One of the many things I love about @ascbiology.bsky.social ,my favorite scientific society, is that it recognizes there are many ways to contribute to science, including mentoring, education, outreach and advocacy. This year's Fellows represent that. 1/n www.ascb.org/society-news...

Happy Fourth of July. A reminder that democracy, like science, depends on care, integrity, and collective responsibility. Let us all do our part

Truer words were never spoken. Really important session on cancer prevention and screening with a focus on policies #AACR26

First AACR Meeting ever as a non-UCLA affiliate, big changes and so excited for what’s ahead. If you see me around, stop to say hi 👋 #AACR 26

Artemis astronauts now sharing photos of the moon they have taken with their iPhones. The lights are switched off on the spaceship so they can take photos better.

Just learned the Artemis II team is getting a better lunch than I am. Well then.. www.youtube.com/watch?v=m3kR...

NASA's Artemis II Live Mission Coverage (Official Broadcast)

YouTube video by NASA

youtube.com

Cancer research, dismantled. Only *35* grants awarded so far in FY26. NCI stats for new and competitive grant renewals from: grant-witness.us/funding_curv...

There is barely any money going out the door as is

Joshua Weitz@joshuasweitz.bsky.social · 4mo ago

A 20% budget cut atop multiyear funding-induced cuts to research and direct terminations of projects underway will further degrade American leadership in science. This is early news & not even a proposal or appropriations - precisely the reason to speak out now. rollcall.com/2026/03/27/s...

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.

Sequence and chemical specificity define the functional landscape of intrinsically disordered regions - Nature Cell Biology

Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...

nature.com

Alex Holehouse@alexholehouse.bsky.social · 2y ago

We’re pleased to share our substantially updated (more below on that…) version of our manuscript exploring the relationship between conservation in sequence/function for intrinsically disordered regions (IDRs) www.biorxiv.org/content/10.1...

We're hiring villagers! We are looking for a lab technician to help us discover how gene-by-environment interactions shape the developing brain via in vitro cell villages. Please DM me or visit our website at mfwellslab dot com for more info. Deadline to apply is March 11th: tinyurl.com/34seyjaj

Laboratory Assistant II - Human Genetics - UCLA Health Careers - Job #29031 - Los Angeles, CA

Take a look at a great career opportunity where you can make a real difference at UCLA Health

uclahealthcareers.org

On the side of small gripes: I'll never find reasonable to be asked to be online at 5am to review grants especially now that paylines are gone-and so are grants. It's unreasonably burdensome for all, even more so for those getting children ready for/to school. If the goal is inclusion, 5am is not it

That's right. Worse than Pointless www.nytimes.com/2026/02/23/o...

This is a graph of the death of US science.

Jeremy Berg@jeremymberg.bsky.social · 5mo ago

NSF Update (Awards through 2/27/26) Directorates to follow 1/10

It's a tragedy. I hope no one thinks that we are over the hump. This is quite literally how federally supported science goes extinct.

Max Kozlov@maxkozlov.bsky.social · 5mo ago

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers. The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers. The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

White House stalls release of approved US science budgets

The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

nature.com

Finally, today's offering! www.biorxiv.org/content/10.6... This began life as a very different project which failed because we couldn't agree on defining eqtl sharing across cohorts. So two young members of the lab dug deeply into this - first @ijbeasley.bsky.social, then @patrickgibbs.bsky.social

New version of our preprint on bioRxiv about bioRxiv up. Now that’s what I call a revision – 6 years after the first version! It has new data about our progress and highlights from a massive user survey. 1/n www.biorxiv.org/content/10.1...

A nationally recognized leader in patient-derived tumor organoids and functional precision oncology has arrived at CU! Welcome, Alice Soragni, PhD (@alice.soragnilab.com) 👋 ⬇️ https://news.cuanschutz.edu/dbmi/alice-soragni-joins-university-colorado-anschutz

CU Anschutz Recruits National Leader to Launch Functional Personalized Medicine Initiative

National leader in tumor organoids Alice Soragni, PhD, launches a rapid functional precision medicine initiative at CU Anschutz within CCPM and DBMI.

news.cuanschutz.edu

This is an interesting article for those beginning down the cryoEM route for structure determination from the perspective of a crystallography lab. Not giving up on crystallography yet 😜 but I honestly can't think of a single crystallography lab now that isn't also using CryoEM in some capacity.

