Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!

The Francis Crick Institute@crick.ac.uk · 7mo ago

Researchers at the Crick have uncovered how certain proteins that become exposed on dying tumour cells can be detected by the immune system, alerting it to the cancer’s presence and prompting an immune response. www.crick.ac.uk/news/2025-12...

Day 24 of making proteins for #ArtAdventCalendar The nuclear pore complex is a huge pore made of hundreds of proteins, that allows the flow of nucleic acids and proteins between the nucleus and cytoplasm. It also looks like a wreath! Merry Christmas! More projects: e-nox.net/portfolio/ #SciArt

We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

bioRxivpreprint@biorxivpreprint.bsky.social · 8mo ago

Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1

My "News & views" was published today @natmethods.nature.com Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left... www.nature.com/articles/s41...

Targeted RNA-binding protein degradation to improve mRNA live imaging in animal cells - Nature Methods

The gold standard system for mRNA imaging in live cells just got upgraded by being degraded. This development improves signal-to-noise ratios and may lead to a better understanding of mRNA transport a...

nature.com

I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...

Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses

This study dissects the individual contributions of the different components of mRNA vaccines to immune responses. Nucleoside-modified mRNA promotes the production of type I interferons that act on de...

cell.com

How does a macrophage decide to eat or simply nibble? Check out our latest paper! You can also read this nice review. Congrats Caitlin for leading this amazing work! www.nature.com/articles/s41... www.nature.com/articles/s41...

Target cell cortical tension regulates macrophage trogocytosis - Nature Cell Biology

Cornell et al. show that target cells with low cortical tension induce macrophages to preferentially trogocytose, or engulf in small fragments, whereas target cells with high cortical tension tend tow...

nature.com

Day 6 of making proteins for #ArtAdventCalendar This is a "nanodisc", which is a tiny section of lipid membrane, just big enough to hold a single membrane-bound protein, and holds the structure stable enough to probe its structure More projects: e-nox.net/portfolio/ #SciArt

I have a PhD position available with start date September 2026 at the University of Manchester. Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes Due to funding requirements, this position is for UK home students only. www.findaphd.com/phds/project...

Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester on FindAPhD.com

PhD Project - Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester, listed on FindAPhD.com

findaphd.com

Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II: www.biorxiv.org/content/10.6...

Stalling of elongating Pol II triggers Ser7 phosphorylation in trans to drive transcription recovery

DNA is scattered with obstacles that stall RNA polymerase II (Pol II) and block the production of full-length transcripts. Two mechanisms are known to resolve stalled Pol II: transcription-coupled nuc...

biorxiv.org

🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research

Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research

The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...

research.pasteur.fr

Time for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments? Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation doi.org/10.64898/202...

The EMBO Gold Medal 2025 was awarded to Tanmay Bharat and David Bikard: https://www.embo.org/press-releases/embo-gold-medal-2025-awarded-to-tanmay-bharat-and-david-bikard/ 🧪 At #CellBio2025, the EMBO Gold Medal was handed over to David Bikard in recognition of his pioneering work on #GeneEditing.

Some archaea—an ancient group of microorganisms—have an entirely novel genetic code, according to a new study in Science. The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. https://scim.ag/4omApQ7

An archaeal genetic code with all TAG codons as pyrrolysine

Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...

scim.ag

Day 5 of making proteins for #ArtAdventCalendar Today it's HLA-A2, which is critical for the immune system. They present fragments of intra-cellular proteins to CD8+ T cells, which can initiate a targeted immune response. More projects: e-nox.net/portfolio/ #SciArt

BBC News - Top UK scientist says research visa restrictions endanger economy www.bbc.com/news/article...

Top UK scientist says research visa restrictions endanger economy

Prof Sir Paul Nurse says the UK is "shooting itself in the foot" with its visa system for researchers.

bbc.com

Check out the latest paper from Leo James and William McEwan which explains the science behind LMB spin out TRIMTECH Therapeutic's TRIMTAC® degraders ⤵️

TRIMTECH Therapeutics@trimtechtx.bsky.social · 8mo ago

Our academic co-founders have published in Nature Communications - detailing the science behind TRIMTECH’s TRIMTAC® degraders. Congrats to Will, Leo, Dean, Jonathan, and all collaborators advancing state-selective protein degradation: www.nature.com/articles/s41...

