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Albert Gandioso Ubieto

@agandioso.bsky.social

Assistant Professor in Organic Chemistry 🧪🧬 at Universitat de Barcelona @ub.edu and Beatriz Galindo Researcher 🧫💫 @cienciagob.bsky.social

13 Posts924 Follower2898 Folgt
@afranceschem.bsky.social · 8mo ago

The study on the nanomolar phototoxic Ru(II) COUBPY anticancer agents in vivo activated with NIR light is now published in @jacs.acspublications.org Wonderful collaboration with @martaealberto.bsky.social @icmoluv.bsky.social @gassergroup.bsky.social @agandioso.bsky.social doi.org/10.1021/jacs...

π-Extended Ru–COUBPY Photosensitizers for In Vivo Anticancer Phototherapy Using One-Photon 780 nm Near-Infrared Light

Photodynamic therapy (PDT) is a promising cancer treatment modality, offering precise spatial and temporal control of drug activation using light. However, clinical translation of current photosensiti...

doi.org

Albert Gandioso Ubieto@agandioso.bsky.social · 9mo ago

Thrilled to announce that the last two collaborations from my postdoc in the @gassergroup.bsky.social are now published in J. Med. Chem. and JACS. ⚗️🧪 Congrats to all co-authors for the excellent work! pubs.acs.org/doi/10.1021/... pubs.acs.org/doi/abs/10.1...

Inverse Correlation between Endoplasmic Reticulum Stress Intensity and Antitumor Immune Response with Ruthenium(II)-Based Photosensitizers for the Photodynamic Therapy of Head and Neck Squamous Cell Carcinoma

Photodynamic therapy (PDT) is a promising strategy for head and neck squamous cell carcinoma (HNSCC), but the immune consequences of tumor cell death remain incompletely understood. We compared two ruthenium(II) polypyridine photosensitizers (PSs) in HNSCC models and found that both were potently phototoxic (nanomolar IC50s), triggered diverse cell death pathways (including autophagy and ferroptosis), and promoted hallmark danger signals of immunogenic cell death (ICD). Strikingly, only one PS induced apoptosis and strong endoplasmic reticulum (ER) stress, yet paradoxically led to immune tolerance in vivo. Conversely, the PS that did not induce apoptotic cell death with milder stress responses resulted in a better antitumor immunity in vivo. These unexpected findings challenge the prevailing view that PDT-triggered apoptosis and ER stress are essential for ICD. Our study underscores the complexity of PDT-induced cell death balance and immunogenic signals and highlights the need to redefine ICD-inducing criteria for the rational design of next-generation PSs.

pubs.acs.org

@hollensteinlab.bsky.social · 9mo ago

Thrilled to share our article @J_A_C_S on the selection of Ru-modified aptamers. 7 years in the making. Congrats to all authors! Great collaboration with @gassergroup.bsky.social pubs.acs.org/doi/full/10.... @pasteur.fr @ipdbsc.bsky.social @cnrs.fr @pierrenicolasbizat.bsky.social

Selection of Ruthenium Polypyridyl Complex-Modified Aptamers for Photodynamic Therapy against Streptococcus Pneumonia

Photodynamic therapy (PDT) harnesses the combination of light, oxygen, and photosensitizers to induce cell death via reactive oxygen species (ROS) formation. Given its intrinsic properties, PDT repres...

pubs.acs.org

Albert Gandioso Ubieto@agandioso.bsky.social · 9mo ago

⚗️🧪 We are looking for a Postdoctoral Researcher! Join us at Univ. of Barcelona to apply for Juan de la Cierva–Formación 2025 🧬 💡 Light-activated drugs | PDT | Medicinal Chemistry 🎓 PhD obtained in 2024 or 2025 required 📅 Deadline: Nov 20, 2025 📩 vmarchan@ub.edu | agandioso@ub.edu

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@joseruizlab.bsky.social · 9mo ago

Congratulations Gloria! A fantastic Feature Article on Type I photorreactivity in Ir/Ru complexes - great to see in @chemcomm.rsc.org. Kudos to @MarchanLab_UB, & teams led by Brabec, Sastre, @gassergroup.bsky.social, @kargesgroup.bsky.social, Nonell, Frances, @eortegaforte.bsky.social