Structural Biology@actacrystd.iucr.org · 6mo ago

Hassan Zafar et al.: Breaking barriers: transitioning from X-ray crystallography to cryo-EM for structural studies #CryoElectronMicroscopyCryoEM #StructuralBiology #SingleParticleAnalysis @uvmvermont...#IUCr https://journals.iucr.org/paper?S205979832600080X

Nature 🤝 Ornithology .. who knew .. www.nature.com/natcities/

This is 252 R01s, only. The math is quite devastating

Jeremy Berg@jeremymberg.bsky.social · 6mo ago

New and competitive renewal awards. The number of awards is 569 compared with more than 2200 through the same date in earlier fiscal years. All ICs have now made awards except for NIAAA, NCCIH, NLM, FIC, and OD. NEI (Eye Institute) made its first award during the new period. 3/4

This may end up being a hot take, but two things can be true at once: the new SciENcv is a pain, and it won't really affect things too much as most reviewers (...check notes...) actually use google/google scholar/REPORTER already

Soragni:Lab@alice.soragnilab.com · 6mo ago

Maybe, and just maybe and controversially so, this buys into the concept that, by and large, reviewers will use google or google scholar + reporter, so why bother?? Obviously not a fan either, but there is the reality of what people actually do when reviewing applications that is of some comfort

Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 6mo ago

Organelle communication networks rewire to support lipid metabolism during neuronal differentiation https://www.biorxiv.org/content/10.64898/2026.02.10.704675v1

Congrats to all the authors! #ARTNetPublication

Soragni:Lab@alice.soragnilab.com · 6mo ago

Proud of this review on centering models and next gen techs to address and prevent acquired resistance in cancer. Cements the work that our working group within @nciartnet.org has done over the last couple years, glad it resonated with people

Of so many things to be infuriated about, this is perhaps my biggest gripe. Pancreatic cancer patients, who face a future without hope, are being denied a potential game-changing therapy www.mskcc.org/news/can-mrn...

In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group

Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.

mskcc.org

BadgerNoonan@badgernoonan.bsky.social · 6mo ago

Crushing the mRNA industry in the US also probably destroys a bunch of cures for various cancers just as an FYI.

Proud of this review on centering models and next gen techs to address and prevent acquired resistance in cancer. Cements the work that our working group within @nciartnet.org has done over the last couple years, glad it resonated with people

Nature Reviews Cancer@natrevcancer.nature.com · 6mo ago

🥳 Our 3rd most downloaded #REVIEW in 2025: Acquired resistance in cancer: towards targeted therapeutic strategies #therapyresistance #cancertherapy @NatResCancer #NRCtop10of2025

Helen Branswell 🇨🇦@helenbranswell.bsky.social · 6mo ago

FDA's decision not to accept Moderna's flu vaccine filing has sent shock waves through pharma. "When there’s uncertainty about the path to approval & the reliability of the process, that really has pretty serious consequences,” one player told @jasonmast.bsky.social. www.statnews.com/2026/02/12/f...

This city has a way

With so much going on, in life and country, I have not been here as much as I used to. Posting about this big career change and reading the reactions, comments, and jokes, made me feel right back at home. Y'all know me too well. This space, like Twitter in the before time, is something else

Really nice article describing the molecular mimicry behind VITT in a very accessible manner. Original paper here: www.nejm.org/doi/full/10.... We all learned something, in this process.

Kai Kupferschmidt@kakape.bsky.social · 6mo ago

Ok, I know promised a thread on the fascinating and important new research explaining what happened with the rare, serious side effects of AstraZeneca's and Johnson&Johnson's Covid-19 vaccines. So, @science.org story is here and 🧪🧵 is coming: www.science.org/content/arti...