Congrats Aparna and team!

@bhadurilab.bsky.social · 5d ago

Congratulations to Jessenya Mil and Jose Soto on their published paper, online now!! We are so excited that this is out! www.cell.com/cell/fulltex...

Want to help? Great job security these days… oh and you can telework 3d/wk until October 😬 www.usajobs.gov/job/867528600

Grants Management Specialist

The incumbent performs limited grants management analysis assignments that are developmental and recurring in nature including functions such as the following: assisting a higher-level specialist in c...

usajobs.gov

Max Kozlov@maxkozlov.bsky.social · 3mo ago

NEW: A serious staffing shortage — of the Trump admin's own making — is delaying the agency's ability to send billions to universities around the country, leaving labs reeling in the meantime. “I thought we were at rock bottom”, a senior NIH official said. “We are below rock bottom now.”

Congratulations to Dr. Aparna Bhaduri for receiving the 2026 Pershing Square Sohn Cancer Prize, a national award recognizing innovative early-career scientists pursuing bold approaches to cancer research! 🎉 🔗 bit.ly/4tkEE0Q #ResearchPowersProgress

Aparna Bhaduri awarded Pershing Square Sohn Cancer Prize for advancing glioblastoma research

Dr. Aparna Bhaduri, assistant professor of medicine and biological chemistry at the David Geffen School of Medicine at UCLA, has been named a recipient of the 2026 Pershing Square Sohn Cancer Prize, a...

bit.ly

Had a blast visiting UCLA and sharing my work at the Emerging Genomic Scientists Symposium 😊 thanks @mfwells.bsky.social & the organizing committee for the opportunity and the fantastic program! 🙏🙏

Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.

Ahead of #WorldParkinsonsDay 🧠, we’re highlighting the work of Dr. Avi Samelson, who seeks to uncover the mechanisms that drive protein aggregation — a hallmark of neurodegenerative diseases like Parkinson’s. Learn more about his research: https://stemcell.ucla.edu/member-directory/avi-samelson-phd

Artemis II Astronaut Decapitated By Telephone Pole After Sticking Head Out Window

🚨 New lab website is now live 🚨 mfwellslab.com Stop by to take a look at our ongoing projects, learn about the amazing people on the team, and browse official lab merch including Wells Lab shower curtains (I am not joking).

This grant is the reason I drink coffee. We started writing in 2023 for the CIRM ReMIND-L initiative. The late night sessions forced me into the coffee world for the first time in my life at 38. Thanks CIRM for supporting our UCLA team and cell village experiments to study ASD and schizophrenia.

UCLA Broad Stem Cell Research Center@uclastemcell.bsky.social · 5mo ago

UCLA researchers led by Dr. Daniel Geschwind have been awarded a $13.9M grant from @cirmnews.bsky.social to use stem cell models to identify drug targets for autism and schizophrenia — conditions that affect tens of millions of people in the U.S. 🔗 bit.ly/4tg4zY9 #ResearchPowersProgress

www.sciencedirect.com/science/arti...

Beyond the baseline: mapping the context-specific regulatory landscape of disease

Genome-wide association studies have identified thousands of intergenic variants associated with disease, most of which are presumed to act by affecti…

sciencedirect.com

We're hiring villagers! We are looking for a lab technician to help us discover how gene-by-environment interactions shape the developing brain via in vitro cell villages. Please DM me or visit our website at mfwellslab dot com for more info. Deadline to apply is March 11th: tinyurl.com/34seyjaj

Laboratory Assistant II - Human Genetics - UCLA Health Careers - Job #29031 - Los Angeles, CA

Take a look at a great career opportunity where you can make a real difference at UCLA Health

uclahealthcareers.org

Happy to see this work out now in Genome Biology! Check out the final version here for your FACS DMS needs: link.springer.com/article/10.1...

Accurate variant effect estimation in FACS-based deep mutational scanning data with Lilace - Genome Biology

Deep mutational scanning (DMS) coupled with fluorescence-activated cell sorting (FACS) provides a high-throughput method to link genetic variants with quantitative molecular phenotypes. Analysis of th...

link.springer.com

Jerome@jeromics.bsky.social · last yr.

Check out our new preprint on Lilace, a statistical tool for scoring FACS-based deep mutational scanning experiments! Lilace directly models the shift between variant fluorescence distributions and provides score uncertainty estimates to better assess reliability and reproducibility. (1/3)

Before I turn 40 tomorrow, I want to share some advice: Beware bragging about your kids. Last month, I was proudly telling everyone that my 3-yr-old son loved mature artists like Childish Gambino, Radiohead, & Gorillaz. Today, he made me play "Taco Farts" by Mr. Farts 7 times en route to daycare.

Excited to finally share what I’ve been working on during my PhD 😊 Best holiday gift EVER! We just posted a new preprint from the @dphansti.bsky.social 👇 Preprint: www.biorxiv.org/content/10.6... 🧵

Stress-induced loss of CTCF reveals an alternative, promoter-based mode of cohesin looping

Cells continually encounter environmental stressors that challenge homeostasis. How three-dimensional (3D) chromatin structure contributes to these stress responses, particularly under hyperosmotic co...

biorxiv.org

New story in STAT with data about Early Stage Investigators www.statnews.com/2025/12/18/n... 1/4

NIH funding rates for early-career researchers plunged in 2025, new data show

A Trump administration change to how NIH awards grants has sharply reduced early-stage investigators’ odds of securing funding.

statnews.com

Nice preview of our paper by Hanwen Yu and Yan Liu. Generating 3D mouse organoids for cortex development and evo-devo: Developmental Cell www.cell.com/developmenta...

