WntUK
@wntuk.bsky.social
A network of UK based research groups with interests in the structural, molecular and cellular mechanisms of Wnt signalling in development and disease.
We're pleased to announce registration and abstract submission for the 3rd annual WntUK meeting at the @cruk-si.bsky.social in Nov 2026 is now open! Now featuring a bonus ECR day preceding the main meeting, ECR speaker slot, travel grants, networking opportunities and social evening. Book via QR 👇
Presenting the March 2026 WntUK newsletter! Containing exciting information about our plans for the WntUK annual meeting being held across 16-17th November at the CRUK Scotland Institute. Please send us your new WntUK papers, vacancies, and funding for inclusion in future editions!
Beautiful new UK Wnt paper out now in @natgenet.nature.com by Peter Hohenstein, Andrew Wood and Derya Ozdemir @unileiden.bsky.social @edinburgh-uni.bsky.social and Koc University characterising the impact of numerous CTNNB1 mutational variants in human cancer. www.nature.com/articles/s41...
Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling - Nature Genetics
Saturation genome editing of a cancer mutation hotspot in CTNNB1, the gene encoding β-catenin, reveals a gradient of effects of missense mutations on Wnt signaling.
nature.com
New UK Wnt paper out in @natgenet.nature.com from the Owen Sansom group at @cruk-si.bsky.social showing the RNA-binding protein NPM1 supports WNT-driven intestinal and liver tumorigenesis. www.nature.com/articles/s41...
Client Challenge
nature.com
Very grateful to receive a new BBSRC grant and many thanks to #BBSRC panel, and reviewers for this generous support. This funding will enable us to address important unresolved questions in chromatin regulation downstream of WNT/GSK3 signalling in stem cells. @wntuk.bsky.social
New posdoc position available in the Guettler lab @icr.ac.uk studying ADP-ribosylation in Wnt/B-catenin signalling and telomere maintenance 👇👇👇 jobs.icr.ac.uk/vacancies/12...
Postdoctoral Training Fellow: ADP-ribosylation in Wnt/β-catenin signalling and telomere maintenance in Chelsea | The Institute of Cancer Research
View details and apply for this Postdoctoral Training Fellow: ADP-ribosylation in Wnt/β-catenin signalling and telomere maintenance vacancy in Chelsea . Salary: Dependent on relevant Po...
jobs.icr.ac.uk
My next stop is CRUK Scotland in Glasgow. Thanks to Owen Sansom @cruk-si.bsky.social for hosting me. The @wntuk.bsky.social community is just awesome—great people, excellent research!
If you are interested in helping to organise and shape this event, I would love for you to join me!
WntUK@wntuk.bsky.social · last yr.Calling all WntUK ECRs! As the vision for a 2026 Wnt meeting takes shape we're planning a one-day ECR event. Interested in helping shape and organise it alongside our ECR rep @nadianasreddin.bsky.social? A great opportunity to connect, contribute, and develop your career. Get in touch!
Calling all WntUK ECRs! As the vision for a 2026 Wnt meeting takes shape we're planning a one-day ECR event. Interested in helping shape and organise it alongside our ECR rep @nadianasreddin.bsky.social? A great opportunity to connect, contribute, and develop your career. Get in touch!
Our latest work out now in Oncogene by Dr Megan Wagstaff at @biochembiomeduos.bsky.social @sussex.ac.uk @sussexcancer.org @sussexbcr.bsky.social @wntuk.bsky.social. We show the oncogene β-catenin interacts with a Wnt mRNA network in myeloid leukaemia cells Quick🧵👇 1/ www.nature.com/articles/s41...
β-Catenin interacts with canonical RBPs including MSI2 to associate with a Wnt signalling mRNA network in myeloid leukaemia cells - Oncogene
Oncogene - β-Catenin interacts with canonical RBPs including MSI2 to associate with a Wnt signalling mRNA network in myeloid leukaemia cells
nature.com
Major congrats to Dr#3 from our group Okan Sevim who passed his PhD viva yesterday. A super talented researcher, it’s been a privilege to serve as Okan’s supervisor from MSc to PhD in @biochembiomeduos.bsky.social @sussex.ac.uk Many thanks to examiners @mitchell.science & @mardakheh.bsky.social
As the sun sets on a wonderful day of celebrating @wntuk.bsky.social research, we want to thank all attendees, presenters and sponsors for making this possible. @oxfordcancer.bsky.social, The Company of Biologists, Cambridge Biosciences, @thermofishersci.bsky.social
Honoured and humbled to win Best Talk at #WNTUK2025! This work reflects years of dedication and a fantastic team effort, led by the amazing Hayley Belnoue-Davis and myself, under the brilliant Simon Leedham. Grateful to all—soon to be in press! 🚀
WntUK@wntuk.bsky.social · last yr.Congratulations to @eoghanjm.bsky.social from @ox.ac.uk on winning best talk, and Kieran Hodson from the Toby Phesse group at @cardiffuni.bsky.social @ecscri.bsky.social on winning best poster! #WNTUK2025
Thank you for the opportunity to contribute; what a fantastic meeting hosted at the inspiring Oxford, on the coolest signalling pathway.
