A big milestone for our group: the first research paper submitted! We found that cytosolic translation stress disrupts mitochondrial homeostasis and investigated cytosolic RQC and mitochondrial factors that save it. Preprint: www.biorxiv.org/content/10.6...

Really cool study! Few years ago one would say this was not possible...

Jan Philipp Kreysing@jpkreysing.bsky.social · 3w ago

Delighted that our story on chromatin architecture inside human cells is now published — the last chapter of my PhD. It was a pleasure working with @sergiocruzleon.bsky.social, @johannesbetz.bsky.social, and everyone involved. #teamtomo www.nature.com/articles/s41...

ER has a co-translational protein import mechanism known for decades. But how about mitochondria? Surprisingly, there is still a lot of debate about it! We wrote a comprehensive review on this topic. I hope it is useful :) onlinelibrary.wiley.com/doi/10.1002/...

Looks cool! A user friendly GUI tool to adjust and classify the cells detected by CellPose. github.com/biosustain/m...

Laborjournal@laborjournal.bsky.social · 2mo ago

Zellsegmentierung mit #KI klingt spannend – viele Forschende scheitern aber an der Komplexität. Das neue #OpenAccess -Tool Mycol soll Deep-Learning-basierte #Bildanalyse auch für Nichtexperten zugänglich machen – und setzt dabei auf einen „Human in the Loop“ … 👉 www.laborjournal.de/editorials/3...

This is a great meeting, and our group will be well represented with some new exciting results. There are still places, please spread the word!

EMBO@embo.org · 2mo ago

Register now for the EMBO Workshop "Advances and new frontiers in #ProteinTranslocation across membranes" in Sant Feliu de Guixols, Spain, 21–25 Sep 2026. Abstract submission/Registration by 19/30 Jun https://meetings.embo.org/event/26-protein-translocation #EMBOProteinTranslocation #EMBOevents 🧪

I applied for the US visa 1.5 years ago, they are still on it. Scientists are indeed a very dangerous category of people.

Congrats Higor, Maciej, Simo and Ahmad with this wonderful work!

Higor Rosa@hvdrosa.bsky.social · 3mo ago

Thrilled to share the updated video of my paper in Nature with Maciej (under supervision of @simonemattei.bsky.social & @jomaalab.bsky.social) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹🎉

I liked this classy and convincing paper from the Youle lab: intermembrane space endonuclease destroys escaped mtDNA. The escape happens during autophagy, and the vacuole is involved. How? To be determined. www.cell.com/current-biol...

The mitochondrial intermembrane space nuclease Nuc1 (endonuclease G) prevents mitophagy-mediated mtDNA escape in yeast

Cupo et al. find that Nuc1 nuclease activity and mitochondrial intermembrane space localization prevent mtDNA escape in yeast. In Nuc1 mutants, inducing mitophagy increases mtDNA escape, whereas inhib...

cell.com

Just submitted my first manuscript as an independent PI

It was a great pleasure to host Svetlana @dodonova-sveta.bsky.social as a guest lecturer at the @rptu.bsky.social. Thanks so much for your fascinating talk about archeal chromatin!

Together with @herrmannlab.bsky.social, we wrote this Preview in Mol Cell featuring a new study on the role of glutamine in cancer progression. I was also challenged to draw a "normal" figure. I think it came out nicely :) authors.elsevier.com/c/1mPZE3vVUP... doi:10.1016/j.molcel.2025.12.014

Check out the Highlight Issue of Biological Chemistry on the new avenues in organelle biology! I was very honoured to assemble it together with Emma Fenech. We devote it to our mentor Maya Schuldiner on the occasion of her anniversary. Enjoy! www.degruyterbrill.com/journal/key/...

This is the last week to apply!

GBM (Gesellschaft für Biochemie und Molekularbiologie)@gbmev.bsky.social · 10mo ago

Starting your own lab is exciting—but challenging. Join our GBM Young Investigator leadership workshop in Regensburg, April 13–16th, 2026. Professional coaching, peer networking & practical tips for new PIs. Apply by Nov 30, 2025. 👉 gbm-online.de/de/young-inv... Pls repost!

Junior professor position at the University of Kaiserslautern! Our Department of Biology is seeking a colleague working with microalgae. This is a wonderful place to do wonderful science with great people! Please, repost :) Further details: jobs.rptu.de/jobposting/1...

