@amandagwee.bsky.social
Gen paed, ID physician, clinical pharmacologist. Researcher, interest in optimising antimicrobial use in kids. Views my own
Among adults with #AcuteSinusitis, standard-dose amoxicillin-clavulanate did not reduce treatment failure compared with amoxicillin, while overall failure and hospitalization rates were low in both groups. #ESCMIDGlobal2026 @escmid.bsky.social ja.ma/4mD2ymI
We are hiring! Interested in being a research coordinator for paediatric antimicrobial trials @mcri.bsky.social? See career10.successfactors.com/sfcareer/job...
career10.successfactors.com
Pkpd study in immunocompromised kids showing GCV AUC24 corresponding to 90% maximal suppression and elimination effects was approximately 40-100 mg/L·h. WCC significantly affected the viral decline rate. Time for routine tdm? bpspubs.onlinelibrary.wiley.com/doi/10.1002/... #cmv #pedsid #TxIDChat
BPS Publications
Aims Ganciclovir (GCV) is commonly used to treat cytomegalovirus (CMV) infections in immunocompromised children. Currently, the therapeutic target for effective treatment is unclear: Adult studies s...
bpspubs.onlinelibrary.wiley.com
Excited to publish this review with kidsdose.org.au network summarising the available clinical trial, pk data and evidence gaps in antibiotic tx for resistant Gram neg infections in kids. www.sciencedirect.com/science/arti.... #idsky #paedsid #pedsid @mcri.bsky.social @lancetrh-wpac.bsky.social
Drug-resistant gram-negative bacterial infections in children in the Oceania region: review of the epidemiology, antimicrobial availability, treatment, clinical trial and pharmacokinetic data, and key...
Gram-negative bacterial infections remain a major cause of morbidity and mortality in children and neonates globally, compounded by the rise of antimi…
sciencedirect.com
Vancomycin Taper trial presented by @dremilymcd.bsky.social #ESCMID2025. In people who get better by day 10 should we stop or give taper? Reduced recurrences by primary outcome timepoint but the KM suggests it may be just delaying rather than truly preventing recurrence? #IDSky
All you need to know about vancomycin dosing in adults and kids led by @leggwamy.bsky.social and @tonylai.bsky.social
Nadine Hillock@nadinehillock.bsky.social · last yr.Great comprehensive summary on the safe & effective use of vancomycin in the Australian Prescriber australianprescriber.tg.org.au/articles/saf... Congrats to the authors! @leggwamy.bsky.social @tonylai.bsky.social @feliciadevchand.bsky.social @amandagwee.bsky.social Indy Sandaradura #vancomycin #AMS
Great comprehensive summary on the safe & effective use of vancomycin in the Australian Prescriber australianprescriber.tg.org.au/articles/saf... Congrats to the authors! @leggwamy.bsky.social @tonylai.bsky.social @feliciadevchand.bsky.social @amandagwee.bsky.social Indy Sandaradura #vancomycin #AMS
Safe and effective use of vancomycin
Vancomycin is an important antimicrobial for the treatment of Gram-positive infections. To optimise efficacy and minimise toxicity, monitoring the area under the vancomycin concentration–time curve ov...
australianprescriber.tg.org.au
Lots of work on this in kids. @amandagwee.bsky.social the BOSS on this topic & @alisonboast.bsky.social her badass sidekick! pubmed.ncbi.nlm.nih.gov/32412727/
Twice- and Thrice-daily Cephalexin Dosing for Staphylococcus aureus Infections in Children - PubMed
Our study proposes a BID and TID cephalexin dosing regimen that can be prospectively evaluated. Through reducing the dose frequency of this widely prescribed antibiotic, we can reduce the medication b...
pubmed.ncbi.nlm.nih.gov
Systematic review on posaconazole levels & clinical outcomes of IFI in kids. All but 1 breakthrough IFI occurred with serum levels ≤0.7mg/L. For IFI treatment, no association between trough >1.0mg/L & efficacy. Poor outcomes seen with levels between 0.2-4.8mg/L. pubmed.ncbi.nlm.nih.gov/40037294/
Relationship between posaconazole concentrations and clinical outcomes in paediatric cancer and haematopoietic stem cell transplant recipients - PubMed
This review supports current recommendations for posaconazole prophylaxis in paediatric oncology and HSCT recipients. The absence of a clear correlation found between serum trough concentrations and t...
pubmed.ncbi.nlm.nih.gov
Reduction in sputum pseudomonas bacterial load (live and dead) associated with improvement in FEV1 in children with CF receiving antibiotics. No correlation between change in total sputum bacterial load and improvement in FEV1. #Idsky pubmed.ncbi.nlm.nih.gov/40090524/
Relationship between sputum bacterial load and lung function in children with cystic fibrosis receiving tobramycin - PubMed
A greater reduction in total sputum P. aeruginosa bacterial load (live + dead) was associated with improved lung function (FEV<sub>1</sub>) in children with CF receiving tobramycin.
pubmed.ncbi.nlm.nih.gov
📚 Our findings, along with our earlier study showing that #BCGvaccine increased risk of symptomatic [but not severe] #COVID-19, suggest that BCG vaccination does not enhance immunity to #SARSCoV2 or COVID-19 vaccines 🌍✨ #IDsky #Immunosky www.sciencedirect.com/science/arti...
BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial
Bacille Calmette-Guérin (BCG) vaccine has immunomodulatory effects that may provide protection against unrelated infectious diseases. We aimed to dete…
sciencedirect.com
Vaccines and immunization fact sheets you can't find on CDC website anymore are archived at the link below. May be helpful to bookmark this for future reference. www.immunize.org/vaccines/vis...
Vaccine Information Statements (VISs) Overview | Immunize.org| Immunize.org
Find materials on legal requirements to give VISs to patients before vaccinating.
immunize.org
Look at that - @bradspellberg.bsky.social gently triggering world war CRO vs CTX! BD or OD??? @alisonboast.bsky.social @amandagwee.bsky.social pubmed.ncbi.nlm.nih.gov/39377581/
Population pharmacokinetic modeling of ceftriaxone in cerebrospinal fluid in children: should we be using once- or twice-daily dosing for meningitis? - PubMed
Guidelines for bacterial meningitis in children recommend intravenous ceftriaxone 50 mg/kg (max 2 g) twice daily (BD) or 100 mg/kg (max 4 g) once daily (OD), leaving the decision regarding the dose fr...
pubmed.ncbi.nlm.nih.gov
🆕💫Retrospective cohort study #CMI AKI is a frequent complication of S. aureus bacteraemia and is associated with 30-day mortality Not “a cute” complication: phenotypic analysis of acute kidney injury in S. aureus bacteraemia #idsky #EMIMCC www.clinicalmicrobiologyandinfection.com/article/S119...
DEFINE_ME
clinicalmicrobiologyandinfection.com
Slipping into 2024 right as the door closes is the publication of the AGAR Kids manuscript depicting antibiotic resistance trends in gram-neg bacteraemia isolates from children over nine years @ausantibiotics.bsky.social #AMR #MedSky #Microsky #IDsky #pediatrics #newarticle doi.org/10.1093/jpid...
Antimicrobial Resistance in Enterobacterales, Acinetobacter spp. and Pseudomonas aeruginosa Isolates From Bloodstream Infections in Australian Children, 2013–2021
Pediatric gram-negative bacteremia is associated with considerable morbidity and mortality. Enterobacterales resistance is increasing in Australian pediatr
doi.org
Reviews of antimicrobial dosing: 1. Anti-fungals: doi.org/10.1093/ofid... 2. All-antimicrobials: ccforum.biomedcentral.com/articles/10.... Systematic Reviews: 1. Definitions of ECMO infections: www.ajicjournal.org/article/S019... 2. Use of ppx antibiotics: journals.lww.com/asaiojournal...
Antifungals in Patients With Extracorporeal Membrane Oxygenation: Clinical Implications
This review summarizes antifungal use in ECMO patients, exploring specific substances, dosing, TDM and ECMO-related factors from a clinical point of view.
doi.org
Broad-Spectrum Antibiotics Linked To Increased Risk For Adverse Drug Events Among Outpatients With CAP #IDSky Antimicrobial stewardship efforts are needed to promote judicious use of antibiotics, and ultimately decrease antibiotic-related ADEs academic.oup.com/cid/advance-...
Comparative Safety of Different Antibiotic Regimens for the Treatment of Outpatient Community-Acquired Pneumonia Among Otherwise Healthy Adults
Among otherwise healthy, nonelderly adults treated for community-acquired pneumonia in the outpatient setting, each broad-spectrum antibiotic regimen was a
academic.oup.com
Linezolid May Be Alternative For Adjunctive Antitoxin Therapy In Adults Hospitalized With Invasive GAS Infection Receiving β-Lactam Therapy #IDSky www.thelancet.com/journals/lan...