WntUK@wntuk.bsky.social · last yr.Many thanks to @yatlasi.bsky.social from @qubelfastofficial.bsky.social for chairing the Disease and Translational Research session. #WNTUK2025
Really enjoyed #WNTUK2025 at @ox.ac.uk in beautiful Worcester College today. Excellent program of research talks and posters put together by @michaelranes.bsky.social and @oxfordcancer.bsky.social representing all themes, career stages and gender/diversity of @wntuk.bsky.social research. 👊
WntUK@wntuk.bsky.social · last yr.And that’s a wrap! @michaelranes.bsky.social draws a highly enjoyable, well organised and stimulating 2nd WNTUK meeting to a close, followed by drinks in the sun in front of a beautiful Worcester College lawn. See you next year! #WNTUK2025
And that’s a wrap! @michaelranes.bsky.social draws a highly enjoyable, well organised and stimulating 2nd WNTUK meeting to a close, followed by drinks in the sun in front of a beautiful Worcester College lawn. See you next year! #WNTUK2025
Congratulations to @eoghanjm.bsky.social from @ox.ac.uk on winning best talk, and Kieran Hodson from the Toby Phesse group at @cardiffuni.bsky.social @ecscri.bsky.social on winning best poster! #WNTUK2025
The final talk of the day is our international keynote speaker @michaelboutros.bsky.social from @dkfz.bsky.social @uniheidelberg.bsky.social presenting a past and present overview on mechanisms of Wnt signal transduction. #WNTUK2025
The penultimate talk of the day is our best selected PhD talk by Dr Ben Broadway from the Guettler lab at @icr.ac.uk presenting on CRISPR approaches to uncovering new tankyrase regulatory mechanisms in Wnt/B-catenin signalling. #WNTUK2025
Many thanks WntUK ECR rep @nadianasreddin.bsky.social from @cruk-si.bsky.social for chairing the Future Generation session! #WNTUK2025
The final session of the day is a Future Generation focus starting with invited ECR speaker Dr Yeonjoo Kim from the @ianmcgough.bsky.social group at @babrahaminst.bsky.social presenting on a novel RASopathy caused by hyperactive non-canonical Wnt signalling. #WNTUK2025
Final talk of the disease session is a selected abstract from Nico Mueller of the de la Roche group at @cambridgeuni.bsky.social @cruk-ci.bsky.social speaking about novel LGR5 immunotherapeutics against multiple cancer types. #WNTUK2025
Next up another selected abstract this time from Dr Nuray Gunduz at the Sansom group at @cruk-si.bsky.social presenting her research on LGR4 maintenance of intestinal homeostasis and protection from mutant-cell clonal expansion. #WNTUK2025
Many thanks to @yatlasi.bsky.social from @qubelfastofficial.bsky.social for chairing the Disease and Translational Research session. #WNTUK2025
The Disease & Translational Research session begins with invited speaker Dr @vivianlilab.bsky.social from @crick.ac.uk presenting on SOX2 driven fetal reprogramming and reversible dormancy in colorectal cancer. #WNTUK2025
Lunch break means it’s WntUK poster time! We have 17 fabulous posters here today covering Wnt signalling across mechanisms, development and disease from all career stages. #WNTUK2025
The final session before lunch is a selected abstract from Lee Placito Fellow of GI Cancer @eoghanjm.bsky.social from the @leedham-simon.bsky.social group at @ox.ac.uk speaking about GREMLIN1 role in stromal remodelling of Wnt-dependent ectopic stem niches in the intestine. #WNTUK2025
Taking us into the afternoon is the third selected abstract from Dr Ines Alvarez Rodrigo from the @jpvincentlab.bsky.social at the @crick.ac.uk presenting her research on Wnt secretion mechanisms at the membrane. #WNTUK2025
