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Adam Fountain

@adamfountain.bsky.social

PostDoc in the Ramakrishnan/Luisi labs at University of Cambridge. Bedaquiline resistance in Mycobacterium tuberculosis #ENDTB

11 Posts56 Follower234 Folgt
Lucy Weinert@lucyweinert.bsky.social · 8mo ago

savethevetschool.co.uk Colleagues, please lend us your support. The University wants to close down the vet school despite being ranked educationally above school average and smashing the REF because they want our land and vet education is too expensive.

Save the Vet School - join 1000s of voices standing with the Vet School

A vital institution. A community in action. A future worth protecting. Stand with us to save the vet school.

savethevetschool.co.uk

Jamie Blaza@jnb-lab.bsky.social · 8mo ago

Our work on the mechanism of bedaquiline is now published. Nat Comms has open peer review so anyone can see the critical but constructive and supportive peer review we received. Thanks again to @morwan.me on BlueSky, and Suzy, Rowan, Greg, Chen-Li, and Roger who aren't. Original thread below

Clockwork@watchclockwork.com · last yr.

🦠 NEW VIDEO 🦠 The molecular biology of how Mycobacterium Tuberculosis evades the immune system so well. Starting with this simulation of a full outer envelope of m.TB--let's explore how the deadliest & most persistent human pathogen completely hacks our immune response. #molecularbiology

Adam Fountain@adamfountain.bsky.social · last yr.

Bedaquiline resistance driven by the MmpS5L5 efflux pump is threatening the drug regimens used to treat MDR-TB. In our new preprint, we used structural and genetic approaches to better understand how MmpS5L5 effluxes bedaquiline and how future resistance may evolve. 🧵🔽 #TBsky #MicroSky #TB

Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance

Bedaquiline, an antitubercular drug that targets ATP-synthase, is a key component of a new oral drug regimen that has revolutionized the treatment of multi drug resistant tuberculosis. Clinical bedaqu...

biorxiv.org

Rock Lab@rocklabtb.bsky.social · last yr.

Challenging times for biomedical research in the U.S. One of our grants was terminated and two others frozen. Thinking of colleagues from Bethesda to Boston to South Africa who are facing the same uncertainty. Now more than ever, we must speak up for the value of this work.

Renee DiResta@noupside.bsky.social · 2y ago

Lysenkoism was a Soviet-era pseudoscientific movement led by Trofim Lysenko, and endorsed by Stalin. It rejected established genetics science in favor of politically driven, unproven agricultural theories and ideological loyalty, leading to widespread crop failures and famine.

The Atlantic@theatlantic.com · 2y ago

The CDC’s Advisory Committee on Immunization Practices is currently stacked with academic experts well versed in the science of vaccines. A new secretary of Health and Human Services could rapidly change that, Katherine J. Wu writes. theatln.tc/BQ7rbFmn

Saloni@scientificdiscovery.dev · 2y ago

Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly. Just how many types of antibiotics were discovered during that time? So, I visualized it myself!

A timeline titled "The Golden Age of Antibiotics" shows when each antibiotic drug class was first available for medical use, with example antibiotics labeled. Classes are color-coded by their source: actinomycetes, other bacteria, fungi, or synthetic. Milestones include the first antibiotics (arsphenamines in 1910), as well as the discovery of many actinomycetes-derived antibiotics, such as streptomycin, and sulfonamides, penicillins, and tetracyclines. Data: Hutchings, Truman, Wilkinson (2019). Created by Saloni Dattani for Our World in Data.
Morwan Osman@morwan.me · 2y ago

Our first TB preprint with @jnb-lab.bsky.social is out! Using spectroscopic techniques from our lab, we resolve the exact mode of action of everyone's favourite TB drug, bedaquiline. I'd like to add a few comments about the microbiology part of the picture! #TBsky #MicroSky (1/7)

Jamie Blaza@jnb-lab.bsky.social · 2y ago

Finally we are able to share our story on the molecular mechanism of the transformative anti-tuberculosis drug bedaquiline within living cells www.biorxiv.org/content/10.1... A (hopefully) broadly-accessible tutorial below ⬇️ (it ended up being really long!)

Jamie Blaza@jnb-lab.bsky.social · 2y ago

We have quite a range of PhD projects this year, covering cryo-EM methods, bacteriology/bioenergetics, and infection/antibiotics/vaccines. Would really appreciate if people can RT and share with their teams!