Sarah Cohen

@cohenlaboratory.bsky.social

Cell biologist at UNC interested in organelles, lipids, neurodegenerative disease, and light microscopy. https://cohenlaboratory.web.unc.edu

Throwback to our 1st MCS Meeting back in 2024! Luca, Thomas & Rosie look forward to reuniting in Mexico later this year, and welcoming our new, and returning delegates from the MCS community Our final programme is now live, so visit the website here to check it out: bit.ly/4fo4Vqc

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Beyond delighted to share our amazing collaboration with Thierry Alquier's lab @alquierthierry.bsky.social on a conserved role for neuronal lipid droplets in regulating energy homeostasis in vivo led by Celena Cherian, Romane Manceau, Danie Majeur, and Colin Miller www.nature.com/articles/s42... /1

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism

In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.

nature.com

Awesome paper and super useful resource of CRISPR-based screens to identify regulators of #LipidDroplet biology under different metabolic conditions: crisprlipid.org

James Olzmann@olzmannlab.bsky.social · 5mo ago

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

Thrilled to share that the first part of my PhD work from @cohenlaboratory.bsky.social lab is now on bioRxiv! www.biorxiv.org/content/10.6... Check out the threads below:

biorxiv.org

Sarah Cohen@cohenlaboratory.bsky.social · 6mo ago

During #NeuronalDifferentiation, #organelles dramatically reorganize. #Microtubules are essential tracks for transport. But are they just highways, or can they instruct organelle behavior? Are tubulin modifications a regulatory code that guides organelle position or function? 1/9

I'm delighted to present TWO new preprints from my lab, led by @mczanellati.bsky.social and @sherryhsu.bsky.social, about how #organelles remodel throughout #NeuronalDifferentiation. Check out the threads about their papers below:

Sarah Cohen@cohenlaboratory.bsky.social · 6mo ago

Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13

During #NeuronalDifferentiation, #organelles dramatically reorganize. #Microtubules are essential tracks for transport. But are they just highways, or can they instruct organelle behavior? Are tubulin modifications a regulatory code that guides organelle position or function? 1/9

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 6mo ago

Tubulin acetylation governs organelle remodeling and lysosomal reformation during neuronal differentiation https://www.biorxiv.org/content/10.64898/2026.02.13.705749v1

Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 6mo ago

Organelle communication networks rewire to support lipid metabolism during neuronal differentiation https://www.biorxiv.org/content/10.64898/2026.02.10.704675v1

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule rdcu.be/e3Ris

Have a look (and read) at our newest Review below! 🥳 Great discussion on how lipid droplets interact with other organelles, written by @cohenlaboratory.bsky.social and @hennelab.bsky.social

Sarah Cohen@cohenlaboratory.bsky.social · 7mo ago

Such a pleasure to write this review on #LipidDroplet heterogeneity, dynamics and #organelle interactions with Mike @hennelab.bsky.social ! Thank you to the editorial team @natrevmcb.nature.com and to Yoni Malis for assistance with draft illustrations