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Andy Cooper

@aicooper.bsky.social

Mostly science related. Occasional gardening to be feared. "Aren't you the guy who built that robot?"

592 Posts2666 Follower826 Folgt
Andy Cooper@aicooper.bsky.social · 3w ago

Not clear how the already overstretched publishing industry will respond to this trend. Perhaps it will ultimately kill off the review article and people will make personal, bespoke reviews to order? But in energy terms, that’s like re-building your car every time you want to go for a drive …

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Andy Cooper@aicooper.bsky.social · 3mo ago

I could swear I've seen the methylated HOF material reported in this paper somewhere before ... pubs.acs.org/doi/10.1021/...

Strategic MOF Linker Methylation to Direct Pore Structure and Local Dynamics

The marvelous substrate recognition of enzyme hosts is attributed to induced-fit binding, in which the enzyme host maintains a delicate balance between preorganization and flexibility. For synthetic porous hosts such as MOFs, programmable control over the local and global flexibility modes is thus crucial for the optimization of host–guest interactions. Here we show that methylation adjacent to the pyrene-arene junction of the linker permits the synthesis of a derivative of NU-1000 in which aryl rotation is thermally inaccessible, but small-angle librations remain facile. Mechanochemically promoted Suzuki cross-coupling was able to overcome the twin challenges of poor solubility and steric congestion to access a linker that could not be prepared in solution. The incorporation of methyl groups in the linker controls the local dynamics of the MOF pore and permits a window that interconnects channels in the unsubstituted MOF to evolve into a separate micropore environment. In addition, we show how the different chemical shifts observed for nuclei that extend into distinct MOF pores permit experimental determination of rotational barriers via variable-temperature 13C solid-state NMR.

pubs.acs.org

Andy Cooper@aicooper.bsky.social · 3mo ago

“… as their careers progress, scientists are more likely to cite older papers than newer ones. This phenomenon, which the authors call the nostalgia effect, can hold back scientific innovation”

Nature@nature.com · 3mo ago

Experienced researchers are less likely to produce ‘disruptive’ science than are those just starting their careers, finds an analysis of the scientific papers published by 12.5 million researchers over 60 years. go.nature.com/4uUvMk3

Andy Cooper@aicooper.bsky.social · 3mo ago

O Thou who passest thro’ our vallies in Thy strength, curb thy fierce steeds, allay the heat That flames from their large nostrils! thou, O Summer, Oft pitched’st here thy golden tent, and oft Beneath our oaks hast slept, while we beheld With joy, thy ruddy limbs and flourishing hair.

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