Secure your discounted ticket for the Reproductive Endocrinology Meeting before Friday at 23:59! Find out more: bit.ly/ReproEndo26
akheel sͩyͬed
@akheelsyed.bsky.social
Consultant Endocrinologist and Professor Salford Royal, Manchester Academic Health Science Centre, University of Manchester
Come join a dynamic bariatric and upper GI surgery service in Greater Manchester 🙌 www.healthjobsuk.com/job/UK/Manch...
Job vacancy: Consultant Bariatric & Benign Upper GI Surgeon, Northern Care Alliance NHS Foundation Trust, Salford | trac.jobs
healthjobsuk.com
Excessive weight gain following treatment for hyperthyroidism is of concern to patients and clinicians. More needs to be done to understand its implications and the best strategies of management.
Nature Reviews Endocrinology@natrevendo.nature.com · 2mo agoNew content online: Post-thyrotoxicosis weight gain: time to stratify and treat?
Arginine vasopressin disorders: Diabetes insipidus has been renamed to arginine vasopressin disorders for clarity and safety. ➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251716
Preventing and Managing Adrenal Crisis – your experience matters. 📢 People living with, or affected by, adrenal insufficiency, including Addison’s, are the experts in their own rare condition. Your personal story is the most powerful tool for driving change. Take part ➡️ loom.ly/YaPyAug
Incretin/GLP-1 users include many women of childbearing age. We discuss if this can have consequences for pregnancy outcomes. @ncaresearchnhs.bsky.social pubmed.ncbi.nlm.nih.gov/42017293/
The Risk of GLP-1 Receptor Agonist (GLP-1 RA) Exposure in Early Pregnancy. A Call to Action: Quantifying the Impact on Pregnancy Outcomes in the United Kingdom - PubMed
The Risk of GLP-1 Receptor Agonist (GLP-1 RA) Exposure in Early Pregnancy. A Call to Action: Quantifying the Impact on Pregnancy Outcomes in the United Kingdom
pubmed.ncbi.nlm.nih.gov
Acromegaly | New England Journal of Medicine www.nejm.org/doi/full/10.... @safwaanadam.bsky.social and Syed. We propose a role for incretin therapies in the management of coexisting conditions such as obesity, obstructive sleep apnea, and diabetes.. @ncaresearchnhs.bsky.social @manchester.ac.uk
Acromegaly | NEJM
To the Editor: In their review article, Giustina and Colao (November 13 issue)1 discuss acromegaly and its craniofacial manifestations. Dentists and oral and maxillofacial surgeons are often among ...
nejm.org
In The #Endocrinologist, @safwaanadam.bsky.social and @akheelsyed.bsky.social, describe the various biological effects of obesity in worsening the health of the heart muscle and blood vessels, and how weight loss treatments have benefits for cardiovascular health too. 🫀 Read more👉 shorturl.at/KML5v
Thyroid overactivity worsens patients' quality of life (QoL). After treatment, QoL is not completely restored for many patients. We discuss reasons, and new approaches to address long-term effects on QoL. @ncaresearchnhs.bsky.social @endoconnect.bsky.social www.researchgate.net/publication/...
Prioritizing Quality of Life in the management of hyperthyroidism—An expert clinical perspective | Request PDF
Request PDF | Prioritizing Quality of Life in the management of hyperthyroidism—An expert clinical perspective | Hyperthyroidism adversely affects quality of life (QoL), encompassing physical, mental ...
researchgate.net
What's the diagnosis? Be warned: Not everything is as it seems! Ali, @adhithyasankar.bsky.social, et al. @ncaresearchnhs.bsky.social www.ccjm.org/content/93/1...
