📣Exciting announcement 📣 The First Global Strep A Vaccine Conference Call for abstracts will open soon! 🌏Venue update: Kuala Lumpur, Malaysia, first week of February 2027 📝Abstract submissions open 30 July 2026. #GSAVConference2027 Read the full announcement here ⬇️ lnkd.in/eiu95fXm

Excited 1st SNAP result out @thelancet.com PSSA: Fluclox v BenPen thelancet.com/journals/lancet/article/PIIS0140-6736(26)00761-0/fulltext @nejm.org MSSA: Fluclox v Cefazolin nejm.org/doi/full/10.1056/NEJMoa2506905 Should change practice globally Privilege to help deliver trial with fantastic team

Excited to share an article that I've long awaited to share seeking to answer: What is the right dose of cephalexin/cefadroxil for SSTIs? We reviewed clinical studies & conducted PTA sims to elucidate this #IDSky @absteward.bsky.social accpjournals.onlinelibrary.wiley.com/doi/10.1002/...

Getting It Right the Second Time: How Can we Optimize First‐Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies ...

accpjournals.onlinelibrary.wiley.com

If Strep pyogenes had a walk up song (thought brought about by the most recent Breakpoints episode 🔥🧫) @sidpharm.bsky.social @joshosowicki.bsky.social podcasts.apple.com/us/podcast/b... #IDSky #MedSky #PharmSky open.spotify.com/track/0jfIKx...

Firestarter

The Prodigy · The Fat of the Land · Song · 1997

open.spotify.com

🆕 Episode of #Breakpoints GAS infections remain a global challenge. Dr. Shiranee Sriskandan, Dr. Josh Osowicki, and Dr. Tom Parks join host Dr. Erin McCreary to explore the evolving landscape of GAS. Tune in as we highlight practical pearls you can apply in your own practice. 🎧️ sidp.pinecast.co

Today, Coefficient Giving is launching the Strep A Vaccine Fund, a multi-donor initiative to accelerate vaccine development against one of the world's most neglected infectious diseases relative to its scale. Strep A kills ~639,000 people a year. There is no vaccine. I think that can change 🧵

The Society of Infectious Diseases Pharmacists and ESCMID are excited to release a new Breakpoints episode: ESCMID Global Trials: PETER PEN and ASTARTE Check it out!

0 reason to think things would be difft in non HIV, children, xenomorphs, non carbon based life forms, or any other excuses stubborn deniers have. My suggestion? Do some yoga. Meditate. Light incense. Relax. And stop torturing your patients with 2 weeks of amphoterrible. Subtle as always, I know.

Is It Time to Use Single-Dose Amphotericin B for HIV-Related Cryptococcal Meningitis in the USA? The answer is yes! doi.org/10.1001/jama...

Single-Dose Amphotericin B for HIV-Related Cryptococcal Meningitis

Cryptococcal meningitis remains a life-threatening opportunistic infection among people with advanced HIV, even in high-resource settings. For decades, the standard induction regimen in the United Sta...

doi.org

Pleased to share our brief commentary on how antiplatelet drugs such as ticagrelor (Brilinta) may have an intriguing beneficial action toward effective treatment of Staphylococcus aureus bacteremia and endovascular infection #drugrepurposing

Bridging specialties: repurposing platelet drugs prescribed by cardiologists to help infectious disease doctors treat Staphylococcus aureus bacteremia

The platelet is the most important cell in the bloodstream in providing endovascular immunity against Staphylococcus aureus bacteremia. Both quantitative and qualitative thrombocytopenia have been ...

tandfonline.com

From first hand clinical experience, meningococcal sepsis and meningitis are indelibly etched in my mind—diseases that can progress rapidly from flu-like symptoms to loss of life or limb—even in previously health children & young adults Vaccination had reduced rates up to 90% – don't give up now

As cases of a rare, deadly infection rise, doctors worry fewer teens will get vaccinated

Under Robert F. Kennedy Jr.’s guidance, the CDC no longer recommends routine vaccination to protect against meningococcal disease.

nbcnews.com

Pretty cool that Robin Patel picks Ouli Xie's @lancetmicrobe.bsky.social paper on SDSE and S pyogenes as one of her top 3 clinical microbiology papers for 2025! As expected, Robin does a great job explaining the paper. www.thelancet.com/journals/lan... @onisillos.bsky.social

Invasive Streptococcus dysgalactiae subspecies equisimilis compared with Streptococcus pyogenes in Australia, 2011–23, and the emergence of a multi-continent stG62647 lineage: a retrospective clinical...