Very thorough work that applies cryo-ET to measure bilayer thickness. Surprisingly, the missing wedge is not a big problem!

Journal of Cell Biology@jcb.org · 9mo ago

Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...

Attention new PIs! Here is a workshop to develop as a mentor and project leader, meet your peers and exchange experience. Please repost!

GBM (Gesellschaft für Biochemie und Molekularbiologie)@gbmev.bsky.social · 10mo ago

Starting your own lab is exciting—but challenging. Join our GBM Young Investigator leadership workshop in Regensburg, April 13–16th, 2026. Professional coaching, peer networking & practical tips for new PIs. Apply by Nov 30, 2025. 👉 gbm-online.de/de/young-inv... Pls repost!

Registration open: 77. Mosbacher Kolloquium "More than lipidic barriers - New horizons in membrane biology" from March 25-28, 2026 lnkd.in/dgsW4c3 Scientific Organizers: Britta Brügger, Robert Ernst, André Nadler, Christian Ungermann Early registration & poster abstracts until January 31, 2026

Here is my take on the two recent papers by Shu-ou Shan and Jonathan Weissman labs. It appears that there might be 'signal inhibition' instead of 'signal recognition' for the mitochondrial proteins in the cytosol. www.sciencedirect.com/science/arti...

Din Baruch, Maya Schuldiner, Ofir Klein and colleagues create and validate a proteome-wide yeast library for protein detection and analysis. journals.biologists.com/jcs/article/... #OpenAccess #ReadandPublish

A very cool paper from Shu-ou Shan's lab defines a range of mitochondrial proteins that are imported co-translationally: unexpectedly late recruitment, and evidence for my favourite hypothesis of active inhibition of co-translational import into mitochondria! www.cell.com/cell/abstrac...

Principles of cotranslational mitochondrial protein import

Selective ribosome profiling reveals that nearly 20% of mitochondrial proteins in human cells are imported during translation on cytosolic ribosomes. Cotranslational import requires an N-terminal pres...

cell.com

Imagine being an Israeli scientist: you protest the war in Gaza every week, your institute gets bombed, and then the EU cancels your funding in a move that achieves nothing but makes some people in Europe feel morally superior and 'doing the right thing'.

Thiago Carvalho@cyrilpedia.bsky.social · last yr.

'Horizon Europe is among the most prestigious science research programmes in the world and has never suspended a country before. Officials believe, however, the humanitarian crisis in Gaza is so severe that it now has a legal basis for suspension.'

Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!! Make my day and check it out! www.biorxiv.org/content/10.1... #Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬

The first-ever group trip! This week we visited @simonemattei.bsky.social group at EMBL Heidelberg for a seminar and dinner. Thanks so much for the fantastic day!

Recently we discussed at lunch how can molecular biology be brought closer to organismal biology. I remembered this awesome work from Nikolai Sluchanko's lab. Why are grasshoppers green? New, dual-chromophore protein discovered by classic protein purufucation. www.pnas.org/eprint/YMXEU...

A green dichromophoric protein enabling foliage mimicry in arthropods | PNAS

Molecular mechanisms underlying the green insect camouflage have puzzled researchers for over a century. Here, we isolated and identified a green w...

pnas.org

Svetlana Dodonova@dodonova-sveta.bsky.social · last yr.

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social! www.biorxiv.org/content/10.1... #Chromatin #Asgard #Archaea #cryoEM

Yeast labs. Beware!

Yeast Journal@yeast-journal.bsky.social · last yr.

In the latest #Yeast research article of the series #FantasticYeasts, Pei-Jie Han, Feng-Yan Bai & team describe a new yeast species isolated from a Chinese forest: Saccharomycopsis yichangensis, that can prey on Saccharomyces cerevisiae and other yeasts 😲 onlinelibrary.wiley.com/doi/10.1002/...

A very exciting day for every yeast genetics lab! Our ROTOR+ from Singer Instruments arrived and was installed. Tons of plans and ideas!

🚨New preprint!🚨 #teamtomo We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles. Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

Surface morphometrics reveals local membrane thickness variation in organellar subcompartments https://www.biorxiv.org/content/10.1101/2025.04.30.651574v1

The fact that BLAST considered all possible spellings is nice and funny. What's your favorite?

It was the greatest pleasure to host @sheinerlab.bsky.social as a visiting lecturer this week and hear the new fascinating story on Toxoplasma mitoribosome! Thank you, Lilach!