The choreography of development: RNA localization across time and space Chia-Fang Lee, @flydrbnl.bsky.social & @debbysilver.bsky.social highlight developmental roles for RNA localisation in cell polarity, fate and function across model organisms. journals.biologists.com/dev/article/...

What a fantastic visit I had. Thanks so much @martinowk.bsky.social for hosting me and excited for future collaborations!

Keri Martinowich@martinowk.bsky.social · 2mo ago

Was stoked to host @debbysilver.bsky.social at @lieberinstitute.bsky.social today! Fantastic talk on her lab's work on molecular features that make the human 🧠 unique and how RNA localization shapes early neurodevelopment. Great conversations + exciting ideas for future collaborations - thx Debby!

Delighted to share that our study is now out @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce... Congrats to Dr. @federicamosti.bsky.social for the culmination of a beautiful thesis!

Species-specific chromatin architecture and neurogenesis mediated by a human enhancer

How human-specific DNA changes shape brain development is poorly understood. Mosti et al. discover a human enhancer, HAR1984, which drives ETV5 and TRA2B expression via human-enriched chromatin intera...

cell.com

Debby Silver@debbysilver.bsky.social · 12mo ago

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

There's still time to apply to be a 2026 @dev-journal.bsky.social Pathway to Independence fellow For those about to apply for their first independent academic position, the programme offers - mentoring - leadership training - profile rising - networking journals.biologists.com/dev/pages/pi...

heads up neuro bsky 😎 must-read seminal discoveries: ultimate translation of genetic information in the farthest reaches of the neuron ➡️ @erin-schuman.bsky.social & in cortex development ➡️ @debbysilver.bsky.social thanks again 🤝 @natrevneuro.nature.com Darran Yates for editorial collaboration

Nature Reviews Neuroscience@natrevneuro.nature.com · 9mo ago

The on-site, on-demand, neuronal gene machine — a Journal Club article by Matthew L. Kraushar @matthewkraushar.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...

At Sfn? Join us at the Cajal Club Social! Sunday, Nov. 16th, 6:30PM–8:30PM. Salt & Whiskey bar@Horton Grand Hotel, www.hortongrand.com/dine-bar. We will learn about an exhibition on Cajal's Work and give out this year's awards to outstanding trainees and established scientists in our community!

“Intraspecific sequence variation and complete genomes refine the identification of rapidly evolved regions in humans” New work on HAQERs, by @rimangan.bsky.social Yanting Luo Craig Lowe @debbysilver.bsky.social @manoliskellis.bsky.social & colleagues 🧪🧬 www.biorxiv.org/content/10.1...

Intraspecific sequence variation and complete genomes refine the identification of rapidly evolved regions in humans

Humans exhibit significant phenotypic differences from other great apes, yet pinpointing the underlying genetic changes has been limited by incomplete reference genomes and a reliance on single assemb...

biorxiv.org

I am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...

Thanks @blibep.bsky.social for hosting me in Marseille and sharing your exciting science on cerebellar evolution!! Thanks as well to @alexbaffet.bsky.social and @sbaulac.bsky.social for hosting me in Paris!! What a treat to visit with and discuss fantastic science with all! #internationalscience!

Baptiste Libé-Philippot@blibep.bsky.social · 11mo ago

We were glad to receive @debbysilver.bsky.social 🇺🇸 for a @ibdm.bsky.social keynote lecture "The choreography of brain development: From RNA biology to evolution"! Thank you for coming in Marseille! Very nice chats on neurodevelopment, human evolution, gene regulation! Food and sea also in the menu!

From RNA to evolution: Come join our next keynote lecture on the choreography of brain development by @debbysilver.bsky.social, Professor at Duke University! 📍September 15 at 11am in NQ105 in Martinsried Art by @somedonkey.bsky.social

"What I would simply say is cancer can't wait." --Richard Schlueter, a 56-year-old metastatic cancer patient whose therapy was delayed due to terminations at NIH.