We identified a substantial burden of invasive SDSE, dominated by the emergent stG62647 lineage. The contrasting epidemiology between species in the different Australian regions, during COVID-19 NPIs,...

thelancet.com

CMI Communications@cmicomms.bsky.social · 7mo ago

🎙️ Just published Communicable E44: Top clinical microbiology papers in 2025 Hosted by Annie Joseph & Josh Nosanchuk w/ invited guests Robin Patel & Fidelma Fitzpatrick Listen on #Communicable: https://share.transistor.fm/s/6e5c26ae #IDSky #clinmicro

How can we accelerate human trials of vaccines, therapeutics and diagnostics against priority pathogens in advance of epidemics and pandemics? Well, if we can identify safe, weakened versions controlled human infection model trials might be possible: journals.plos.org/plosntds/art... 🧪 🩺 #IDsky

Attenuated viral strains of priority pathogens for potential use in controlled human infection model studies: A scoping review

Author summary There are several families of viruses that scientists predict are most likely to cause a future pandemic, such as coronaviruses or Ebola. Studying these viruses ahead of time might mean...

journals.plos.org

1/2 Progress in vaccine development only happens when people are willing to step up. Challenge trials are one of the most powerful tools we have for speeding lifesaving vaccines. If we want faster, more equitable global health outcomes, we need to expand and support this research model.

Congratulations to Burrell St Sexual Health: First UK patient into SOS Global - Evaluating mucosal shedding of spirochetes in heterosexual individuals with syphilis. Great collaboration led by Melbourne Sexual Health Centre focused on understanding syphilis transmission.

In a trial in healthy U.K. adults who were challenged with S. Paratyphi A in a controlled human infection model, two doses of the candidate vaccine CVD 1902 led to protection against S. Paratyphi A infection. Full VASP phase 2b trial results: nej.md/3Lypfd5 #MedSky #IDSky

Want to come work on SNAP, BALANCE+, and STRAP? And change how we treat and manage bloodstream infections? See below. #IDSky

Sean Ong@seanong.bsky.social · 10mo ago

We are looking for candidates for a new fully-funded joint PhD position at the Universities of Toronto and Melbourne, working on RCTs in bloodstream infection (BALANCE+, SNAP, STRAP). More info here: forms.gle/H9TXEMkwM1cb... Please spread far and wide! @steventong.bsky.social #IDSky

AAMRI is thrilled to announce our 2025 AAMRI Rising Star Award Finalists, proudly sponsored by CSL. These outstanding researchers are shaping the future of health + medical research in Australia 👏 #2025AAMRIRisingStar aamri.org.au/news-events/... Winner announced 4 Nov at #2025AAMRIConvention

AAMRI announces 2025 Rising Star finalists showcasing our brightest young researchers - AAMRI

AAMRI is delighted to announce the finalists for the 2025 AAMRI Rising Star Award, proudly sponsored by CSL. The award shines a spotlight on the extraordinary talent driving the future of health and m...

aamri.org.au

I am exciting to publish our validated, lab-based model of oral gonorrhoea infection! With this model we can begin to understand how gonorrhoea behaves in the mouth (which is lacking) and screen for new compounds for interventions such as a gum to prevent infections. sti.bmj.com/content/earl...

Our new review “𝘛𝘩𝘦 𝘊𝘦𝘯𝘵𝘳𝘢𝘭 𝘐𝘮𝘱𝘰𝘳𝘵𝘢𝘯𝘤𝘦 𝘰𝘧 𝘝𝘢𝘤𝘤𝘪𝘯𝘦𝘴 𝘵𝘰 𝘔𝘪𝘵𝘪𝘨𝘢𝘵𝘦 𝘵𝘩𝘦 𝘛𝘩𝘳𝘦𝘢𝘵 𝘰𝘧 𝘈𝘯𝘵𝘪𝘣𝘪𝘰𝘵𝘪𝘤-𝘙𝘦𝘴𝘪𝘴𝘵𝘢𝘯𝘵 𝘉𝘢𝘤𝘵𝘦𝘳𝘪𝘢𝘭 𝘗𝘢𝘵𝘩𝘰𝘨𝘦𝘯𝘴” is out Compared to antibiotics, vaccines: ✓ Act prophylactically at low pathogen burden ✓ Less prone to inducing resistance due to multifactorial nature of immune pressure 🧵1/3

Exited to announce 2 EDCTP consortiums led @lshtm.bsky.social w partners in Europe & West, East & Southern Africa MAMS4CL will deliver seamless Phase 2-3 trial of treatments for Cutaneous Leishmaniasis. IVMKIDS will provide data on paediatric dosing ivermectin down to 5kg/weight for STH & Scabies.

Phenomenal piece of work by a great team across @mrcunitgambia.bsky.social @lshtm.bsky.social @sheffielduni.bsky.social - Delighted to have played a small part in combining epidemiology & immunology to shed light on what protection for #StrepA might look like & help advance vaccine development.

Alex Keeley@alexjkeeley.bsky.social · last yr.

