starting to understand the structural bases of CONCR lncRNA in DNA replication / chromatid cohesion. A collaboration between @maitehuartelab.bsky.social @oscarllorca.bsky.social Moreno-Herrero at @cnb-csic.bsky.social and Chillon at @igmm-montpel.bsky.social, and the support of @lacaixa.bsky.social

Molecular Cell@cp-molcell.bsky.social · last mo.

Online Now: CONCR lncRNA organizes a 3′-end structural domain that engages DDX11 for DNA replication and sister chromatid cohesion Online now:

CONCR lncRNA organizes a 3'-end structural domain that engages DDX11 for DNA replication and sister chromatid cohesion pubmed.ncbi.nlm.nih.gov/42664968/ #cryoEM

Congratulations to Pablo San Segundo Acosta, Johanne Le Coq, Jasminka Boskovic, Robin Aglietti, Peter Bowers, Todd Yeates and everyone involved! Also big thanks to Pablo Guerra from the cryo-electron microscopy platform at the electron microscopy center of the ALBA Synchrotron for the Glacios data!

Excited to share our latest research on leveraging machine learning with helical fusions for the design of novel protein cages! Preprint: “Design and structure of protein cages based on helical fusion and machine learning” Link: www.biorxiv.org/content/10.6...

Structural basis of human γTuRC closure during CM1-activated microtubule nucleation pubmed.ncbi.nlm.nih.gov/41888131/ #cryoEM

Have a look at our latest results on #CDK regulation, just posted as a pre-print! This study was spearheaded by PhD student Amy McGeoch. Amy has determined the #cryoEM structure of the CDK11-cyclin L-SAP30B complex, an important regulator of #spliceosome activation. www.biorxiv.org/content/10.6...

A closer look at the mechanism of microtubule nucleation💫. Thrilled to share our new work revealing CM1-activated gTURC. Great collaboration with Marina Serna, Claudia Brito, Jens Lüders and Thomas Surrey. @cniostopcancer.bsky.social @crg.eu @irbbarcelona.org www.nature.com/articles/s41...

8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷 Get ready for Machines on Genes 2026, the 94th Harden Conference by the @biochemsoc.bsky.social — four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️ Organised by @lapassmore.bsky.social, Dana Branzei, me.

🌞✈️🇬🇷🏝️ 🧬 Machines on Genes 2026 🧬 🌞✈️🇬🇷🏝️ What an amazing list of speakers 🤩 @nynkedekkerlab.bsky.social @dodonova-sveta.bsky.social @yuanhejhu.bsky.social @uwmadisonrna.bsky.social @kowaeva.bsky.social @fmattiroli.bsky.social @aliciakmichael.bsky.social @lisaracki.bsky.social @yeeles-lab.bsky.social

We’re excited to share our latest preprint on the mechanism of excised linear intron stabilization in yeast! This work was led by PhD student @glennli.bsky.social and was a wonderful collaboration with @maxewilkinson.bsky.social. Link: www.biorxiv.org/content/10.6... (1/4)

El CNIO presenta su Plan de Actuación para orientar su futuro a las áreas hoy más prometedoras en la investigación del cáncer www.cnio.es/noticias/el-...

I’m very happy (and grateful!) to share that I’m featured in a Nature Cancer Viewpoint about starting my lab at CNIO. In the Lab (www.rcglab.com) we’re combining AI, protein design and structural biology to study protein structures and design novel protein therapeutics for cancer. 🔬

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...

Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase

Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...

science.org

It always surprises me when I encounter scientists with a religious faith. Very rare amongst biologists in my experience, but more common amongst astronomers. I guess it’s possible to fantasise about a creator if you don’t understand evolution.

Kickstarting our Bluesky🦋 account with great news! Our REPAIRome study finally out today in @science.org www.science.org/doi/10.1126/...

A comprehensive genetic catalog of human double-strand break repair

The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

science.org

We’re looking for an enthusiastic postdoc to join our team. 😊 The project focuses on protein design and cryo-EM applied to cancer research. 🔬🧪 The position is fully funded for 3 years. Please share 🙏 Job description and application details (deadline: October 11th): www.cnio.es/en/empleo/po...

Postdoctoral Research Assistant for the Biomolecular Design and Structural Nanomedicine Group

DescriptionWe are looking for a Postdoctoral Researcher to join Roger Castells-Graells’ lab at the Spanish National Cancer Research Centre (CNIO). The successful candidate will work on innovative biom...

cnio.es

Exciting new study from new-PI Mohinder Pal on the role of CCDC103 and it's links to PCD as the most recent dynein assembly factor (DNAAF19). Congratulations to the entire team. @Mohinder Pal (currently not on Bluesky) @mike-wieczorek.bsky.social @laurencepearl.bsky.social

UK Cilia and Centrosome Network@ukcilianetwork.bsky.social · last yr.

