A really interesting new two-photon miniscope study for all the retrosplenial geeks out there! Anterior and posterior retrosplenial cortex employ distinct strategies for egocentric–allocentric transformation in spatial coding

***New preprint from the lab*** showing “Generative replay across hippocampal-neocortical circuits”. In sleep we show spiking sequences in V1 (sensory neocortex!) that represent information that has not been directly experienced www.biorxiv.org/content/10.6... @bndu.ox.ac.uk @ndcnoxford.bsky.social

Generative replay across hippocampal-neocortical circuits

To make flexible decisions, the brain needs to make inferences between events that were not directly experienced together. In sharp-wave ripple (SWR) events, during periods of rest and sleep, spiking ...

biorxiv.org

Two-photon calcium imaging. What makes for good data? How can we optimize experiments to get good data? New post labrigger.com/blog/2026/07... and new free web apps from @filip-tomaska.bsky.social (1/8)

🚨 New preprint 🚨 How does the brain learn new things without rebuilding what it already knows? www.biorxiv.org/content/10.6... Fantastic work led by @yuyanghuang.bsky.social and Leonie Mehrke, with Tobias Bernklau and @laurabusse.bsky.social #neuroskyence #neuroscience #learning #PFC 🧪🧠 🧵👇

Excited to finally share our new paper in @natcomms.nature.com: Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval www.nature.com/articles/s41... With @s-michelmann.bsky.social and @doellerlab.bsky.social

Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval - Nature Communications

How past experiences are reconstructed from memory remains unclear. Here the authors used intracranial EEG to show that hippocampal ripples reshape the geometry of cortical representations, supporting...

nature.com

Happy to say our head-direction-cell-in-3D is finally out! doi.org/10.1038/s420... Confirms that the brain's compass uses a dual-axis rule (like an iphone does) to maintain a constant estimate of horizontal heading even when the head is not horizontal. Blogpost explanation here: shorturl.at/9VdGM

Replay of procedural memory is independent of the hippocampus 👀👀 www.nature.com/articles/s41...

Replay of procedural memory is independent of the hippocampus - Nature Neuroscience

Thompson, Rollik and colleagues show that, during sleep, the brain replays procedural memories in the striatum independently of the hippocampus. Replay content was shaped by prior reward and error out...

nature.com

FlatMux: an optimized microscope system for multiplexed 2-photon imaging of neuronal activity with voltage sensors. www.nature.com/articles/s41...

A versatile platform for two-photon neuronal population voltage imaging across cortical depths - Nature Methods

FlatMux is an optimized microscope system for multiplexed two-photon imaging of neuronal activity with genetically encoded voltage sensors. The flexible system is demonstrated in a variety of scenario...

nature.com

1/5 Over a decade of comparing deep neural networks to the human brain—but what have we actually learned? Our new @cp-trendscognsci.bsky.social Feature Review synthesizes a decade of brain–DNN comparisons, asking what they reveal about brain function across vision and language.

cool review on a developmental approach to #NeuroAI Turns out the best benchmark might just be our kids 👶

Vlad Ayzenberg@vayzenb.bsky.social · 2w ago

Excited to share our review in @cp-neuron.bsky.social with @lauriebayet.bsky.social and @mickbonner.bsky.social! We describe how implementing principles from child development can advance the mechanistic plausibility and capacities of AI models We packed A LOT into this review, here's a quick 🧵

Interesting new MEC preprint from Krupic lab

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · last mo.

The medial entorhinal spatial map is built on excitatory-inhibitory network motifs defined by their functional cell type and theta modulation https://www.biorxiv.org/content/10.64898/2026.07.02.735850v1

The medial entorhinal spatial map is built on excitatory-inhibitory network motifs defined by their functional cell type and theta modulation https://www.biorxiv.org/content/10.64898/2026.07.02.735850v1

Anthropic researchers discovered a hidden mental workspace inside Claude called the J-space, where silent reasoning occurs before any output is written. It enables multi-step thinking, self-monitoring and deliberate reasoning! 🧠🤖✨ #AIInterpretability www.anthropic.com/research/glo...

New #Python tool for generating custom channel map configurations (.imro & .json) for #neuropixels recordings. Fixes the tediousness of moving beyond standard single-bank setups in #OpenEphys and #Kilosort. 🔗 github.com/vitalylerner... #ephys #electrophysiology #neuroskyence

GitHub - vitalylerner/imro-neuropixels: Generation of IMRO files for neuropixels probes based on depth range.

Generation of IMRO files for neuropixels probes based on depth range. - vitalylerner/imro-neuropixels

github.com

The emergence of a novel CA1 spatial map requires direct entorhinal input From Kentros Lab. A useful result to help explain how cognitive maps get built www.biorxiv.org/content/10.6...

From a great collaboration with @lorenzoposani.com, @shuqiw.bsky.social, Samuel Muscinelli, Liam Paninski, now in Nature: www.nature.com/articles/s41...

