I'm not sure folks have realized just how crazy the second half of 2026 and 2027 will be for global temperatures – on the back of a record-smashing El Niño event. Here is my latest estimate of where both years will end up compared to global temperatures since 1850.

Watch a muscle fiber take shape. 🔬 This microscopic video captures a muscle cell fusing with a developing muscle fiber, with cell membranes visible in purple and yellow. The Rando Lab uses live-cell imaging to understand how cells coordinate muscle regeneration. Credit: Tamas Nagy/Rando Lab

New Toettchlab paper alert! Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration. www.cell.com/cell-systems...

Interesting work that shows that frontier models are basically not improving in reliability despite them appearing to do better on benchmarks. Reliability is key to trust. Hard to imagine LLMs being trusted with critical operations until this is solved, *if* it can be. arxiv.org/pdf/2602.16666

New paper 🧵 What if the "landscape" that guides cell differentiation isn't fixed, but is sculpted, in real time, by the very cells moving through it? We call this a 'sandscape' : grains of sand that carve dunes as they move, while the dunes' shape simultaneously steers where the grains go next.

Excited to share our new paper, now published in Nature Cell Biology! 🎉 We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces? www.nature.com/articles/s41556-026-01981-1

CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

nature.com

This is clearly top 1% quality data

Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

Got to play around with Holotomographic imaging of muscle cells yesterday via the @uclastemcell.bsky.social imaging core and the results are pretty spectacular 🤩 You can see everything from mitochrondria to lamellipodia to macropinocytosis…with no labels!

It really is concerning how few people know that this is the case.

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

How much of Thermo Fisher’s antibody data has been manipulated?

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

reeserichardson.blog

We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...

📣 The difference between replicable and not replicable is not itself scientifically replicable. 📣 New work with Erkan Buzbas, showing that verdicts such as "X% of results replicated" are based on an inferential machinery that doesn't work. arxiv.org/abs/2604.26268

Trainees jump on this! Juan is an awesome human and he’s gonna do some amazing science ✨ Can’t wait to see what he gets up to!

Juan C. Landoni@jclandoni.bsky.social · 4mo ago

The Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI

What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~ www.biorxiv.org/content/10.6...

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

For me, the most maddening thing is when AI boosters, or detractors, all seem to agree that AlphaFold is an unmitigated good and useful tool showing the power of AI. I disagree. It's hit and miss. And the misses are REALLY expensive. Especially when the conversation suggests it is ALL HIT.

Jake Janey@phlogiston1.bsky.social · 4mo ago

The most maddening quip I hear from the tech overlords is “AI will cure all disease” or some variation thereof. Either they say these things due to their absolute naivety on drug discovery and/or they put out these press release to pump up their valuations.

I don't think people fully appreciate how apocalyptic things are for US science. I haven't had any new funding since 2024, but I'm still ok since typical grants are for three years. This means next year I will be completely out of funding and will have to fire everyone in the lab. It's not great.

Jeremy Berg@jeremymberg.bsky.social · 5mo ago

NSF Update through March 13, 2026 1/2

A high-affinity split-HaloTag for live-cell protein labeling. And much more. www.nature.com/articles/s41...

A high-affinity split-HaloTag for live-cell protein labeling

Nature Communications - Lin and colleagues present high-affinity split-HaloTag pairs for protein tagging and multiplexed labelling. This versatile system allows protein visualisation with diverse...

nature.com

Tamas Nagy@tamasnagy.com · 5mo ago

So excited to be drowning in new "findings". Coming soon to a journal near you! 🫠 github.com/aiming-lab/A...

So excited to be drowning in new "findings". Coming soon to a journal near you! 🫠 github.com/aiming-lab/A...

GitHub - aiming-lab/AutoResearchClaw: Fully autonomous & self-evolving research from idea to paper. Chat an Idea. Get a Paper. 🦞

Fully autonomous & self-evolving research from idea to paper. Chat an Idea. Get a Paper. 🦞 - aiming-lab/AutoResearchClaw

github.com

Federal funding for US biomedical research is moribund. Since October 1 2025, NIH is -80% in new grants and -70% in values (total dollars). Labs are closing down and researchers are leaving science. To what end?

Do folks have a preferred protocol for bleaching fluorescent proteins prior to doing Immunofluorescence? I tried a 3% H2O2 + 12mM HCl solution but I had severe cell detachment problems (despite everything being fixed).

@science.org Evolution of error correction through a need for speed | Science #evolution 🧬🔬 www.science.org/doi/10.1126/...

Evolution of error correction through a need for speed

Kinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication, transcription, and translation. Proofreading is typically assumed to ...

science.org

Absolutely wild timeline we live in TLDR: An agentic AI bot writes a takedown blog post of a matplotlib maintainer after he rejects its pull request. @arstechnica.com screws up and use AI to write a piece about the incident which hallucinates quotes. 🤦 theshamblog.com/an-ai-agent-...

An AI Agent Published a Hit Piece on Me

Summary: An AI agent of unknown ownership autonomously wrote and published a personalized hit piece about me after I rejected its code, attempting to damage my reputation and shame me into acceptin…

theshamblog.com

Interesting study from *Anthropic* that found that AI use didn’t significantly speed up development on a novel task (w/ new Python async lib) but it did hurt understanding. Unsurprisingly, AI seems best at regurgitating common patterns and isn’t that helpful for novel ones. arxiv.org/pdf/2601.20245

Why is it that small animals like insects have a landspace body plan when viewed head-on, but larger animals like elephants are taller than wide? With @m-v.bsky.social, we find out in our new preprint titled 'Size and shape of terrestrial animals' - arxiv.org/html/2602.00...

Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de

For all the talk about accelerating science, tools like this will likely slow things down because we have wade through mountains of AI garbage. The consequences need to grow for faking results.

Raphael Wimmer@raphaelwimmer.bsky.social · 6mo ago

OpenAI just released Prism, a LaTeX editor with embedded ChatGPT for free. Writing a paper has never been easier. Clogging the scientific publishing pipeline has never been easier. It took me 54 seconds to write up an experiment I did not actually conduct. prism.openai.com

Peer review science relies, more than we care to admit, on what @zey.bsky.social calls "load bearing frictions" that make it difficult to fake good science, and on trust that most ppl also value science itself & won't cheat just for personal gain. This creates the wrong environment for that to hold.

Raphael Wimmer@raphaelwimmer.bsky.social · 6mo ago

OpenAI just released Prism, a LaTeX editor with embedded ChatGPT for free. Writing a paper has never been easier. Clogging the scientific publishing pipeline has never been easier. It took me 54 seconds to write up an experiment I did not actually conduct. prism.openai.com