Adhithya Sankar
@adhithyasankar.bsky.social
Endocrinologist. Salford Royal Hospital, UK. Previously @UoM. Dad, hiker and nature lover 🏞️
In The #Endocrinologist, @safwaanadam.bsky.social and @akheelsyed.bsky.social, describe the various biological effects of obesity in worsening the health of the heart muscle and blood vessels, and how weight loss treatments have benefits for cardiovascular health too. 🫀 Read more👉 shorturl.at/KML5v
Thyroid overactivity worsens patients' quality of life (QoL). After treatment, QoL is not completely restored for many patients. We discuss reasons, and new approaches to address long-term effects on QoL. @ncaresearchnhs.bsky.social @endoconnect.bsky.social www.researchgate.net/publication/...
Prioritizing Quality of Life in the management of hyperthyroidism—An expert clinical perspective | Request PDF
Request PDF | Prioritizing Quality of Life in the management of hyperthyroidism—An expert clinical perspective | Hyperthyroidism adversely affects quality of life (QoL), encompassing physical, mental ...
researchgate.net
What's the diagnosis? Be warned: Not everything is as it seems! Ali, @adhithyasankar.bsky.social, et al. @ncaresearchnhs.bsky.social www.ccjm.org/content/93/1...
A young woman with Kallmann syndrome and acute neurologic symptoms
Diagnoses considered on initial presentation included conditions that present with stroke-like symptoms such as seizure, hemiplegic migraine, transient ischemic attack, and brain tumor.
ccjm.org
Time for wider adoption of salivary cortisone in endocrinology? @akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone jamanetwork.com/journals/jam...
Adult Adrenal Insufficiency
To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...
jamanetwork.com
Adult Adrenal Insufficiency url: jamanetwork.com/journals/jam... The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults
Adult Adrenal Insufficiency
To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...
jamanetwork.com
Does every person with type 2 diabetes respond the same way to GLP-1 receptor agonists? Recent clinical data suggest otherwise. #GLP1 #diabetes link.springer.com/article/10.1... 🔓
Heterogeneity in response to GLP-1 receptor agonists in type 2 diabetes in real-world clinical practice: insights from the DPV register – an IMI-SOPHIA study - Diabetologia
Aims/hypothesis Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a cornerstone in type 2 diabetes management. In this study we evaluated heterogeneity in body weight and glycaemic responses t...
link.springer.com
#Adrenocortical #carcinoma is a rare malignancy, in contrast to benign #adrenal tumours, which are among the most common human neoplasias with a prevalence of greater than 3% in adults older than 50 years www.thelancet.com/journals/lan... #OpenAccess #MedSky #EndoSky #OncSky
Adrenocortical carcinoma: a practical guide for clinicians
Adrenocortical carcinoma is a rare endocrine malignancy. The management of patients with adrenocortical carcinoma is challenging for several reasons, including its heterogeneous but frequently aggress...
thelancet.com
www.nature.com/articles/s41...
GLP-1 receptor agonists causing euglycemic ketoacidosis in patients without diabetes: a brief review - International Journal of Obesity
International Journal of Obesity - GLP-1 receptor agonists causing euglycemic ketoacidosis in patients without diabetes: a brief review
nature.com
How to think about evaluation of low testosterone levels, SHBG, clinical symptoms and possible benefits vs. real risks of treatment in the context of #obesity academic.oup.com/jcem/advance...
Approach to the patient: Low testosterone concentrations in men with obesity
Abstract. Pathologic hypogonadism occurs when serum testosterone is significantly and persistently reduced by irreversible organic (structural, genetic) di
academic.oup.com
#Finerenone: CV & renal protection across all #T2D therapies❗️ 🔹 Pooled analysis: 15,365 pts w/ T2D + CKD or CV 🔸 Consistent benefit on 💔☠️, 🏥💔& kidney outcomes 🔹 ⤴️K+ ⤵️ with SGLT2i use 🔸 Benefit independent of SGLT2i/GLP-1 use 👉 Supports finerenone as a 🎯 in high-risk #T2D❗️ 🔗 ggdocs.co/tx2a5r
academic.oup.com/ejendo/advan...
Delphi Panel consensus on recommendations for thromboprophylaxis of venous thromboembolism in endogenous Cushing's syndrome: a Position Statement
AbstractObjective. To establish recommendations for thromboprophylaxis in patients with endogenous Cushing's syndrome (CS), addressing the elevated risk of
academic.oup.com
Pleased to share our case report! RAI is known to worsen TED in Graves’ disease, but what about nodular thyroid disease? Assessment of TPO antibody, and not just TRAb prior to RAI may be informative in guiding decision-making around steroid prophylaxis. casereports.bmj.com/content/18/2...