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

Taking a snippet of genetic code that is unique to humans and inserting it into mice helps them grow bigger brains than usual https://go.nature.com/3GOTQkz

Mice grow bigger brains when given this stretch of human DNA

Finding adds to the bigger picture of how humans developed such large brains.

go.nature.com

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature

HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

nature.com

Here is a link to 60 Minutes NIH segment... www.cbsnews.com/news/scienti...

Scientists fear Trump administration cuts to NIH could impact the health of Americans for generations

Former National Institutes of Health Director Dr. Francis Collins, who abruptly left his NIH research lab in February, fears aggressive downsizing could impact Americans' health.

cbsnews.com

Re-amplifying this webinar! #metasci #neuroscience #science This would also be a great opportunity for early-career scientists to learn more about the prize and consider submitting an entry for the NINDS Early-Career Rigor Champions Prize (deadline 5/2/25)! www.challenge.gov?challenge=ni...

Challenge.gov

Challenge.gov is the official government website supporting prize challenges and prize competitions that are sponsored by the US federal government. Here federal agencies provide prize awards to publi...

challenge.gov

Mariah Hoye@mariahhoye.bsky.social · last yr.

April 23rd from 2-3 pm EDT: the NINDS Office of Research Quality will be hosting a webinar featuring the winners of the inaugural NINDS Rigor Champions Prize. Please join us to learn more about the winners and their efforts to promote research rigor and transparency! REGISTER HERE: bit.ly/42kBZZU

"This will go down as one of the darkest days in modern scientific history." Story on the decimation of NIH by @maxkozlov.bsky.social www.nature.com/articles/d41...?

‘One of the darkest days’: NIH purges agency leadership amid mass layoffs

In shock move, four institute directors at the US biomedical agency are removed from their posts.

nature.com

Trump has cut the NIH budget by more than half in defiance of Congressionally mandated appropriations for the agency. No comparison historically, not even the Great Recession. This is clearly not legal and Congress needs to address it.

Inspiring speakers highlighting the importance to our collective health as well as economic return on investment of basic, curiosity-driven research at yesterday’s @standupforscience.bsky.social Frightening to see active dismantling of decades of public investments in our health and futures.

New story on NIH intramural research issues. www.science.org/content/arti...

NIH ban on renewing senior scientists adds to assaults on its in-house research

Policy follows firings of tenure-track scientists and suspension of training programs

science.org

I have been talking to the media, Time, Fortune, NBC, etc., to explain how the onslaught on science and NIH will impact the health of all Americans. Everyone knows someone who has cancer, heart disease, or depression. Spread the word about how cutting science impacts all. time.com/7216299/nih-...

Experts Call NIH Budget Cuts an 'Apocalypse' for Science

The reductions target indirect costs that cover administrative and equipment costs.

time.com

Don’t lose hope. Remember, Watergate took over two years to fully unravel from the initial break-in to Nixon’s resignation. Just like then and now, Americans are losing faith in their government. We are documenting every illegal action and will hold this administration and Elon Musk accountable.

Our values and resolve are only strengthened by recent events.

Trump & Musk are making massive cuts to the National Institutes of Health. I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.

To my friends and colleagues at UAB, IU, UF, FSU, UL, WashU, OSU, CWRU, etc, etc. Call both your senators and your representative. They listen. Emphasize the direct economic impact of NIH research, and the indirect impacts on pharmaceutical/biotech. Underscore its relevance to national security.

Adrianna McIntyre@adrianna.bsky.social · last yr.

The Senate HELP Committee has jurisdiction over NIH. GOP members of the committee represent AK, AL, IN, FL, KS, KY, LA, ME, MO, OH, and SC. Research universities and hospitals in those states need to be extra loud.

OMB memo tonight “Temporary Pause of Agency Grant, Loan, and Other Financial Assistance”

I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service. “Pausing” grants means people don’t eat.

White House pauses all federal grants, sparking confusion

The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.

washingtonpost.com

I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏 www.nytimes.com/2024/12/09/h...