Rhys Morgan
@rhysmorganlab.bsky.social
Associate Professor of Cancer Biology, School of Life Sciences, University of Sussex. Co-Director Sussex Blood Cancer Research, LMRUK Research Committee, Anthony Nolan stem cell donor and WntUK Co-Founder. https://www.sussex.ac.uk/lifesci/morganlab
We're pleased to announce registration and abstract submission for the 3rd annual WntUK meeting at the @cruk-si.bsky.social in Nov 2026 is now open! Now featuring a bonus ECR day preceding the main meeting, ECR speaker slot, travel grants, networking opportunities and social evening. Book via QR 👇
Great to see this finally online! Excellent work by first author Kate to continue our studies in LASP1 in HPV+ cervical cancers. Thanks to all authors @oncovirusleeds.bsky.social Miao (Kate) Wang, Yigen Li, Molly Patterson, James Scarth #HPV #cervicalcancer biorxiv.org/content/10.648…
biorxiv.org
Abstract submission deadline approaching fast (April 6th)!
Mick Milsom@milsommick.bsky.social · 5mo agoAbstract submission for the Mol Hem Workshop is now open here ehaweb.org/connect-netw... Submit for your chance to present your latest unpublished work in a highly visible session that forms part of the EHA annual meeting program in Stockholm.
RUNX1 aberrations in blast-phase CML induce the RBP SPATS2L which promotes growth, survival and stress granule assembly https://www.biorxiv.org/content/10.64898/2026.03.27.709496v1
RUNX1 aberrations in blast-phase CML induce the RBP SPATS2L which promotes growth, survival and stress granule assembly https://www.biorxiv.org/content/10.64898/2026.03.27.709496v1
Presenting our latest lab pre-print showcasing the research of Clinical PhD Fellow Dr David Palmer. We discovered novel dysregulated RNA-binding proteins (RBP) downstream of RUNX1 aberrations in blast phase-CML, including SPATS2L, which promotes growth and survival. www.biorxiv.org/content/10.6...
biorxiv.org
Delighted to share our latest work in @narjournal.bsky.social on the importance of (lnc)RNA–protein interactions in cell division, and how we identified RSRC2 as a new RBP involved in splicing and centrosome-associated RNA localisation academic.oup.com/nar/article/...
RSRC2 is a novel RNA-binding protein that safeguards mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1
Abstract. Mitotic fidelity requires proper chromosome alignment at the spindle equator, a process known as chromosome congression, mediated by well-establi
academic.oup.com
Presenting the March 2026 WntUK newsletter! Containing exciting information about our plans for the WntUK annual meeting being held across 16-17th November at the CRUK Scotland Institute. Please send us your new WntUK papers, vacancies, and funding for inclusion in future editions!
Less than two weeks remain to apply for the new Research Fellow post in our group! 👇👇👇
Rhys Morgan@rhysmorganlab.bsky.social · 6mo agoWe're hiring a new 3 yr postdoc! Join us for an exciting new CRUK funded project targeting RUNX1 mutations in CML in a highly supportive environment within @sussexbcr.bsky.social @biochembiomeduos.bsky.social @sussexcancer.org Apply👇, advert closes 8th March. jobs.sussex.ac.uk/job/4fee4e78...
🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41... RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10 #RNA #IDR #RBP
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6 - Nature Communications
LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...
nature.com
Join other cancer research students and early career researchers for a coffee, build a network, and connect with other researchers.
Multiple postdoctoral positions are available within the SCRC! Check them out and apply before the upcoming deadlines. sussexcancer.org/jobs
jobs — Sussex Cancer Research Centre
sussexcancer.org
We're hiring a new 3 yr postdoc! Join us for an exciting new CRUK funded project targeting RUNX1 mutations in CML in a highly supportive environment within @sussexbcr.bsky.social @biochembiomeduos.bsky.social @sussexcancer.org Apply👇, advert closes 8th March. jobs.sussex.ac.uk/job/4fee4e78...
