Wing Yui Ngan

@yuingan.bsky.social

Wing Yui Ngan Postdoc @cam.ac.uk Interested in evolution, genomics, resilience biology, RNA, etc.

Tissues aren't static. They're evolving landscapes where mutant clones compete for dominance. Phylogenetics on somatic lineages, cross-species comparison across lifespans and steering clonal trajectories are exciting directions! @atjcagan.bsky.social's new comment www.nature.com/articles/s41...

How somatic evolution affects health - Nature Ecology & Evolution

As somatic evolution becomes directly measurable, integrating eco-evolutionary principles with high-resolution molecular data creates opportunities to anticipate and prevent disease.

nature.com

Summary: Lavisha found an IS inserted next to a deletion, and I found an IS inserted between two duplication fragments. Interestingly, both have no target site duplications identified. It suggested 1) IS element inserted in the DNA break, or 2) the Del or Dup was mediated by the IS transposase.

Lavisha Parab@lavishaparab.bsky.social · 2y ago

Our paper recently was published. It's about insertion sequences in relation to large scale DNA duplications and deletions. I'll try to write a summary soon but things are busy! Led by Jenna Gallie and Frederic Bertels. Guy and I learned a lot! Please share :D journals.asm.org/doi/10.1128/...