🔥Out now in @cellcellpress.bsky.social Dietary arginine deficiency represses MHC-I translation via tRNAs & codon-usage, repressing anti-viral & anti-tumor immunity in CRC. Arginine supplementation drives MHC1, improves antiviral and anti-tumor immunity. by amazing Q Wu🧵👇 www.cell.com/cell/abstrac...

Dietary arginine drives codon-dependent MHC class I translation and improves immunity in colon tumorigenesis and respiratory viral infection

Arginine availability regulates arginyl tRNA levels and codon-dependent translation of MHC class I, tuning antigen presentation and shaping anti-viral and anti-tumor immunity.

cell.com

@qiushuang-wu.bsky.social · 6d ago

Thank you for highlighting the paper! Dietary arginine drives codon-dependent MHC class I translation and improves immunity in colon tumorigenesis and respiratory viral infection: @cellpress.bsky.social Cell www.cell.com/cell/fulltex.... Huge thanks to my postdoc mentor @sohailtavazoie.bsky.social

Please repost! #microsky🦠 The Glickman Lab at MSK is recruiting! Projects in Mtb pathogenesis, basic biology of mycobacteria, and mycobacterial cancer therapies. See our publications here: tinyurl.com/3f386f4x Send CV and cover letter to: glickmanmycolab@gmail.com

🌟 We're hiring! We're looking for enthusiastic and innovative postdoctoral fellows who are passionate about #immunology and #InfectiousDisease to join our collaborative team at UMass Amherst! #AlveolarMacrophages #TB #lung #InnateImmunity Apply now! careers.umass.edu/jobs/post-do...

Post Doctoral Research Associate - Rothchild Lab - Amherst, Massachusetts, United States

Title: Post Doctoral Research Associate - Rothchild Lab Executive Area: Academic Affairs College/School/MBU: College of Natural Sciences Department: Veterinary & Animal Sciences Work Location: Amh...

careers.umass.edu

We're hiring an enthusiastic and ambitious technician to unravel the mysteries of spirochetes (#Lyme #syphilis). Come be a part of a wonderful team and working enviro in beautiful Chicago! Looking for training micro, molec, cell, or glycobiology of pathogens?👇 myhr.northwestern.edu/psp/hrnu/EMP...

Congrats @jasonyanglab.org!

Jason Yang@jasonyanglab.org · last mo.

I'm thrilled to share that the lab has received its first R01!! Together with Shuyi Ma and Christoph Grundner, we will be exploring how M tuberculosis gene networks regulate drug tolerance. More soon, but we will be recruiting postdocs and graduate students!

Out Now! Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning #MicroSky

Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning

Nature Microbiology, Published online: 30 June 2026; doi:10.1038/s41564-026-02412-5Screening 1,572 compounds for mycomembrane permeation plus cheminformatic and machine learning analyses reveals features associated with improved permeation in the pathogen Mycobacterium tuberculosis and model organism M. smegmatis.

go.nature.com

Chris Giuliano of the Birsoy lab has been selected as a 2026 #JCCFellow by @jcchildsfund.bsky.social! Giuliano studies how microbes share and trade nutrients to help reveal novel ways to treat cancer. Congratulations, Chris!

Rockefeller's Winrich Freiwald is a 2026 winner of the Gertrud Reemtsma Foundation’s Prize for Translational Neuroscience! He is honored for his work deciphering complex neural processes in visual perception and social cognition. Congratulations!

Doris Tsao and Winrich Freiwald Receive the International Prize for Translational Neuroscience

Researchers are honored for their groundbreaking insights into the neural basis of face and object recognition

mpg.de

Reminder — UW #Microbiology has an open search for an Assistant Professor, focusing on fundamental problems in #bacteriology! If you or someone you know would be suitable, here's the ad: apply.interfolio.com/185622

The @victora.bsky.social lab at Rockefeller has turned germinal centers into a living laboratory for one of biology's oldest questions: how much of #evolution is shaped by chance? Learn more in this Q&A with Victora and graduate fellow Ashni Vora: https://bit.ly/4fB23bm

A new study from Rockefeller's @victora.bsky.social in @cellpress.bsky.social reveals how germinal centers produce powerful antibodies through noisy rounds of mutation and selection, offering new insight into vaccine design—and larger themes in evolution. 🔗: https://bit.ly/3Sor6Ve

@agnese75.bsky.social's work is out. She shows that under iron starvation M. tuberculosis splits flux through the Krebs cycle and secretes metabolites, akin of fermentation. Why is this important? Metabolic flexibility is what makes it so hard to kill in vivo. elifesciences.org/reviewed-pre...

A new study from the @rocklabtb.bsky.social in @natmicrobiol.nature.com finds that one of the most common drug resistance mutations in #tuberculosis creates subtle metabolic weaknesses that could be exploited with future combination therapies. 🔗: https://bit.ly/3RG6wj2

Happy to share our latest preprint on the clonal dynamics of GC “refueling.” We asked what happens at the clonal level after the simple (and ubiquitous) step of delivering a second vaccine dose during an ongoing GC response. www.biorxiv.org/content/10.6...

Now open - LOIs for the Investigators in the Pathogenesis of Infectious Disease (PATH) program. Deadline is July 16 @ 3pm ET. Faculty in US and Canada are eligible to apply Grant Amount: $505,000 over five years More information here: buff.ly/mBR4XST #bwfpath

Very excited about our recent preprint- @lindashuyingxu.bsky.social and collabs discover that neutrophils repurpose their nucleolus for storage of pre-made IFN-I to be rapidly released via a nucleolar stress response that results in nucleolar extrusion and secretion. www.biorxiv.org/content/10.6...

