Our latest preprint: elevated MPS1 drives CIN in colon cancer by sustaining the fibrous corona at metaphase kinetochores. This untimely persistence creates an extra microtubule-engagement domain providing a structural basis for merotely and chromosome mis-segregation. doi.org/10.64898/202...

Everyone reduces dimensions. We reduced cells. Read our latest work on bioRxiv: Quantitative Description of C. elegans mRNA Landscapes From High Coverage Single-Cell Transcriptomes www.biorxiv.org/content/10.6...

🧵 I’m thrilled to share our new preprint! We uncovered a mechanism explaining how mitotic divisions are coordinated with early gene expression during embryogenesis. Here's the story: (1/7) www.biorxiv.org/content/10.6...

Cyclin B3-CDK1 couples translational de-repression to embryonic mitoses via OMA protein degradation in C. elegans.

During early embryogenesis, gene expression relies on maternally loaded mRNAs whose translation is controlled by RNA binding proteins. Here, we identify a critical role for the cyclin B3-CDK1 complex,...

biorxiv.org

📽️ G&D Tapes 📽️ G&D Author, Jeongmin An, tells us about how kinase STK38L serves as a negative regulator of Hippo signaling, and its implications for development and cancer. In this issue of #genesdev: ➡️ https://genesdev.cshlp.org/content/40/13-14/1080.abstract UC Irvine #Hippo #YAP #cancer

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: STK38/L promote tissue growth and cancer by inhibiting the Hippo pathway By An et al. and Wenqi Wang ➡️ https://ow.ly/FweF50Zae9J UC Irvine #Hippo #YAP #Drosophila #cancer

This is what amounts to an ILLEGAL & indiscriminate funding cut for research centers everywhere. It will mean shuttering labs across the country, layoffs in red & blue states, and derailing lifesaving research on everything from cancer to opioid addiction. We all need to speak out to save lives.

This is a full on assault on education. The US is the world leader in innovation research, technology only because we as a society support it. Without support for world leading research, we will brain drain and the best and brightest will go where research thrives www.statnews.com/2025/02/07/n...

NIH plans to slash support for indirect research costs, sending shockwaves through science

The NIH said Friday night that it would slash support for indirect costs on all existing and future grants to 15%

statnews.com

Inspired by this post, I'm hosting a phonebank at UC Irvine next week. Join if you're interested!

Annika Barber@annikabarber.bsky.social · 2y ago

Rutgers phonebank I helped organize got 25 people to call 3 legislators about NIH funding "pause." Most trainees and faculty were calling legislators for the first time ever, and said it was easier than expected! Happy to share resources if you want to get your lab/dept/student group to make calls.