De novo Graves’ thyroid eye disease after radioiodine treatment for toxic nodular thyroid disease
It is well known that radioactive iodine treatment (RAI) for thyrotoxicosis in Graves’ disease can precipitate worsening of thyroid eye disease (TED), particularly in susceptible patients. Less common...
casereports.bmj.com
Obesity is the third most important predictor of heart disease. We discuss pathophysiology and management including roles of anti-obesity medications and bariatric surgery. @ncaresearchnhs.bsky.social www.sciencedirect.com/science/arti...
Obesity Management for Patients with Coronary Artery Disease and Heart Failure
sciencedirect.com
Accurate prediction of long-term postoperative weight loss is important for advising patients undergoing bariatric surgery. @adhithyasankar.bsky.social et al. pubmed.ncbi.nlm.nih.gov/39887840/ @ncaresearchnhs.bsky.social
Actual weight loss trajectories after bariatric surgery compared with the SOPHIA prediction tool: An observational comparison study - PubMed
The SOPHIA study tool provides accurate postoperative weight forecasts for some subgroups of patients, but its precision diminishes with time. This study reiterates the necessity for better personaliz...
pubmed.ncbi.nlm.nih.gov
How well can we predict weight loss after bariatric surgery? Our study assessed the SOPHIA weight prediction tool in our patient population. dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
Peri-operative management of GLP-1 RAs & SGLT2 inhibitors❗️ 🔹 New 🇬🇧 consensus: GLP-1 RAs can continue, but risks of aspiration must be assessed. 🔸SGLT2i should be stopped 1 day pre-op to avoid euglycemic DKA. ❗️shared decision-making & tailored approaches to optimise safety. 🔗 ggdocs.co/4r995z
🧵 Cancer Cachexia and the Brain Stem (a thread) In NEJM, Groarke et al. report the results of a phase 2 clinical trial of ponsegromab therapy for cancer cachexia in patients with elevated humoral levels of growth differentiation factor 15 (GDF-15). nej.md/3XE645a 1/10 #MedSky #ScienceSky
Eye-opening patient story regarding ACC and mitotane
Vin Tangpricha, MD, PhD@vtangpricha.bsky.social · 2y agoA physician’s personal story of his battle vs Adrenal Cancer published in #EndocrinePractice via Adrenocortical Carcinoma and the Mitotane Morass: A Physician/Patient Perspective #endosky www.endocrinepractice.org/article/S153...
It’s a big day for @genesandhealth.bsky.social @samcbhodgson.bsky.social @moneeza-ks.bsky.social Genes & Health, with @ Sam Hodgson, Moneeza Kalhan Siddiqui and I, as we publish our paper rdcu.be/d1vj0 on the genetic basis of #type2diabetes & #gestationaldiabetes (#T2D and #GDM) in south Asians. A🧵
Genetic basis of early onset and progression of type 2 diabetes in South Asians
Nature Medicine - In a cohort of 50,556 South Asian individuals, partitioned polygenic scores helped identify genetic susceptibility to insulin deficiency and unfavorable fat distribution as key...
rdcu.be
Presentation and management of patients with adrenal masses: a large tertiary centre experience by Onnicha Suntornlohanakul et al @Bham_AT doi.org/10.1093/ejen... #adrenal #phaeochromocytoma #ACC
Presentation and management of patients with adrenal masses: a large tertiary centre experience
AbstractBackground. Adrenal masses are found in up to 5%-7% of adults. The 2016 European guidelines on the management of adrenal incidentalomas have standa
doi.org
How the #brain talks to the #gut and vice versa! 🧪🧠💩 Check out the great primer on gut-brain communication and #interoception by @amberalhadeff.bsky.social and Nilay Yapici 👇👇👇 www.cell.com/current-biol...
Honey, stop what you're doing, new hyponatremia research just dropped! What's it say? It looks like slow correction is associated with worse outcomes, like death and length of stay! Was it just a small study? No, it was a meta-analysis of almost 12,000 patients! jamanetwork.com/journals/jam...
Correction Rates and Clinical Outcomes in Hospitalized Adults With Severe Hyponatremia
This systematic review and meta-analysis evaluates the association of sodium correction rates with mortality among hospitalized adults with severe hyponatremia.
jamanetwork.com
Expert statement on Diagnosis & Mx of peripheral neuropathy in #diabetes & pre-diabetes (Gulf region) 🔸suggest routine screening (patient questionnaire & clinical assessment) 🔹Universal B12 Rx 🔸Check B 1&6 levels 🔹Use of CGM 🔸Use of GLP1 🔗 link.springer.com/article/10.1...
