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Katie Downes

@dr-downes.bsky.social

Post Doc @ Francis Crick Institute and UCL - COPII, CryoCLEM, cats, mammalian secretory pathway, image analysis

19 Posts603 Follower552 Folgt
Ben Engel@cellarchlab.com · 7y ago

We're looking for an awesome computational #postdoc to join our group @PioneerCampus. You'll explore native cells with #cryoET, get long-term funding (5+ years), and live in Munich! For more info, see our new Cell Architecture Lab website:...

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Katie Downes@dr-downes.bsky.social · last yr.

I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com. Check it out here! rdcu.be/eeY1J #COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES

Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway

Nature Reviews Molecular Cell Biology - Coat protein complex II (COPII) subunits assemble to form membrane transport carriers at ER exit sites, thereby concentrating secretory cargoes and...

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Katie Downes@dr-downes.bsky.social · 2y ago

Lets play... What Am I Looking At?? Low mag tomogram of milled RPE-1s. Any guesses of whats going on here? #TeamTomo Prize? idk... bragging rights? The feeling of superiority? I'll collect a high mag tomo tomorrow, so the answer may actually be revealed! (mysteries mysteries mysteries).

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Ferdos Abid Ali@abidalilab.bsky.social · 2y ago

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪

This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.
MRC-LMB Cell Biology Division@cellbiol-mrclmb.bsky.social · 2y ago

This year’s UK Membrane Trafficking Meeting is on Dec 16th at King’s College London (Guy’s Campus, London Bridge). Registration closes 9th December. Sign up is here. estore.kcl.ac.uk/conferences-... Thanks go to @J_Cell_Sci for sponsoring student/postdoc prizes!

UK Membrane Trafficking Meeting 2024 | King's College London eStore

Registration for the 2024 UK Membrane Trafficking Meeting, held at KCL.  Registration per person, to include sandwich lunch and coffee breaks and even

estore.kcl.ac.uk