Honored to have many projects and members of the lab’s research highlighted in the most recent issue of NU magazine @feinberg.northwestern.edu. Check out how folks in our lab are tackling the many challenges associated with Lyme disease! #microsky magazine.northwestern.edu/discovery/ne...

Fighting the Uptick in Lyme Disease

Brandon Jutras, associate professor of microbiology-immunology at the Feinberg School of Medicine, has been studying Borrelia burgdorferi — the bacterium that causes Lyme disease — for over a decade. ...

magazine.northwestern.edu

Huge congrats to @johnrubinstein.bsky.social on being elected a Fellow of the Royal Society! www.sickkids.ca/en/news/arch...

John Rubinstein elected to prestigious Royal Society

SickKids scientist Dr. Rubinstein has been elected a Fellow of the Royal Society for pioneering revolutionary imaging techniques to explore the structure and function of biological molecules.

sickkids.ca

Thrilled to announce that the Department of Microbiology at the University of Washington, School of Medicine is hiring at the Assistant Professor level (tenure-track)! The Pacific Northwest is an awesome place to live and do science 🧪🦠. Join us! apply.interfolio.com/185622 Applications due 8/1.

Very excited this work by Victor and Jakson @crick.ac.uk is out!! started many years ago with @jvaubourgeix.bsky.social They generated Mtb-Timer, a fluorescent reporter in Mtb as a proxy for Mtb replication and measure antibiotic responses Mtbhttps://journals.asm.org/doi/10.1128/msystems.01796-25

Mtb-Timer: a fluorescent reporter to visualize Mycobacterium tuberculosis replication and antibiotic responses | mSystems

Tuberculosis treatment is challenging in part because Mycobacterium tuberculosis (Mtb) populations are phenotypically heterogeneous. Within the same infection, bacterial cells can exist in different physiological states, from actively replicating to slow-growing or non-replicating forms. To better study these processes, we developed and validated Mtb-Timer, a fluorescent reporter that enables visualization of bacterial growth dynamics. The system is based on a fluorescent protein that changes color over time: newly synthesized protein emits green fluorescence (GFP) and gradually shifts to red (DsRed) as it matures. The green-to-red fluorescence ratio, therefore, reflects bacterial replication activity. Using microscopy and flow cytometry in both in vitro cultures and infected macrophages (in cellulo), Mtb-Timer enables the quantification of distinct bacterial subpopulations and the real-time monitoring of the green-to-red fluorescence ratio and bacterial burden during treatment with first-line antibiotics.

journals.asm.org

Transcription attenuation amplifies collateral vulnerabilities in rifampicin-resistant Mycobacterium tuberculosis. Congrats to Kathryn, Vanisha, and all co-authors! www.nature.com/articles/s41...

Transcription attenuation amplifies collateral vulnerabilities in rifampicin-resistant Mycobacterium tuberculosis - Nature Microbiology

A common rifampicin-resistance mutation in Mycobacterium tuberculosis alters transcription and creates new metabolic vulnerabilities through transcription attenuation, revealing potential targets to c...

nature.com

Remembering public health pioneer Barry Bloom: a scientist, a mentor, a mensch. www.statnews.com/2026/03/30/b...

Remembering public health pioneer Barry Bloom: a scientist, a mentor, a mensch

Marc Lipsitch and Yonatan Grad pay tribute to their former colleague and mentor Barry R. Bloom.

statnews.com

Check our new preprint by Knopp M. et al.! Human gut microbiomes can impose strong +/- selection for resistant versions of resident opportunistic pathogens. In the case we follow up, selection is driven by altered carbohydrate utilisation that the resistant mutant evolves. doi.org/10.64898/202...

Congratulations Valerie Mizrahi valmizrahi.bsky.social 🦠 🧪 #WomenInStem #TB www.nasonline.org/news/2026-na...

National Academy of Sciences Elects Members and International Members - NAS

WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 25 international members in recognition of their distinguished and continuing achievements in original res...

nasonline.org

Rockefeller's Vanessa Ruta and Thomas Tuschl have been elected to the @nasonline.org! Congratulations 🎉 🔗: https://bit.ly/4vTZgQ8

Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @nature.com : www.nature.com/articles/s41...

Except in GCs theonion.com/biologists-c...

Biologists Confirm Not Much Evolution Happened Today

STANFORD, CA—Calling it a “pretty slow one” as far as natural selection and genetic drift were concerned, biologists from Stanford University confirmed Tuesday that not much evolution happened today. ...

theonion.com

Discovery of gene functions in #Mycobacterium #tuberculosis has been slow. This study tests a genome-wide barcoded #transposon library across 95 environmental conditions, providing a rich resource of new gene functions, including metabolic & resistance pathways @plosbiology.org 🧪 plos.io/4vG0mz1

By editing blood stem cells, the Nussenzweig lab shows that the immune system itself can be transformed into a durable, boostable source of therapeutic proteins--opening the door to potential single-shot treatments for diseases ranging from HIV to cancer. 🔗: https://bit.ly/4cgDoqp

💥Our latest @embojournal.org on membrane damage and repair. Di @dichen02.bsky.social @crick.ac.uk found that calcium is a conserved signal for ATG8/LC3 lipidation on membranes using novel probes to record calcium leakage. Congratulations Di et al! link.springer.com/article/10.1...

Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair - The EMBO Journal

Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitm...

link.springer.com