Rarely categorical, highly separable representations along the cortical hierarchy - Nature

Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.

nature.com

A really cool study using waterproof wireless miniscopes in the Morris water maze! NMDA receptor-dependent Hebbian plasticity refines hippocampal spatial representations during two-dimensional navigation learning

NMDA receptor-dependent Hebbian plasticity refines hippocampal spatial representations during two-dimensional navigation learning

Hippocampal place cell activity represents an animal’s location in space; yet, how hippocampal neuronal population dynamics change with spatial learning and the mechanisms underlying these activity ch...

biorxiv.org

Very sad to hear of Susumu’s passing. His scientific creativity and intuition were inspiring. As director of @RIKEN_CBS, he hired a remarkable group of young scientists, including me, and set us free to pursue bold ideas. news.mit.edu/2026/mit-pro...

MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86

Susumu Tonegawa, a renowned MIT professor of biology and neuroscience and a Nobel laureate, has died at the age of 86. His discovery of how the immune system generates many different antibodies earned...

news.mit.edu

Functional Logic of a Cognitive Brain System for Navigation A fascinating review of the Drosophila head-direction system by Gaby Maimon and Larry Abbott #neuroskyence #compneuro

Functional Logic of a Cognitive Brain System for Navigation

It is unusual for cognitive neuroscientists to reach consensus around which computations a brain region implements, what algorithms are used to achieve those computations and how the algorithms are im...

annualreviews.org

How can we generate controllable polar trajectories on neuromorphic hardware? Check out our new pre-print on arXiv to find out all the details, and read the rest of the thread for an overview (1/11): doi.org/10.48550/arX... #neuroAI #CompNeuro #pre-print #neuroskyence #neuromorphic

Just how goal-directed are hippocampal theta sweeps, anyway? Great News & Views from @adredish.bsky.social Lab on recent theta goal papers: www.nature.com/articles/s41... #neuroskyence

Just how goal-directed are hippocampal theta sweeps, anyway? - Nature Neuroscience

Planning is a cognitive process that is thought to be grounded in hippocampal sequences, but recent studies have suggested that a simpler mechanism, fundamentally incompatible with those planning hypo...

nature.com

Our Impact Scholars @neuromatch.bsky.social project on 𝗵𝗼𝘄 𝗿𝗲𝘄𝗮𝗿𝗱 𝘃𝘀 𝗲𝘅𝗽𝗲𝗿𝗶𝗲𝗻𝗰𝗲 𝘀𝗵𝗮𝗽𝗲 𝗻𝗲𝘂𝗿𝗮𝗹 𝗽𝗼𝗽𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝗶𝗻 𝗺𝗼𝘂𝘀𝗲 𝘃𝗶𝘀𝘂𝗮𝗹 𝗰𝗼𝗿𝘁𝗲𝘅 is out! 
 With 𝗝𝗼𝗵𝗻 𝗠𝗮𝗱𝗿𝗶𝗱-𝗖𝗮𝗿𝘃𝗮𝗷𝗮𝗹 @johnmadridcarvajal.bsky.social, 𝗞𝗮𝘁𝗷𝗮 𝗞𝗮𝘂𝗿𝗶𝗻𝗸𝗼𝘀𝗸𝗶, 𝗜𝘀𝗵𝗮𝘁𝗽𝗿𝗲𝗲𝘁 𝗦𝗶𝗻𝗴𝗵, 𝗥𝗼𝗵𝗶𝘁 𝗝𝗲𝘀𝘄𝗮𝗻𝘁𝗵. 🧠 👉 zenodo.org/records/2064... 🧵👇 1/8

📢 #FENS2026 giveaway! We're distributing 8 R2 system starter kits - including one with our new metal holder- for FENS attendees! Apply here: forms.gle/QFnUVZthhcfR...

Ever wondered how the hippocampal cognitive map is read-out? @changmin-yu.bsky.social @zilong-ji.bsky.social with Jake & John, show that, during navigation, theta sweeps indicate remembered goal-directions (cf. current/next movements or perceptual targets) 1/2 www.nature.com/articles/s41...

The human brain is strikingly modular: distinct networks for language, formal reasoning, social reasoning, physical reasoning. Is this fundamental to intelligent systems, or an accident of evolution? In our new preprint, we find the same modular organization emerges in LLMs.

Hippocampal theta sweeps indicate goal direction during navigation www.nature.com/articles/s41...

Hippocampal theta sweeps indicate goal direction during navigation - Nature Neuroscience

Yu et al. show that hippocampal theta sweeps encode goal direction during memory-guided navigation, independent of movement or head direction and correlating with performance, providing a neural subst...

nature.com

In 'How to Change a Memory', Steve Ramirez draws on his own memories of friendship, family, loss and recovery to reveal how memory can be turned on and off like a switch, edited and even constructed from nothing. royalsociety.org/medals-and-p...

The Dead Salmons of AI Interpretability arxiv.org/abs/2512.18792 The famous #fMRI cautionary tale re-born as an analogy for the AI age! @practicalfmri.bsky.social

"From evolution's perspective, we're clearly breaking out of the sandbox." Konrad Kording’s question: If humans escaped evolution’s objectives, should we worry about AI escaping ours? Full conversation with @kordinglab.bsky.social on the @juanbenet.bsky.social Podcast >>> youtu.be/FHQfmJEpRmU