Gloria Vigueras@viguerasgloria.bsky.social · 9mo ago

Happy to share that our Feature Article has just been accepted in @chemcomm.rsc.org !🎉 We explore Type I photoreactivity in cyclometalated Ir/Ru complexes. Proud to be corresponding author 💡 @joseruizlab.bsky.social @Marchanlab pubs.rsc.org/en/content/art…

CiQUS@ciqus.bsky.social · 10mo ago

🎓 Huge congratulations to Dr. Axel Sarmiento Fuentes on successfully defending his doctoral thesis! 🥂 📘 “Peptide and Supramolecular Engineering for Delivery and Molecular Recognition” Well done, Áxel — we’re proud of you and excited to see where your next chapter leads! #FondosEuropeos

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Albert Gandioso Ubieto@agandioso.bsky.social · last yr.

BioCiudadReal2025 has come to an end! 🧪🇪🇸🧬 A fantastic opportunity to reconnect with the Spanish bioinorganic community. A meeting of outstanding scientific quality, with excellent talks, vibrant discussions, and exciting perspectives for the future. Looking forward to what comes next! ✨ #AEBIN

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CiQUS@ciqus.bsky.social · last yr.

🎖 𝗝𝗼𝘀é 𝗟𝘂𝗶𝘀 𝗠𝗮𝘀𝗰𝗮𝗿𝗲ñ𝗮𝘀, 𝗣𝗿𝗲𝗺𝗶𝗼 𝗥𝗲𝗶 𝗝𝗮𝘂𝗺𝗲 𝗜 2025 𝗲𝗻 𝗜𝗻𝘃𝗲𝘀𝘁𝗶𝗴𝗮𝗰𝗶ó𝗻 𝗕á𝘀𝗶𝗰𝗮 El investigador del CiQUS José Luis Mascareñas ha sido distinguido con uno de los galardones científicos más prestigiosos del país por sus trabajos en 𝗹𝗮 𝗳𝗿𝗼𝗻𝘁𝗲𝗿𝗮 𝗲𝗻𝘁𝗿𝗲 𝗹𝗮 𝗾𝘂í𝗺𝗶𝗰𝗮 𝗼𝗿𝗴𝗮𝗻𝗼𝗺𝗲𝘁á𝗹𝗶𝗰𝗮 𝘆 𝗹𝗮 𝗯𝗶𝗼𝗹𝗼𝗴í𝗮 𝗰𝗲𝗹𝘂𝗹𝗮𝗿.

José Luis Mascareñas, Premio Rei Jaume I en Investigación Básica

El investigador del Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CiQUS) y catedrático de la Universidade de Santiago de Compostela (USC), José Luis Mascareñas Cid,

usc.es

Olalla Vázquez@olallalab.bsky.social · last yr.

Thrilled🤩🤩to share our latest collaboration with #JanSchuller just dropped in Nature!🎉🎉 Huge shoutout to Fidel & all authors; from us 🙌🏿🙌🏿 #FrankAbendroth drived this forward🚀Inspiring science, great vibes & shared vision in #LovelyMarburg 🏰♥️ @synmikro #micros4clima

Fidel Ramírez-Amador@fidelormz.bsky.social · last yr.

I'm truly excited to announce our new publication in @nature.com unraveling a central picture of the Methyl-coenzyme M reductase (MCR) activation machinery and it's strong ATP dependency - kudos to @rnfr2d2.bsky.social for the fantastic illustration! LINK: www.nature.com/articles/s41...

CiQUS@ciqus.bsky.social · last yr.

🎯 Coordinado por José Luis Mascareñas, el equipo del proyecto se centrará en el desarrollo preclínico de un prometedor compuesto químico para hacer frente a las 𝗰é𝗹𝘂𝗹𝗮𝘀 𝗺𝗮𝗱𝗿𝗲 𝗱𝗲 𝗰á𝗻𝗰𝗲𝗿.

Albert Gandioso Ubieto@agandioso.bsky.social · last yr.

🚀 Happy to see our new paper in #NAR @narjournal.bsky.social ! 📜🔬 During my postdoc at @irbbarcelona.org , we systematically studied hybrid triplex topology and stability, suggesting a general triplex-mediated regulatory mechanism. 🧬✨ #TriplexDNA #GeneRegulation academic.oup.com/nar/article/...

Systematic study of hybrid triplex topology and stability suggests a general triplex-mediated regulatory mechanism

Abstract. By combining in silico, biophysical, and in vitro experiments, we decipher the topology, physical, and potential biological properties of hybrid-

academic.oup.com