new study reveals that habituation in the single-celled ciliate Stentor coeruleus uses the same calcium and kinase signaling as animal memory but do…
sciencedirect.com
UW-Madison generated a $13.2 billion economic impact on the state over the last fiscal year. Another $12.4 billion was generated by spinoff companies rooted in UW-Madison research. Vice Chancellor Craig Thompson: "The economic impact...is substantial no matter where you live in the state."
UW-Madison says it generated billions for state's economy last year
A new analysis released by UW-Madison says the university contributed billions in statewide economic impact last fiscal year.
wpr.org
We discovered a new species! Our paper on Stentor stipatus is now published @wallaceucsf.bsky.social @aralbright.bsky.social
We're hiring! 🔬🏔️ Looking for curious, open-minded, and multidisciplinary #PhD candidates to research at the intersection of #mitochondria, #metabolism, #imaging & #physiology, with the #Alps as a backdrop. Sounds like you or someone you know? Link below! @fbm-unil.bsky.social @unil.bsky.social
Juan C. Landoni@jclandoni.bsky.social · 4mo agoThe Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI
Congratulations to Deepa Rajan for this masterpiece! This is the fourth in her series of papers exploring how a single cell can learn without a brain.
Deepa Rajan, PhD@deeparajan.bsky.social · 3mo agoHow can a single cell learn without a brain? We explore this in my paper with @wallaceucsf.bsky.social! We discovered that single cells may learn using molecules similar to those that animal brains use to learn, like CaMKII. Cells can also propagate memory states to their progeny!
How can a single cell learn without a brain? We explore this in my paper with @wallaceucsf.bsky.social! We discovered that single cells may learn using molecules similar to those that animal brains use to learn, like CaMKII. Cells can also propagate memory states to their progeny!