Adjunctive linezolid versus clindamycin for toxin inhibition in β-lactam-treated patients with invasive group A streptococcal infections in 195 US hospitals from 2016 to 2021: a retrospective cohort study with target trial emulation
In this emulated trial of adult patients with invasive GAS infections treated with β-lactam, linezolid appeared non-inferior to clindamycin suggesting linezolid as an alternative for adjunctive antitoxin therapy.
thelancet.com
#IDSky colleague from New Zealand @maxgbloomfield.bsky.social sent us his study on environmental benefits when they switched TID cefuroxime to once a day ceftriaxone. They had a 383kg waste reduction! Nice to connect with #IDSky across the globe on sustainability. pubmed.ncbi.nlm.nih.gov/38696830/
Incorporating patient, nursing and environmental factors into antimicrobial stewardship: effects of simplifying treatment from cefuroxime to ceftriaxone - PubMed
This simplification of our AG from a three-times-daily to a once-daily antibiotic resulted in considerable savings for our hospital (roughly 1.7 full-time equivalent nurses and over a tonne of waste y...
pubmed.ncbi.nlm.nih.gov
WHO recommendations for management of serious bacterial infections in infants aged 0–59 days 8 December 2024 www.who.int/publications...
WHO recommendations for management of serious bacterial infections in infants aged 0–59 days
The World Health Organization (WHO) has developed guidelines for the management of infants aged 0-59 days with serious bacterial infections (sepsis, meningitis, and pneumonia) in hospital and also out...
who.int
Pharmacodynamic studies indicate that anaerobic killing is optimized when the plasma AUC) to MIC ratio is ≥70:1; the probability of achieving this target with 1000mg/d of metronidazole is > 99% against B. fragilis that exhibit MICs < 2mg/L #idsky #medsky #EMIMCC
Antibiotic Steward 🅱️C🆔🅿️🌟@absteward.bsky.social · 2y ago🆕️✨️The largest study to date of patients with Bacteroides spp. bacteremia Metronidazole 500mg q12h dosing was not associated with worse outcomes compared to metronidazole 500mgq8h Metro:500mgq12h must be used for most types of infections #idsky #medsky #EMIMCC www.sciencedirect.com/science/arti...
🔥The ADAPT-Sepsis RCT🔥 Daily PCT-guided protocol 🔽 total antibiotic duration & had noninferior all-cause mortality compared with standard care. No difference was found in total Abx duration between standard care & daily CRP-guided protocol CRP failure #idsky #EMIMCC jamanetwork.com/journals/jam...
Biomarker-Guided Antibiotic Duration for Patients With Suspected Sepsis
This clinical trial assessed whether treatment protocols for monitoring C-reactive protein or procalcitonin safely reduced the amount of time critically ill adults with suspected sepsis received antib...
jamanetwork.com
🆕️✨️Retrospective cohort study Oral doxycycline for the treatment of ocular syphilis may be safe and effective as IV penicillin in a selected subset of patients who completed an extended oral antibiotic #idsky #medsky #AMSsky jamanetwork.com/journals/jam...
Outpatient Oral Doxycycline Therapy for Ocular Syphilis
This cohort study compares the outcomes of oral doxycycline therapy with those of intravenous penicillin therapy among patients with ocular syphilis.
jamanetwork.com
This #StrepA paper was a LONG labour of love from a great team 😊 Equal first & senior author credits buried at the very end, so I want to highlight the critical contributions of Dr Hannah Frost & @njmoreland.bsky.social & Dr Danika Hill @precisionvaxlab.bsky.social rdcu.be/d2gBV
Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections
Nature Communications - Streptococcus pyogenes is a deadly bacteria without a vaccine. Here, researchers measured antibodies in serum and saliva from a strep throat human challenge trial. Baseline...
rdcu.be
Thanks @absteward.bsky.social. The link to the original pop pk study on which the dosing regimen was based is pubmed.ncbi.nlm.nih.gov/32412727/
Twice- and Thrice-daily Cephalexin Dosing for Staphylococcus aureus Infections in Children - PubMed
Our study proposes a BID and TID cephalexin dosing regimen that can be prospectively evaluated. Through reducing the dose frequency of this widely prescribed antibiotic, we can reduce the medication b...
pubmed.ncbi.nlm.nih.gov
Antibiotic Steward 🅱️C🆔🅿️🌟@absteward.bsky.social · 2y agoThe standard four times daily cephalexin dose makes treatment adherence challenging 🆕️⚡️⚡️Retrospective #JAC Efficacy and tolerability of high-dose cefalexin 45 mg/kg/dose (maximum 1.5 g) three times daily in children with bone and joint infections #idsky academic.oup.com/jac/article-...
The standard four times daily cephalexin dose makes treatment adherence challenging 🆕️⚡️⚡️Retrospective #JAC Efficacy and tolerability of high-dose cefalexin 45 mg/kg/dose (maximum 1.5 g) three times daily in children with bone and joint infections #idsky academic.oup.com/jac/article-...
Efficacy and tolerability of high-dose cefalexin 45 mg/kg/dose (maximum 1.5 g) three times daily in children with bone and joint infections
AbstractBackground. Cefalexin, a first-generation cephalosporin, is commonly used as oral continuation therapy for paediatric bone and joint infections (BJ
academic.oup.com