A young woman with Kallmann syndrome and acute neurologic symptoms
Diagnoses considered on initial presentation included conditions that present with stroke-like symptoms such as seizure, hemiplegic migraine, transient ischemic attack, and brain tumor.
ccjm.org
Women under 45 are at increased risk of vitamin D and calcium deficiencies after bariatric surgery. @ncaresearchnhs.bsky.social rdcu.be/eYuiy
Client Challenge
rdcu.be
Weight gain after treatment of hyperthyroidism is associated with a large adverse effect on quality of life. Angelos Kyriacou et al. @ncaresearchnhs.bsky.social pubmed.ncbi.nlm.nih.gov/41448910/
Weight Gain after Treatment of Hyperthyroidism is Associated with Impairment of Quality of Life - PubMed
<span><b><i>Background:</i></b> There is evidence of quality of life (QoL) impairment and weight gain in treated hyperthyroidism. It is not known whether treatment-related weight gain is associated with QoL impairment in this patient group of this cohort. Our primary aim was to examine whether percentage</span> …
pubmed.ncbi.nlm.nih.gov
Recognising obesity as a primary driver of CVD reinforces the need for early, proactive intervention. @safwaanadam.bsky.social @socendocrinology.bsky.social @ncaresearchnhs.bsky.social www.endocrinology.org/endocrinolog...
OBESITY AND CARDIOVASCULAR DISEASE: CORE RELATIONSHIPS AND MANAGEMENT OPTIONS | Society for Endocrinology
The Society for Endocrinology aims to promote the advancement of public education in endocrinology
endocrinology.org
Thymic hyperplasia: Thymic hyperplasia, common in children and adolescents, is unusual in adults owing to age-related involution. ➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250929
Thymic hyperplasia in an adult with Graves disease
A 47-year-old man with discomfort in the upper chest, difficulty swallowing food and drinks, and weight loss of 10 kg over 2 months underwent computed tomography (CT), which excluded malignancy but sh...
cmaj.ca
Jack Roddy, Shaishav Dhage and Akheel Syed. @ncaresearchnhs.bsky.social Treat the Graves' hyperthyroidism and the thymic hyperplasia resolves. www.cmaj.ca/content/197/...
Thymic hyperplasia in an adult with Graves disease
A 47-year-old man with discomfort in the upper chest, difficulty swallowing food and drinks, and weight loss of 10 kg over 2 months underwent computed tomography (CT), which excluded malignancy but sh...
cmaj.ca
Long-term outcomes of Roux-en-Y gastric bypass in the adolescent population: a systematic review and single-arm meta-analysis - Surgery for Obesity and Related Diseases www.soard.org/article/S155...
Long-term outcomes of Roux-en-Y gastric bypass in the adolescent population: a systematic review and single-arm meta-analysis
Long-term outcomes of Roux-en-Y gastric bypass (RYGB) in adolescents are limited. This systematic review and meta-analysis evaluates the safety and efficacy of RYGB in adolescents with obesity. A comp...
soard.org
Time for wider adoption of salivary cortisone in endocrinology? @akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone jamanetwork.com/journals/jam...
Adult Adrenal Insufficiency
To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...
jamanetwork.com
Adult Adrenal Insufficiency url: jamanetwork.com/journals/jam... The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults
Adult Adrenal Insufficiency
To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...
jamanetwork.com
More than 2 decades since GLP-1 drugs were introduced, we still don't know why people with diabetes lose about half as much weight as those without diabetes at the same dose nature.com/articles/s41...
Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis - International Journal of Obesity
International Journal of Obesity - Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis
nature.com
Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss www.nejm.org/doi/full/10....
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | NEJM
Orforglipron, a small-molecule, nonpeptide oral glucagon-like peptide-1 (GLP-1) receptor agonist, is being investigated as a treatment for obesity. In this phase 3, multinational, randomized, doubl...
nejm.org
Obesity and Metabolic Syndrome: Current Insights and Future Directions. Zaiem Zarkasi, Rajshekhar N. Mudaliar, Waseem A. Majeed, and Akheel A. Syed. British Journal of Hospital Medicine www.magonlinelibrary.com/doi/full/10....