New pre-print on the role of CCDC103/DNAAF19 in dynein assembly highlighting it's link to PCD. www.biorxiv.org/content/10.1...

A team at #CNIOStopCancer finds a new cause for idiopatic pulmonary fibrosis: a mutation in gene POT1, which hinders tissue from regenerating. This makes breathing increasingly difficult in this potentially fatal disease currently without treatment  http://bit.ly/41MPOAB

Thrilled that our work is now finally out in Nature Comms! rdcu.be/eG3vP We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres. Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!

Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳 How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look. www.cell.com/structure/fu...

Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps

Lövestam and Scheres present a cryo-EM structure of vault particles, found during tau filament extraction from progressive supranuclear palsy (PSP) brain tissue. They reveal a symmetry shift at the va...

cell.com

Highly collaborative efforts that involved 6 lab members and the labs of @yiliangding.bsky.social and @rdaslab.bsky.social. We uncovered a telomerase dimer and its potential role in telomere maintenance.

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · last yr.

Sebastian Balch, Zala Sekne & Elsa Franco-Echevarría in @kellythd-nguyen.bsky.social's group have confirmed the existence of dimeric telomerase and illustrated how it is key to telomere maintenance: www2.mrc-lmb.cam.ac.uk/first-struct... #LMBResearch @yiliangding.bsky.social @rdaslab.bsky.social 🧪

🧬 #CIDHD25 will bring together experts exploring how cells maintain genome stability & how these insights are driving new therapies. 4 days of exciting talks, plus lots of opportunity for networking! 🗓️ Poster & Reg Deadline: 14 Aug 🔗 bit.ly/44mBPU2 #FusionCellBio #FusionDNA

Very grateful for receiving a Short Talk Award at #CFM_MolMech Thanks to the organisers for putting together such an amazing conference! @oscarllorca.bsky.social @rfleiro.bsky.social @nogaleslab.bsky.social @cniostopcancer.bsky.social

Basil Greber@bjgreber.bsky.social · last yr.

Delighted to hear that post-doc @natalia-mg.bsky.social has received the Short Talk Award for her #cryoEM studies of DNA repair at the conference on "Machines Acting on DNA and RNA, a molecular mechanistic perspective" at CNIO Madrid. Congratulations, Natàlia! Photo courtesy of @amunts.bsky.social.

Great work highlighting how important it is to carry out experimental structure determination instead relying on AlphaFold predictions. #crystallography #structure #biology #chemistry www.nature.com/articles/s41...

AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods

An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...

nature.com

Muñoz-Hernández, Xu, et al. @mike-wieczorek.bsky.social @ethz.ch report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs rupress.org/jcb/article/...

Speakers at #CNIOSeminars share innovative advances from the fields they lead. We have recently wellcomed:👇 1️⃣ Raman van Wee, from @oxfordchemistry.bsky.social. As @oscarllorca.bsky.social 's guest, he talked about the rol of protein Ku7080 in repairing double strand breaks in DNA

Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ @natcomms.nature.com BRCT domain in recruitment and activity of two Pol X members in NHEJ: a unified model for the interaction of Pol X with Ku70/80. www.nature.com/articles/s41...

Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ - Nature Communications

The molecular basis for the enrollment of X family DNA polymerases in non-homologous end joining (NHEJ) is unclear. Here the authors elucidate the structure of Pol λ within the DNA-PK long-range compl...

nature.com

Europe will always stand for science and the freedom to learn and invent. As of 11 am, tune in, and discover how the @ec.europa.eu wants to help the best and brightest ‘Choose Europe’. → europa.eu/!Tx43kH

The fourth session of #CFM_MolMech at #CNIOStopCancer will bring latest research on the specifity of RNA decay, the RNA exosome and macromolecular complexes in DNA processing. With @lapassmore.bsky.social , @cellbiol-mrclmb.bsky.social  Gina Buchel, @yale.edu  Elena Conti, @mpibiochem.bsky.social

The registration deadline for #CFM_MolMech is around the corner! 🔴May 5th, 20205🔴 📅Join us on May 28th - 30th at #CNIOStopCancer 🏃‍♀️Don't miss the opportunity! Read about the 4th session on the 🧵👇 With the support of CaixaResearch. 🔗More info: bit.ly/42hyRh0