Generating 3D mouse organoids for cortex development and evo-devo

How do cis-regulatory differences, across mouse subspecies over timescales, shape cell-type specification and maturation during corticogenesis? In this issue of Developmental Cell, Medina-Cano et al. ...

cell.com

another must-read from @sashagusevposts.bsky.social

Sasha Gusev@sashagusevposts.bsky.social · 8mo ago

I wrote about the bizarre case of Herasight, the embryo selection company going all in on eugenics.

NEXT TUE: DDD seminar, Dec. 16, 2025 @ 1PM Eastern US: Dr. Tommy Vierbuchen @tvierbuchen.bsky.social will share his recent work on on cell villages using outbred mice: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". carlocolantuoni.org/seminar

Are you a senior grad student or new post-doc in genetics/genomics? Apply now for the 2026 Emerging Genomic Scientist Symposium hosted by the UCLA Human Genetics department. To apply: medschool.ucla.edu/about/depart... DM me if you have any questions and please spread the word

We used rabies virus 👾 to map how #psilocybin modifies long-range circuits 🧠, revealing network-specific reorganization that we didn’t expect. The full study is now online at Cell. @cp-cell.bsky.social Paper 👉 www.cell.com/cell/fulltex... Thread for a synopsis 👉 bsky.app/profile/alex...

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks

Psilocybin reshapes brain networks through activity-dependent plasticity, including a weakening of recurrent cortical loops that could underlie its therapeutic effects.

cell.com

Alex Kwan@alexkwan.bsky.social · last yr.

New preprint + thread 🧵 #Psychedelics induce the formation of new synapses, but where do they connect? Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks. www.biorxiv.org/content/10.1... 1/12

Someone get me (genetic epidemiologist) & my husband (school psychologist) on a podcast bc our rants on these people are...fiery. We spent 5y in the bay around these folks and oh boy. I'm also so sick of these puff pieces that avoid saying plainly what this actually is. Shoddy science for eugenics.

Hypervisible @hypervisible.blacksky.app · 8mo ago

Tech bros 🤝 eugenics

Not to brag, but Steve gives a shout out to my 3-year-old son in the intro of this book. (I lied, this is a brag) (Also, go buy this book, it is great)

Steve Ramirez@okaysteve.bsky.social · 9mo ago

Book launch day is here 🚀 How to Change a Memory, in physical and audio form: www.amazon.com/How-Change-M... and here's a preview of one of the book's central themes: memories change and, as a result, we change too🧠. www.statnews.com/2025/11/04/a...

Applications are open for the Postdoctoral Enrichment Program (PDEP)—supporting postdocs as they advance cutting-edge research and build thriving scientific careers. Learn more & apply: bwfund.org/pdep #bwfpdep

Soooooo cool Bart De Strooper's lab used microglia villages to show that Alzheimer’s polygenic risk translates into a stronger immune response to amyloid assets-eu.researchsquare.com/files/rs-779...

NEXT TUE: DDD seminar, Nov. 18, 2025 @ 1PM Eastern US: Continuing our focus on approaches to the study of many pluripotent stem cell lines, Dr. Michael Wells @mfwells.bsky.social will share his recent work on "cell villages". seminar info: carlocolantuoni.org/seminar [repost to spread the word]

The first (of hopefully many) reports to come from our collaboration with @hjp.bsky.social We present a new type of cell fitness assay that allows you to both quantify and explain differences across human donors in cell proliferation and sensitivity to environmental toxicants.

bioRxiv Genetics@biorxiv-genetic.bsky.social · 10mo ago

Cell villages and Dirichlet modeling map human cell fitness genetics https://www.biorxiv.org/content/10.1101/2025.09.26.678880v1

Super excited to get this out. This collab started a few years ago and is the first paper from it. Here, with experimental and computational approaches we: 1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs bsky.app/profile/bior...

bioRxiv Genetics@biorxiv-genetic.bsky.social · 10mo ago

Cell villages and Dirichlet modeling map human cell fitness genetics https://www.biorxiv.org/content/10.1101/2025.09.26.678880v1

New #cilia preprint alert Our latest manuscript is now live on bioRxiv: "The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity" We hope you enjoy reading it! www.biorxiv.org/content/10.1...

The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity

The capacity of neurons to maintain stable activity levels through homeostatic plasticity is essential for proper brain function. Primary cilia, which are non-motile, antenna-like organelles projectin...

biorxiv.org

CRISPR activation restores expression of a haploinsufficient neuronal sodium channel, rescuing neuronal deficits associated with multiple neurodevelopmental disorders. #NBThighlight www.nature.com/articles/s41...

CRISPR activation for SCN2A-related neurodevelopmental disorders - Nature

Using SCN2A haploinsufficiency as a proof-of-concept, upregulation of the existing functional gene copy through CRISPR activation was able to rescue neurological-associated phenotypes in Scn2a haploin...

nature.com

Good morning everyone! So, I wrote a book (!!) and it’s coming out November 4th in physical and audiobook form. It’s called *How to Change a Memory* www.amazon.com/How-Change-M...

How to Change a Memory: One Neuroscientist’s Quest to Alter the Past

Buy How to Change a Memory: One Neuroscientist’s Quest to Alter the Past on Amazon.com ✓ FREE SHIPPING on qualified orders

amazon.com