Alex Lippert

@alexlippert.bsky.social

Professor of Chemistry at Southern Methodist University. Chemiluminescence and Molecular Machines.

I wrote about a reason not to use generative AI in your writing that I haven't seen anyone talking about. Once I realized this, banning GenAI in our lab's writing became a no-brainer. Feel free to share, I think this is probably useful especially for trainees: www.carlsonlab.bio/thoughts/the...

The only reason you’ll ever need not to write with AI — The Carlson Lab

Over the last year, our lab has been developing a policy on AI use. To do this, we did three main things: We read a lot of academic publications and tech news. We set up an #ai channel on our la...

carlsonlab.bio

US scientists: Going into fall 26, how are you thinking about things? Following Fall 24 events and a tumultuous spring 25, I remember a convo with a colleague in which we agreed we just needed to wait things out until fall 25 and we'd have some clarity about the landscape (eg for funding). /1

Hi, this is Holden emerging from my Bluesky hiatus to tell everyone that when checking the links in the piece, I used ChatGPT as my search engine (does anyone use Google anymore?). The piece was written by me and edited by humans. So all the links were checked by me and again by our copyeditors.

📢 Hiring a postdoc! Join my group on an NIH-funded project developing hydrazone-based photoswitchable fluorophores for super-resolution microscopy. Looking for expertise in organic synthesis, photochemistry, spectroscopy, systems/supramolecular chemistry, and/or chemical biology. #chemjobs #chemsky

Latest @jacs.acspublications.org a collab with Mastalerz grp @uniheidelberg.bsky.social showing how C3-symmetric TBTQ core affects chiral induction in LCs. Hydrazone > azobenzene with this core. Mixing these two with opposite chirality allows handedness inversion bit.ly/4qAtvYE #openaccess #chemsky

C3-Symmetric Photoresponsive Chiral Dopants Based on Tribenzotriquinacene

Doping cholesteric liquid crystals (CLCs) with photoresponsive chiral molecules is an effective strategy for devising responsive soft materials, as it allows for the phototuning of the noncovalent interactions in the CLCs, and hence, their helical pitch and optical properties. Here we describe the use of tribenzotriquinacene-based (TBTQ) hydrazone and azobenzene chiral dopants in the modulation of the helical pitch of the LC host, 5CB. The unique C3-symmetry of the TBTQ scaffold enhances the noncovalent interactions with the host and thus the chiral information transfer, resulting in helical twisting power (β) values as high as 147 μm–1. Notably, the TBTQ hydrazone exhibits an unusual deviation from trends observed so far in previous studies, resulting in larger β values for the Z isomer rather than the E one. Moreover, the overall β values for the hydrazone-based dopants are unexpectedly higher than those of the azobenzene dopants. These results indicate that the host/guest interactions are better when the photoswitchable chiral dopant is more rigid, as is the case with the H-bonded Z state of the hydrazone. The large β values and excellent miscibility of the hydrazone-based dopants in 5CB allowed us to design films that reflect visible structural color. The properties of the azobenzene-based dopants precluded their use in such applications. By codoping 5CB with hydrazone and azobenzene derivatives of opposite chirality, we demonstrated reversible handedness inversion upon photoswitching, providing a versatile soft material platform for reconfigurable photonic materials and colorimetric display technologies.

bit.ly

Over the past century, quantum mechanics has served as the foundation for modern physics theories, including quantum field theory. The theoretical groundwork is now being transformed into new disciplines. Learn more in a new special issue of Science: https://scim.ag/4oz1y2a

The Schrödinger equation, together with the associated wave function often denoted by the Greek letter Ψ, is at the core of quantum mechanics. Over the past century, quantum mechanics has served as the foundation for modern physics theories, including quantum field theory. The theoretical groundwork is now being transformed into new disciplines, such as quantum information science and technology, and quantum materials.

After the Royal Society meeting on the future of quantum computing at the start of the year, I took a deep dive for @physicsworld.bsky.social into the state of the industry. The piece sat for a long time in the pipeline, but here now is the first part. physicsworld.com/a/quantum-co...

Quantum computing on the verge: a look at the quantum marketplace of today – Physics World

Philip Ball dives into the latest developments in the quantum-computing industry

physicsworld.com

In this piece for Aeon, I argue that, while nanotechnology is now a very real and mature field, a popular early vision of it was an example of what I am calling an "oneiric technology": a fantasy of the sort that Silicon Valley loves. aeon.co/essays/no-su...

No suffering, no death, no limits: the nanobots pipe dream | Aeon Essays

Thirty years ago, nanotech was about to change everything. Let’s not get tricked again by Silicon Valley’s magical thinking

aeon.co

This week in Science, researchers report an artificial molecular motor that can twist a molecular thread to form a mechanically interlocked molecule. The approach creates opportunities to fabricate mechanically interlocked molecules with precise structural control. Learn more: scim.ag/40FboGP

This illustration shows consecutive stages during operation of a molecular catenating machine.