🧬 CRN Team De Camilli found that BLTP3A/UHRF1BP1 binds VAMP7 vesicles to lysosomes and activates the CASM pathway after lysosome damage. This drives mATG8 recruitment and helps restore lysosome integrity. 🔗 Check out the full #publication to read more about their findings: bit.ly/4o27nF0

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...

Happy to share our newest preprint on antigen presentation of Mtb-derived peptides on MHC-I: www.biorxiv.org/cgi/content/... This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070

GPR34 is a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells @jem.org rupress.org/jem/article/...

An authoritative review on phagosome immunobiology by David Underhill and Kai Li. Highly recommend for anyone interested in innate immunity, antigen presentation, infection and host defense. @cedarssinai.bsky.social rdcu.be/eNIFY

Phagocytosis: a process that shapes immune responses to engulfed meals

Nature Reviews Immunology - In this Review, Li and Underhill discuss recent advances in understanding the process of phagocytosis. The authors highlight how phagocytosis is integral for innate...

rdcu.be

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...

Delighted that our latest paper is out @jem.org. An intriguing study led by Ana Cardoso exploring the role of DNGR-1 in mouse dendritic cell precursors.

Journal of Experimental Medicine@jem.org · last yr.

Cardoso et al. @reisesousalab.bsky.social show that DNGR-1–deficient pre-cDCs display cell-intrinsic alterations in their ability to colonize peripheral organs. Their findings highlight an unexpected role for innate immune receptors in regulating cDCpoiesis. rupress.org/jem/article/...

Looking forward to meeting PFP enthusiasts at the Prato conference on Pore Forming Proteins in June! ⏰ Early Bird Registration deadline - May 16th ⏰ www.pratopores.org/speakers #PFPsky

At last, direct demonstration that tapasin dependent MHC-I molecules experience greater tapasin filtering, resulting in less diverse MHC-I immunopeptidomes that are enriched in high affinity peptide-MHC-I complexes. Well done Andy and Rachel! links.email.frontiersin.org/ls/click?upn...

Frontiers | Evidence of focusing the MHC class I immunopeptidome by tapasin

Major Histocompatibility Complex class I (MHC-I) molecules bind and present peptides to cytotoxic T cells, protecting against pathogens and cancer. MHC-I is ...

links.email.frontiersin.org

Wow! Amazing response in the first few days of registration opening for www.emds2025.com Be sure to register early to avoid disappointment. 🚨 Abstract deadline is FRIDAY 30th MAY (Sneak peak of @profandrewmac.bsky.social rehearsing for the 'Scotland Experience' social.)

a group of people wearing kilts are dancing in front of a sign that says dairy

ALT: a group of people wearing kilts are dancing in front of a sign that says dairy

media.tenor.com

@emds2025.bsky.social · last yr.

🚨 REGISTRATION NOW OPEN!!! Head to www.emds2025.com to register and submit your abstracts. Full programme is now available. NB: Spaces are limited, so don't delay, register today! @britsocimm.bsky.social @efis-immunology.bsky.social @societymucosalimm.bsky.social @natrevimmunol.nature.com

👉 When splenic metallophilic marginal zone macrophages do antigen cross-presentation equally well as conventional DC1. Congrats to the team of Peter van Endert from @inem-necker.bsky.social for this work published in @cp-immunity.bsky.social www.cell.com/immunity/abs...

Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors

Metallophilic marginal zone macrophages are positioned strategically within the spleen to process internalized blood-borne materials. Mauvais et al. find that these CD169+ macrophages cross-prime CD8+...

cell.com

Thank you to organisers Philippe Bousso, Gillian Griffiths @griffithslab.bsky.social , Milka Sarris & Michael Sixt, and everyone who joined us for our 'Immune Cell Interactions in Development, Homeostasis and Immunity' Workshop. biologists.com/workshops

Our work on K63-polyubiquitin in membrane trafficking is out! Check out how we use a high affinity and specific sensor for K63-polyUb to identify K63-polyubiquitylated plasma membrane proteins in clusters of vesicles containing ATG9A. Link: www.molbiolcell.org/doi/10.1091/...

Trafficking of K63-polyubiquitin modified membrane proteins in a macroautophagy-independent pathway is linked to ATG9A | Molecular Biology of the Cell

Cytoplasmic K63-linked polyubiquitin signals have well-established roles in endocytosis and selective autophagy. However, how these signals help to direct different cargos to different intracellular t...

molbiolcell.org