Ana Coelho Almeida
@ac-almeida.bsky.social
Postoctoring in🇨🇭@ivanagasic.bsky.social Lab Cell biologist #Cytoskeleton & #Microscopy enthusiast 🔬🧫
👏Congratulations @ivanagasic.bsky.social 's group for your latest publication in @natcomms.nature.com showing how protein excess tips the balance of cellular health #tubulin @mocel.bsky.social @sciencesunige.bsky.social @ac-almeida.bsky.social www.unige.ch/medias/en/20...
Hot off the press!! 🚨 Our work is now published in #NatureCommunications! We show that keeping tubulin levels in check is key for preserving microtubule dynamics, multicellular architecture and viability. A huge thank you to the @ivanagasic.bsky.social team for making this possible! 🙌 rdcu.be/fu8ek
Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability
Nature Communications - Almeida AC et al. uncover the physiological role of a long-elusive feedback pathway that regulates tubulin biosynthesis. By tuning microtubule dynamics, this mechanism...
rdcu.be
Heading to #CellBio2025 @ascbiology.bsky.social @embo.org? Stop by my poster P0101 tomorrow (Sun, 12:45 PM) in the session “Cytoskeleton and Motility-Microtubule Organization and Dynamics”. Looking forward to lively discussions on tubulin regulation & microtubule organization. See you in Philly!
And now… part two of our twin papers on how chromosomes find their place before division! Led by @krunovuk.bsky.social at @institutrb.bsky.social, out in @natcomms.nature.com! doi.org/10.1038/s414... doi.org/10.1038/s414... Missed the thread on the first paper? Catch up: bsky.app/profile/ivat...
Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...
Structure and assembly of the A-C linker connecting microtubule triplets in centrioles
Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.
science.org
🚨 New preprint out! “Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies. www.biorxiv.org/content/10.1...
Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM
Flipper-TR is a membrane dye sensitive to lipid packing widely used to probe membrane tension in live cells via fluorescence lifetime imaging microscopy (FLIM). However, no consensus currently exists ...
biorxiv.org
Can’t wait for the BioMatter Meeting in beautiful Arolla 🇨🇭⛰️ Amazing lineup of speakers + cutting-edge science on cytoskeleton dynamics from cells to tissues. See you there!
Life Sciences Switzerland (LS2)@lifesciswitzerland.bsky.social · last yr.📢 Last days to Join Arolla 2025! 📅 Aug 25–29, Grand Hotel, Arolla 🌍 For junior & senior scientists in cutting-edge bio research 🧬 Abstracts + reg close August 11 💸 Discounts for LS2 members! 👉 Info & reg: meetings.ls2.ch/arolla2025
🔎New preprint! We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture. Big thanks to @ivanagasic.bsky.social and team! Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5) www.biorxiv.org/content/10.1...
Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability
Alpha- and beta-tubulin heterodimers dynamically assemble into microtubules, key cytoskeletal elements involved in intracellular trafficking, cell adhesion and division. The availability of free tubul...
biorxiv.org
EMBO Fellows Meeting 2025 just wrapped up! 4 intense days, 110+ talks, amazing postdocs, mentoring & networking! Huge thanks to @embo.org & the organizers 👏 Feeling proud to be part of the next gen of scientists ready to push science forward. Sharing a few highlights 📸
📢We are live everyone ! ! ! We are happy to announce that our official WEBSITE is now online - and early bird registration is OPEN 🎉 👀👇Come check it out🚀🌟 spaom2025.org 🚩Braga, Portugal 📅November 5-7, 2025 #microscopy #science #bioimaging #advancedmicroscopy #spatialbiology #photonics
Two cells, one twist 🧬🔁 Myosin asymmetry breaks mirror symmetry & sparks spontaneous 3D rotations in doublets. Adherens junctions🩶, focal adhesions🟢 & actomyosin🔴 Biology meets active matter physics. #CellPolarity #Fluorescencefriday #ActiveMatter #Microscopy
Did you know the cell wall of mycobacteria isn’t just for protection? 🧱👀 Here, Mycobacterium marinum sheds its outer capsule right after being eaten by Dicty! A sneaky move that affects even nearby cells… #FluorescenceFriday #Mycobacteria #CellBiology #Infection #3Rmodels #Phagocytosis
New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...
🔬 A new probe developed by Janelia researchers & collaborators that enables visualization of extracellular matrix structure in live tissues could also be useful in studying diseases linked to changes in the extracellular matrix and in diagnostic imaging ➡️ www.janelia.org/news/looking...
This stunning image was made by @ac-almeida.bsky.social , our brilliant President and microtubule enthusiast! She's passionate about how the cytoskeleton organizes itself in 3D—seriously cool stuff! 🧠🧵✨#Microscopy #WomenInSTEM #Cytoskeleton @mocel.bsky.social
Behold: a human cancer spheroid! This 3D cell blob models solid tumors. DAPI (blue) marks nuclei, PI lights up the dead. Z-plane colors unveil a rainbow necrotic core wrapped in a moody, monochrome outer layer. #fluorescencefriday #microscopy #postdoc