🧵 Our paper out today in @naturemedicine.bsky.social www.nature.com/articles/s41... On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon 1/ #Immunosky #IDsky #MicroSky #globalhealth.

Fantastic to see this immense body of excellent work published! Well done @alexjkeeley.bsky.social and everyone involved 👏 #StrepA @floreyinstitute.bsky.social @molmicrosheffield.bsky.social

Alex Keeley@alexjkeeley.bsky.social · last yr.

🧵 Our paper out today in @naturemedicine.bsky.social www.nature.com/articles/s41... On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon 1/ #Immunosky #IDsky #MicroSky #globalhealth.

VERY excited by our latest work on StrepA below, but also rhe multiple collaborations and work to come off the back of this at MRCG

Alex Keeley@alexjkeeley.bsky.social · last yr.

🧵 Our paper out today in @naturemedicine.bsky.social www.nature.com/articles/s41... On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon 1/ #Immunosky #IDsky #MicroSky #globalhealth.

🧵 Our paper out today in @naturemedicine.bsky.social www.nature.com/articles/s41... On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon 1/ #Immunosky #IDsky #MicroSky #globalhealth.

A real pleasure to be a part of this beautiful new study on T cell responses in repeat controlled human infection vs natural infection with #schistosomes, spearheaded by @emmahoulder.bsky.social with many wonderful colleagues #helminths #ImmunoSky #IDSky 🪱 🧪 www.nature.com/articles/s41...

T cell responses in repeated controlled human schistosome infection compared to natural exposure - Nature Communications

In schistosomiasis-endemic regions, the cyclical nature of infection and treatment complicates understanding of host immune responses. Repeated controlled human Schistosoma mansoni infection, designed...

nature.com

Congratulations to 𝐃𝐎𝐂𝐓𝐎𝐑 𝐃𝐀𝐍𝐈𝐄𝐋 𝐒𝐔𝐍 on the successful defense of his PhD "𝘊𝘰𝘯𝘴𝘪𝘥𝘦𝘳𝘪𝘯𝘨 𝘵𝘩𝘦 𝘏𝘰𝘴𝘵-𝘗𝘢𝘵𝘩𝘰𝘨𝘦𝘯 𝘐𝘯𝘵𝘦𝘳𝘧𝘢𝘤𝘦 𝘧𝘰𝘳 𝘕𝘰𝘷𝘦𝘭 𝘈𝘱𝘱𝘳𝘰𝘢𝘤𝘩𝘦𝘴 𝘵𝘰 𝘛𝘳𝘦𝘢𝘵 𝘋𝘳𝘶𝘨 𝘙𝘦𝘴𝘪𝘴𝘵𝘢𝘯𝘵 𝘚𝘵𝘢𝘱𝘩𝘺𝘭𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘢𝘶𝘳𝘦𝘶𝘴" in the Biomedical Sciences Graduate Program as part of his dual degree training in the UCSD SSPPS PharmD/PhD Program

Thanks for the reference! And of course there's this classic from @tonybreu.bsky.social x.com/tony_breu/st...

Tony Breu on X: "1/ Why hasn't syphilis developed resistance to penicillin (PCN)? It took staph aureus about a year to demonstrate resistance. After 75 years, there has never been a reported case of treponema pallidum resistant to PCN. Let’s have a look at why this might be..." / X

1/ Why hasn't syphilis developed resistance to penicillin (PCN)? It took staph aureus about a year to demonstrate resistance. After 75 years, there has never been a reported case of treponema pallidum resistant to PCN. Let’s have a look at why this might be...

x.com

Latest from @mrcunitgambia.bsky.social #StrepA group. Show clinical decision rules developed elsewhere (mostly HIC) have poor performance in Gambia & molecular tests detect far more #StrepA than culture. Given burden of RhD in Africa we urgently need better & affordable tests for #StrepA diagnosis

Evaluating clinical decision rules and rapid diagnostic tests for the diagnosis of Streptococcus pyogenes pharyngitis in Gambian children: a diagnostic accuracy study

Accurate diagnosis of Streptococcus pyogenes (S. pyogenes) pharyngitis is imperative in high rheumatic heart disease-burden countries. We aimed to assess the diagnostic accuracy of two rapid diagnosti...

journalofinfection.com

RSV and pneumococcus demonstrate close interaction in epidemiological studies but which is 🐥 and which is 🥚. This study by our group is designed to find out... #idsky #medsky journals.plos.org/plosone/arti...

Understanding the interaction of upper respiratory tract infection with respiratory syncytial virus and Streptococcus pneumoniae using a human challenge model: a multicenter, randomized controlled stu...

Background Streptococcus pneumoniae (pneumococcus) and respiratory syncytial virus (RSV) are major causes of respiratory infections globally. Viral and bacterial co-infections are commonly observed in...

journals.plos.org