Andreas Ingham
@andreasingham.bsky.social
Postdoctoral researcher at the Mailand lab. Interested in histone transcription, but also follow any climbing-related content
New online: A proteome-wide dependency map of protein interaction motifs
A proteome-wide dependency map of protein interaction motifs
Nature Structural & Molecular Biology, Published online: 06 March 2026; doi:10.1038/s41594-026-01762-2Ambjørn and Meeusen et al. functionally characterize all reported and a comprehensive set of predicted short linear motifs (SLiMs) using base-editing screens, identifying 450 reported and 264 predicted SLiMs required for normal cell proliferation.
dlvr.it
"Evolutionarily conserved regulation and functions of H1 linker histones in development" by Lu Wang & colleagues "Collectively, this overview positions H1 and its master regulator CRAMP1 as important players in chromatin organization..." FREE till March 27th at authors.elsevier.com/a/1mZUI_3rsx...
Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇
Susi Bantele@sbantele.bsky.social · 9mo ago𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
What specific targets & roles are there for all distinct polyubiquitin chain types? Niels Mailand, Robert Shearer et al profile a panel of #ubiquitin replacement cell lines, implicating K29 chains in chromatin regulation via SUV39H1 destabilization www.embopress.org/doi/full/10....
Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...
DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis
DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...
biorxiv.org
It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...
Linker histone expression is uniquely controlled by a specific pathway, which can be manipulated to increase TOP2i sensitivity! Proud to share first authorship on our story now out in @cp-molcell.bsky.social. www.cell.com/molecular-ce...
CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance
Ingham et al. identify a dedicated H1 linker histone biogenesis pathway in human cells, driven by the protein CRAMP1 that functions as an H1 transcription factor. They demonstrate that defective CRAMP...
cell.com
Online Now: CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance Online now:
CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance
Ingham et al. identify a dedicated H1 linker histone biogenesis pathway in human cells, driven by the protein CRAMP1 that functions as an H1 transcription factor. They demonstrate that defective CRAMP1-dependent H1 synthesis induces excessive demand for topoisomerase II activity in low-accessibility chromatin states, thereby increasing sensitivity to TOP2 inhibitors.
dlvr.it
