We caught a chemically-driven molecular shuttle in the act! 🤫 Read @angewandtechemie.bsky.social how we use optical-tweezers with @3mlab.bsky.social to track how a two-station shuttle becomes a single-station rotaxane upon Diels-Alder reaction! onlinelibrary.wiley.com/doi/10.1002/...

Hey there Bluesky! Postdoctoral position in Single-Molecule Biophysics of Mitochondrial DNA Replication still open! ☺️ An interdisciplinary effort to uncover mitochondrial replisome dynamics and the molecular origins of disease-related mutations @imdeananociencia.bsky.social 👇👇

The position will stay open untill we find the rigth candidate.

We are hiring! We're looking for a Postdoctoral Researcher to explore the dynamics of human mitochondrial DNA replication at the single-molecule level. Review the details below👇or visit borjaibarralab.com 💻

A una molecula le "cuesta" lo mismo subir que bajar la barrera energética entre dos estados metaestables. @emiliomperezlab.bsky.social @3mlab.bsky.social lo observan por primera vez en nanomaquinas moleculares 👉 phys.org/news/2025-02...

Optical tweezers reveal forward and backward motion is symmetric in molecular shuttling

In molecular shuttles, a ring molecule is threaded onto a linear molecular strand and can move between two portions of the strand, called stations, in response to external stimuli. Chemical stimuli, l...

phys.org

Ismael Plaza defended successfully his thesis "In Singulo characterization of the real-time kinetics of the human mitochondrial DNA replisome", directed by Prof Borja Ibarra @3mlab.bsky.social @imdeananociencia.bsky.social 🎓 Congratulations Doctor!

Paper with @emiliomperezlab.bsky.social and @3mlab.bsky.social et al. in print! Experimental energy landscape calculated (journals.aps.org/pre/abstract...) from the Onsager-Machlup approach for systems in mechanical but not necessarily thermodynamic equilibrium. www.cell.com/chem/fulltex...

Transition-path times of individual molecular shuttles under mechanical equilibrium show symmetry

This study explores microscopic reversibility to understand the operation of molecular devices.

cell.com

Fresh off the press! Read our latest article with @3mlab.bsky.social and @deanast.bsky.social just out at Chem @cellpress.bsky.social! www.sciencedirect.com/science/arti... #ChemSky #SciSky #PhySky #molecularmachines 1/5

Transition-path times of individual molecular shuttles under mechanical equilibrium show symmetry

Measuring individual trajectories during the operation of synthetic devices is crucial for a thorough understanding of this operation. Here, we use op…

sciencedirect.com

We are hiring! We're looking for a Postdoctoral Researcher to explore the dynamics of human mitochondrial DNA replication at the single-molecule level. Review the details below👇or visit borjaibarralab.com 💻

🔴⚠CNIO-CaixaResearch Frontiers Meetings: Machines acting on DNA and RNA, a molecular mechanistic perspective. 📆May 28-30th 👥 @oscarllorca.bsky.social, @rfleiro.bsky.social and @nogaleslab.bsky.social. 🔗https://www.cnio.es/eventos/machines-acting-on-dna-and-rna-a-molecular-mechanistic-perspective/

Single molecule approaches across the central dogma! Genomics, imaging and theory! Very excited to host the first edition of Gene regulation, one molecule at a time this July @embl.org! Great lineup and many abstract selected talks!

EMBL Events@events.embl.org · 2y ago

📣 #EMBLSingleMolecule is open for registrations! Our aim is to catalyse the emergence of a new generation of mechanistic models of the regulation of genes across each steps of the central dogma. 🧬🔍 👉🏼 s.embl.org/grg25-01-bl 📅 15 – 18 July 2025 📜 Submit your abstract by 8 April!

What a way to start 2025! Our review on the Known Unknowns of the Hsp90 Chaperone has been published! Huge thanks to Laura Silbermann and Benjamin Vermeer for all of their efforts, and to @scisonja.bsky.social for the great collaboration :) You can read it here: elifesciences.org/articles/102...

The known unknowns of the Hsp90 chaperone

An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.

elifesciences.org

First paper of our lab today @natureportfolio.bsky.social by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping! @embl.org #RNAbiology #RNASky t.co/a24Xxcxdo0