New article from Emmanuel Levy'Lab : they discovered that missense mutations in homomeric proteins can trigger supramolecular assembly but, remarkably, these folded protein assemblies are not toxic. A testament to cellular robustness!
Emmanuel Levy's lab@elevylab.bsky.social · 11mo agoYears ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