Research Fellow in Biochemistry & Biomedicine Ref: 43149 (Fixed Term) - Job page - University of Sussex Job Search
jobs.sussex.ac.uk
Come join our lab in Sussex, UK for a PhD on TEs, on centromeres, on the genome ecosystem! Exciting times for TE:genome dynamics given the rate of T2T sequencing. Please circulate! www.findaphd.com/phds/project...
Evolutionary dynamics of transposable elements in the genome ecosystem of eukaryotes at University of Sussex on FindAPhD.com
PhD Project - Evolutionary dynamics of transposable elements in the genome ecosystem of eukaryotes at University of Sussex, listed on FindAPhD.com
findaphd.com
Come and join our vibrant PhD community with a doctoral project now available in the lab of Dr @abousios.bsky.social 👇👇👇👇
Alexandros Bousios@abousios.bsky.social · 6mo agoCome join our lab in Sussex, UK for a PhD on TEs, on centromeres, on the genome ecosystem! Exciting times for TE:genome dynamics given the rate of T2T sequencing. Please circulate! www.findaphd.com/phds/project...
Super strong representation from our department in SussexRNA at the RNA UK meeting in Windermere this week. Many congrats to Jake, Courtney and Hope from the Ben Towler group, and Leandro Castellano, Lidia Vasilieva, Ben and Nikos for having abstracts accepted for presentation. 👏
We’re having a ball! 🕺 💃 🥂 Well actually it’s the Sussex Life Sciences ball but kindly organised by the @sussex.ac.uk Biomed Society. 6th March 7.30pm till late at Leonardo Royal, all students and staff welcome! Get your tickets before they sell out 👇👇👇👇 sussexstudent.com/events/id/4942…
Professor Claire Smith joins Peter and Jane Dick on This Morning, to explain why more people are choosing to donate their bodies to science - and what it means for medical training and research. Watch here: www.youtube.com/watch?v=aZEu...
The Couple Donating Their Bodies to Science to Avoid Funeral Costs | This Morning
YouTube video by This Morning
youtube.com
We are hiring! We are looking for a Laboratory Scientific Officer to join our new group at The Cyprus Institute of Neurology & Genetics. Please share and feel free to message me for further details. The link for the advert is below cing.ac.cy/en/vacancies...
cing.ac.cy
We also have a PhD project available in the Tumour Virology group at The Cyprus Institute of Neurology and Genetics. Please feel free to contact me for further details. www.cing.ac.cy/education
Beyond pleased to announce our lab has secured its first @cancerresearchuk.org funding with an Early Detection & Diagnosis Project Award titled: 'Detecting and targeting translation inhibitor sensitive RUNX1 mutations in Chronic Myeloid Leukaemia' 1/5 www.cancerresearchuk.org/for-research...
cancerresearchuk.org
🔔New network opportunity!🔔 Prof @mitchell.science at @bsmsmedschool.bsky.social is advertising a new 3yr @leukaemiauk.bsky.social funded PDRA using mechanistic models to identify B-cell lymphoma therapeutic vulnerabilities. Expected start date: April’26 Apply👇by 01/03/2026 and join Sussex BCR!
Simon Mitchell@mitchell.science · 6mo agoWe’re excited to announce that we’re looking for a postdoctoral research to join our team! This is an opportunity to lead an exciting project aiming to push the boundaries of personalised medicine through integrating data, simulation and lab experiments. Plz share mitchell.science/talk/we-are-...
Huge congratulations to brand new Dr Jo Renaut from the Frances Pearl lab at @sussex.ac.uk who successfully defended her PhD thesis titled ‘Exploiting cancer vulnerabilities: A predictive approach to synthetic lethality via dependency mapping and metabolic disruption.’ 👏🎓👊
We’re excited to announce that we’re looking for a postdoctoral research to join our team! This is an opportunity to lead an exciting project aiming to push the boundaries of personalised medicine through integrating data, simulation and lab experiments. Plz share mitchell.science/talk/we-are-...