Obesity and Metabolic Syndrome: Current Insights and Future Directions | British Journal of Hospital Medicine
Obesity and metabolic syndrome are global health challenges, significantly increasing risks for type 2 diabetes, cardiovascular and cerebrovascular diseases, and overall mortality. This narrative revi...
magonlinelibrary.com
“With only one other drug, resmetirom, specifically approved for the treatment of MASH, the new approval of semaglutide, a drug from a well known and widely used class of medications for type 2 diabetes and obesity, is most welcome.” www.bmj.com/content/390/...
Semaglutide: FDA approves weight loss jab to treat severe liver disease
The US Food and Drug Administration has approved the weight loss drug semaglutide, marketed as Wegovy, for the treatment of patients with a severe form of liver disease called metabolic associated ste...
bmj.com
Type 2 diabetes: SGLT-2 inhibitors to be offered as first line treatment in major guidance “shake-up” www.bmj.com/content/390/...
Type 2 diabetes: SGLT-2 inhibitors to be offered as first line treatment in major guidance “shake-up”
Doctors could soon be offering sodium-glucose cotransporter-2 (SGLT-2) inhibitors as a first line treatment option for all patients with diabetes, not just those with heart disease.1 The change has b...
bmj.com
Incretin-based therapies delay gastric emptying and therefore may reduce the absorption of any oral component of HRT. @annicemukherjeemd.bsky.social et al. pubmed.ncbi.nlm.nih.gov/40378270/
Use of incretin-based therapies in women using hormone replacement therapy (HRT) - PubMed
Use of incretin-based therapies in women using hormone replacement therapy (HRT)
pubmed.ncbi.nlm.nih.gov
In this study, more than half the patients with hyperthyroidism had ≥10% peak weight gain after treatment. We need to acknowledge, recognise and manage this issue better. pubmed.ncbi.nlm.nih.gov/40238086/
Severity of thyrotoxicosis is a risk factor for excessive weight gain in treated hyperthyroidism - PubMed
More than half the patients with hyperthyroidism had ≥10% PWG post-treatment. Indicators of disease severity, namely disease-related weight loss and baseline thyroid hormones, were predictive of exces...
pubmed.ncbi.nlm.nih.gov
annicemukherjeemd.bsky.social et al discuss considerations when prescribing incretin-based therapies in women using HRT during the menopause transition and postmenopause; and thebms.org.uk/2025/04/new-...
NEW BMS Tool for Clinicians – Use of incretin-based therapies in women using HRT
NEW BMS Tool for Clinicians – Use of incretin-based therapies in women using HRT
thebms.org.uk
Aisha Awan and colleagues argue for nationally funded training programmes for the integration of displaced refugee and asylum seeking healthcare professionals @bmj.com www.bmj.com/content/388/...
Training refugee and asylum seeking healthcare professionals: an ethical approach to UK workforce challenges
Aisha Awan and colleagues argue for nationally funded training programmes for the integration of displaced refugee and asylum seeking healthcare professionals Wars in Gaza, Lebanon, Sudan, Syria, Ukr...
bmj.com
A new way to measure your food intake, from your 💩 www.nature.com/articles/s42... www.nature.com/articles/s42... "proof-of-concept for detailed tracking of individual-specific, health-relevant dietary patterns without the need for questionnaires."
Querying stool for dietary information - Nature Metabolism
Accurately determining food intake remains a substantial challenge in nutrition research. This issue of Nature Metabolism introduces a methodology for assessing dietary intake, using stool metagenomic...
nature.com
Thanks for sharing 🙏🏻 This review is open access and aimed at all health professionals involved in menopause care
akheel sͩyͬed@akheelsyed.bsky.social · last yr.Very comprehensive review by two top experts in the field. onlinelibrary.wiley.com/doi/10.1111/...
Very comprehensive review by two top experts in the field. onlinelibrary.wiley.com/doi/10.1111/...
Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions
Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing p...
onlinelibrary.wiley.com