New blog post! I analyse the new hac@v6.0.0 basecalling model from @nanoporetech.com and discuss the conspicuous lack of a new sup model: rrwick.github.io/2026/06/11/d...

Tim Somerset is a postgraduate Research Assistant in the Fitzgerald Group at the Early Cancer Institute, where he uses computational and statistical approaches to study oesophageal cancer.  Discover what inspires Tim’s work ➡️ zurl.co/rVlSL #FocusOnCamCancer

Interesting data and analysis behind NeurIPS's new AI policy blog.neurips.cc/2026/06/02/a...

It was my pleasure to present my HRD work at @Oxford Nanopore London Calling 2026. It was nice to meet so many new and old friends in the community. Looking forward to future meetings to share my work, and to inspire more researchers to join the community! #LC26 #Nanoporeconf

The new long read cDNA kit by @nanoporetech.com is a major upgrade (and improvement!), substantially increasing read length, with a strong impact on transcript discovery and quantification. We @goekelab.bsky.social have tested this in the beta release, more updates soon #nanoporeconf

Critically ill infants need rapid treatment. Ni-Chung Le, through the Asia-Pacific N‑Care Project, showed how nanopore could deliver answers in ~5 days, changing management for half of ICU cases across the region. https://bit.ly/4dU0a8f #Nanoporeconf

One biomarker isn’t enough to guide cancer treatment. At #NanoporeConf, Alvin Ng will explore how biomarker detection with Adaptive Sampling could transform how treatment response is predicted. https://bit.ly/41Jt2cA

HERRO has been published in @nature.com nature.com/articles/s41.... This achievement is a result of the great work by Dominik Stanojevic, with contributions from Dehui Lin, @sergeynurk.bsky.social, and Paola Florez de Sessions Welcome to the era of high-quality genome assemblies supported by AI.

Half of esophageal adenocarcinoma have no detectable Barrett's esophagus, but is the pre-cancer stage essential for cancer development? Rebecca Fitzgerald lab & alumni analyzed epidemiological & molecular data of more 3800 patients and found a single pathway to EAC www.nature.com/articles/s41...

Why should tumor whole genome sequencing (WGS) be done for cancer? In real practice of medicine study of 888 patients with solid cancers, WGS directly led to clinical consequences in over 40% www.nature.com/articles/s41...

Real-world clinical utility of tumor whole-genome sequencing in solid cancers - Nature Medicine

In a real-world cohort of 888 patients with solid cancers receiving whole-genome sequencing profiling, actionable biomarkers were identified in 73% of patients, and targeted therapies were associated ...

nature.com

Looking forward to London Calling 2026! I'll share how we built a long-read HRD test using adaptive sampling. With a single assay, we can now capture multiple complex biomarkers, dive deeper into individual tumours and uncover new layers of cancer biology. #nanoporeconf More: echo.walls.io/cAgvWLR

Transformer-based AI has boosted @nanoporetech.com sequencing accuracy, but at a cost to portability due to GPU demands. Our new work, spearheaded by Sara Bakic, introduces Campolina link.springer.com/article/10.1... to improve nanopore signal segmentation for event-based mappers.

Campolina: a deep neural framework for accurate segmentation of nanopore signals - Genome Biology

Nanopore sequencing enables real-time, long-read analysis by processing raw signals as they are produced. A key step, segmentation of signals into events, is typically handled algorithmically, struggl...

link.springer.com

Last day at #InSiGHT2026 with a session for Early-onset colorectal cancers that I had the pleasure to co-chair. Thank you for thoughtful discussions with the speakers & audience ! Lastly, thank you for the support from @nanoporetech.com on the project and more updates to come!

Day 2 at #InSiGHT2026 with thought provoking talks on the molecular features of Lynch Syndrome. Thankful for the opportunity to give a talk in collaboration with Illumina Simeen and Shunhua Han on the newly released TruPath Genome. Looking forward to the next 2 days of talks!

Wonderful opportunity to work on cancer genome reconstruction with long reads!

Mile Sikic@msikic.bsky.social · 8mo ago

I’m recruiting a postdoc to work on algorithms for cancer genome reconstruction. We have access to a rich set of tumour samples sequenced across multiple technologies. If interested, feel free to DM. Please share.

Looking for a postdoc in computational biology? We are looking for a postdoc candidate apply for the fellowship 'Juan de la Cierva' for a project on long-read transcriptomics, multiomics, spatial transcriptomics, single-cell long-reads. Deadline is approaching!! (December 10th)

The structure of the bacterial genotoxin colibactin bound to DNA shows how it might contribute to cancer risk @science.org www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

Excited to see this thought provoking piece of work now published. So much more to learn about mutagenesis in healthy tissue.

Nuria Lopez-Bigas@nlbigas.bsky.social · 10mo ago

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died. Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology. More: www2.mrc-lmb.cam.ac.uk/john-gurdon-... #LMBNews

Rest in peace Jane Goodall, a true giant among scientists. Your breakthroughs into the secret lives of chimpanzees viewed through an anthropomorphic lens – without yet knowing that science had forbidden it – changed science forever, and with it how we see ourselves.

Elegant work to unveil the etiology behind the ubiquitous SBS5 mutational signature. Glad to be in the audience to see this work presented and I have already put it on my reading list.

Molly Przeworski@mollyprz.bsky.social · 11mo ago

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n www.biorxiv.org/cgi/content/...

We are all somatic mutation mosaics. "There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome." @nature.com nature.com/articles/s41...

The Somatic Mosaicism across Human Tissues Network - Nature

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

nature.com

If you don’t have time to take a walk, then you don’t have time to do science. Charles Darwin would take two walks every day on his "thinking path", not as a break from science, but as a crucial part of it.

Excited for the talks on the amazing biology of ecDNA! Interested in ecDNA in esophageal cancers and long read sequencing? Always happy to chat! #CancerGrandChallenges #CGCecDNA

Attending BRCA Symposium 2025 and enjoying a master class from Ralph Scilly on HRD. I will also start calling SBS3 bland from now on.

Interesting work from Khi Pin Chua, PhD on precise characterization of complex repeat regions in cancer genomes at #AACR25. Catch him at poster 2 in section 46 (#6288) until 5 PM! #PacBio

“If left unchallenged, a rising wave of white nationalism in many parts of the globe could threaten the progress that has been made in science — and broader society — towards a more equitable world,” writes Genevieve Wojcik in a Comment article for Nature. 🧬 🧪

Eugenics is on the rise again: human geneticists must take a stand

Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics.

go.nature.com

Maybe I need to look at some head and neck cancer to study both DNA repair and ecDNAs. Come look for me at #AACR25 if you like to chat!

Maybe I need to look at some head and neck cancer to study both DNA repair and ecDNAs. Come look for me at #AACR25 if you like to chat!

Yes! - we are hiring @yale.edu - links below...

Craig Anderson@craigandersn.bsky.social · last yr.

I'm biased, but I loved it, great talk!! Don't forget @s-j-aitken.bsky.social is hiring! She's a great scientist and person- you couldn't find a better PI.