We are recruiting a postdoctoral research fellow. | Mitchell Lab
We're excited to announce that we're looking for a postdoctoral research to join our team!
mitchell.science
Very pleased to share our latest pre-print which showcases the incredible hard work and skill of Dr Okan Sevim. Our continued exploration of β-catenin's contribution to the post transcriptional landscape of blood cells led us to a LIN28B interaction. 1/7 www.biorxiv.org/content/10.6...
Dual targeting a LIN28B:β-catenin axis in acute myeloid leukaemia
Wnt/β-catenin signalling is dysregulated across several haematological malignancies, including acute myeloid leukaemia (AML), where is lacks effective targeting strategies. Previously, we discovered that β-catenin interacts with several RNA-binding proteins (RBP), and binds mRNA indirectly, indicating contributions to the post-transcriptional landscape of leukaemia cells. Here, we found the most frequent RBP-binding motif amongst β-catenin-bound mRNAs was the GGAG motif targeted by the oncofoetal expressed miRNA-regulating RBP LIN28B. We detected the β-catenin:LIN28B interaction in lymphoid and myeloid cell lines, and primary human CD34⁺ fetal liver-derived haematopoietic stem cells. LIN28B positively regulated Wnt signalling capacity by regulating LEF1 expression through a post-transcriptional mechanism requiring the let7 miRNA axis. Further miRNA sequencing of β-catenin- and LIN28B-depleted myeloid cells revealed both potential cooperative and antagonistic function in miRNA regulation. Finally, dual-targeting both β-catenin and LIN28B through either genetic or pharmacological means preferentially killed AML cells. These data reveal a potential novel synthetically lethal relationship in AML which could be exploited in the rare AML subsets where LIN28B expression becomes reactivated ### Competing Interest Statement The authors have declared no competing interest. Kay Kendall Leukaemia Fund, https://ror.org/03j2wfg84, KKL1051, KKL1446 Leukaemia & Myeloma Research UK, 4-5/06.21R Childrens Cancer & Leukaemia Group, CCLGA 2023 16 Morgan Republic of Türkiye Ministry of National Education
biorxiv.org
New UK Wnt paper out in @natgenet.nature.com from the Owen Sansom group at @cruk-si.bsky.social showing the RNA-binding protein NPM1 supports WNT-driven intestinal and liver tumorigenesis. www.nature.com/articles/s41...
Client Challenge
nature.com
Happy new year from Sussex Blood Cancer Research! If you’re an ambitious haematology scientist/clinician seeking Fellowships in 2026 to establish your own research lab why not consider @sussex.ac.uk Life Sciences as your host. Information, support and policy 👇👇 www.sussex.ac.uk/webteam/gate...
sussex.ac.uk
📖 Network pre-print notification!📄 New pre-print posted from @rhysmorganlab.bsky.social in @sussex.ac.uk led by Drs Hyun Park from @bsmsmedschool.bsky.social and Okan Sevim from @biochembiomeduos.bsky.social revealing a new regulator of leukaemia and stem cell growth; a deadenylase known as TOE1.
Rhys Morgan@rhysmorganlab.bsky.social · 8mo agoFresh from presentation at @ash.hematology.org #ASH2025, pleased to present our latest pre-print showcasing the hard work of Drs Hyun Park & Okan Sevim. Exploration of b-catenin’s post-transcriptional role has revealed a novel AML cell and stem cell regulator; TOE1. www.biorxiv.org/content/10.6...
Happy new year from Sussex Biochem/Biomed! If you’re an ambitious scientist/clinician in seeking Fellowships in 2026 to establish your own research lab why not consider @sussex.ac.uk Life Sciences as your host? Information, support and policy 👇👇 www.sussex.ac.uk/webteam/gate...
sussex.ac.uk
Fresh from presentation at @ash.hematology.org #ASH2025, pleased to present our latest pre-print showcasing the hard work of Drs Hyun Park & Okan Sevim. Exploration of b-catenin’s post-transcriptional role has revealed a novel AML cell and stem cell regulator; TOE1. www.biorxiv.org/content/10.6...
biorxiv.org