Black yeasts are efficient heterologous hosts for the production of a wide range of fungal polyketides - Nature Chemical Biology

Here, the authors establish and validate two black yeasts as heterologous hosts for fungal polyketide discovery and production, combining the metabolic robustness of filamentous Aspergillus species wi...

doi.org

Black yeasts are efficient heterologous hosts for the production of a wide range of fungal polyketides - Nature Chemical Biology

Here, the authors establish and validate two black yeasts as heterologous hosts for fungal polyketide discovery and production, combining the metabolic robustness of filamentous Aspergillus species wi...

nature.com

Black yeasts emerge as hosts for fungal polyketide production - Nature Chemical Biology

Fungal polyketides represent a treasure trove of industrially relevant compounds, yet sustainable high-level production can be challenging. Black yeasts have emerged as promising heterologous hosts fo...

nature.com

Black yeasts are efficient heterologous hosts for the production of a wide range of fungal polyketides - Nature Chemical Biology

Here, the authors establish and validate two black yeasts as heterologous hosts for fungal polyketide discovery and production, combining the metabolic robustness of filamentous Aspergillus species wi...

nature.com

Polyketide synthase-based controlled synthesis of polycyclopropanated fuel molecules - Nature Communications

To be practically useful, sustainable aviation fuels need a suitable energy density and freezing point. Here the authors explore an iterative polyketide synthase family, leading to engineered biosynth...

nature.com

Scientists unlock fungi's secret chemistry, offering a greener path to crop protection

Pesky pests can wreak havoc on plants by chewing leaves, boring into stems, and sucking sap from trees. Beyond the direct damage, they also spread harmful bacteria, viruses, and fungi that can infect and ultimately kill the crops.

phys.org

Surveying hypocrealean fungi to identify biocontrol agents - Nature Chemical Biology

Hypocrealean fungi are the most important source of fungal and insect pest biocontrol agents. By integrating phylogenomics, metabolomics and synthetic biology, we surveyed the biosynthetic capabilitie...

nature.com

A biosynthetic survey of hypocrealean biocontrol fungi - Nature Chemical Biology

Crop losses from pests threaten global food security. Here, the authors survey the biosynthetic repertoire of hypocrealean fungi, identifying over 5,200 biosynthetic gene clusters, most encoding unkno...

nature.com

A biosynthetic survey of hypocrealean biocontrol fungi - Nature Chemical Biology

Crop losses from pests threaten global food security. Here, the authors survey the biosynthetic repertoire of hypocrealean fungi, identifying over 5,200 biosynthetic gene clusters, most encoding unkno...

nature.com

Synthetic biology for heterologous expression and engineering of fungal polyketide synthases

Covering: up to 2025Polyketide synthases (PKSs) are essential enzymatic systems that produce a wide range of natural products. Their biosynthetic features offer significant opportunities to create a…

pubs.rsc.org

Microbial chocolatiers of fine flavour - Nature Microbiology

A comprehensive assessment of biotic and abiotic features of cacao fermentation led to the design of a defined microbial consortium that could reproduce the fine flavour profile of chocolate under con...

nature.com

Black yeasts are efficient heterologous hosts of a wide range of fungal polyketides

Fungal natural products, including polyketides, are a rich source of bioactive molecules. Their biosynthetic enzymes are encoded within biosynthetic gene clusters, which are often activated by specifi...

researchsquare.com

getphylo: rapid and automatic generation of multi-locus phylogenetic trees - BMC Bioinformatics

Background The increasing amount of genomic data calls for tools that can create genome-scale phylogenies quickly and efficiently. Existing tools rely on large reference databases or require lengthy d...

bmcbioinformatics.biomedcentral.com

Pangenome mining of the Streptomyces genus redefines species’ biosynthetic potential - Genome Biology

Background Streptomyces is a highly diverse genus known for the production of secondary or specialized metabolites with a wide range of applications in the medical and agricultural industries. Several...

genomebiology.biomedcentral.com

Fungi oysters: Inside the Danish lab producing next alternative food

At a Technical University of Denmark lab, researchers are exploring the potential for fungi to be used as meat and seafood replacements.

euronews.com

StreptoCAD: An open-source software toolbox automating genome engineering workflows in streptomycetes

Streptomycetes hold immense potential for discovering novel bioactive molecules for applications in medicine or sustainable agriculture. However, high-throughput exploration is hampered by the current...

biorxiv.org

Development of a molecular genetics and cell biology toolbox for the filamentous fungus Diplodia sapinea

Diplodia sapinea (Fr.) Fuckel is a widespread fungal pathogen affecting conifers worldwide. Infections can lead to severe symptoms, such as shoot blight, canker, tree death, or blue stain in harvested...

journals.plos.org

ActinoMation: a literate programming approach for medium-throughput robotic conjugation of Streptomyces spp.

The genus Streptomyces are valuable producers of antibiotics and other pharmaceutically important bioactive compounds. Advances in molecular engineering tools, such as CRISPR, has provided some access...

biorxiv.org

A conserved bacterial genetic basis for commensal-host specificity

Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are...

science.org