Nice summary of our work from our communications office: www.umu.se/en/news/new-...
New study maps how gut bacteria shape each other's growth.
Large-scale mapping reveals the hidden interactions that shape gut microbial life.
umu.se
André Mateus
@andrenmateus.bsky.social
Assistant professor at Umeå University and Team leader at the Laboratory for Molecular Infection Medicine Sweden (MIMS) Follow also lab account: @mateuslab.com Alumnus at @uu.se and at the @EMBL.org (@savitski-lab.bsky.social and @typaslab.bsky.social)
Great to see our paper on mosquito carb-binding proteins out now 🦟🦟🦟 We solved structures of lectins from the yellow fever mosquito, revealing a shared conserved dimer architecture, with AF predictions suggesting hundreds of potential heterodimers too. febs.onlinelibrary.wiley.com/doi/epdf/10....
Super happy to see the final version of our paper out now 🎉🎉🎉 www.science.org/doi/10.1126/... Proud of PhD student Rupesh @rupeshjayachandran.bsky.social and postdoc Erwan for doing really nice work on this 😊
Open and closed forms of assembled henipavirus nucleoprotein suggest structural basis of genome access
Henipavirus nucleoprotein assemblies exist in different conformations, indicating temporary release of genome for RNA synthesis.
science.org
Max Renner@maxrenner.bsky.social · 10mo agoOur new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇
New preprint from the lab! We developed a new tool to identify prokaryotic species (down to the strain level) directly from mass spectrometry-based bottom up proteomics data. #teammassspec #microsky www.biorxiv.org/content/10.6...
biorxiv.org
So happy to have been part of the @savitski-lab.bsky.social! I also want the sweater!
Savitski Lab@savitski-lab.bsky.social · 6mo ago10 years and still standing strong @EMBL 🍾💪 Huge thanks to all members, alumni, supporters & colleagues who made it possible. Here’s to the next decade! 🙏
Billions of bacteria are already known and play a crucial role in our #health – but there is also an almost invisible neighboring group: the #Archaea. These are ancient microorganisms whose function in the human body remains something of a mystery @umeauniversitet.bsky.social tinyurl.com/yhr9yjsm
The secrets of Archaea could provide new keys to our health | Knut and Alice Wallenberg Foundation
Our intestines teem with life. Billions of bacteria are already known and play a crucial role in our health – but there is also an almost invisible neighboring group: the Archaea. These are ancient mi...
tinyurl.com
Our new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇
Mosquitoes like Aedes aegypti spread viruses that cause major global diseases. We decided to have a closer look at a family of mosquito carbohydrate-binding proteins involved in infecting these vector species. We found some unexpected things 😁 Preprint out now 🦟🦟🦟 www.biorxiv.org/content/10.6...
ICYMI during the holidays. I am really proud of Bolor's efforts and the first work coming out of the lab! Read it here: www.biorxiv.org/content/10.6...
Systematic profiling of growth interactions in human gut microbiome species
Microbial interactions shape the composition and stability of the human gut microbiome. Yet, the molecular mechanisms underlying these relationships remain poorly understood. Here, we systematically p...
biorxiv.org
Mateus lab@mateuslab.com · 8mo agoNew preprint from the lab is out! 🥳 We systematically profiled all pairwise growth interactions between 36 representative human gut microbiome strains, and delved deeper into the molecular mechanisms behind specific growth interactions. www.biorxiv.org/content/10.6... 👇
📣New preprint with @rberntsson.bsky.social👇We overturn the long-standing view that Gram-positive bacteria lack conjugative pili! We identify pili-forming proteins in a wide range of bacteria and show they're essential for the spread of #antibioticresistance #AMR 🧵1/6 www.biorxiv.org/content/10.6...
Pili are essential for conjugation also in many Gram-positive bacteria
Type IV secretion systems (T4SS) enable the spread of antibiotic resistance and other virulence factors. In Gram-positive bacteria, T4SSs have long been thought to lack VirB2-like proteins that form c...
biorxiv.org
New paper from the lab! Led by Patrick Müller: we show that non-antibiotic compounds — but not macrolide antibiotics — can induce an efflux pump that protects Bacteroidaceae from macrolides. A neat twist on drug–microbe interactions... www.tandfonline.com/doi/full/10....
Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏 www.biorxiv.org/content/10.6...
Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling
Protein glycosylation regulates essential cellular processes including protein folding, stability, and cell-cell interactions; however, how aberrant glycosylation impacts protein function and interact...
biorxiv.org
Thrilled to share that our study on how the pcnB gene sustains Shigella virulence is now published in PLOS Pathogens: journals.plos.org/plospathogen... In short: pcnB ➝increased virulence-plasmid replication ➝ elevated T3SS expression ➝ enhanced invasion/spread within the intestinal epithelium.
The pcnB gene sustains Shigella flexneri virulence
Author summary Bacterial infections represent a major global threat. Understanding the genetic determinants promoting infections is crucial to overcome this threat. Shigella is an intracellular bacter...
journals.plos.org
Finally out! A small screen helps understand a little more about how E. coli regulates major transporters, and reveals how caffeine induces phenotypical antibiotic resistance. Huge thanks to collab @andrenmateus.bsky.social (Umeå) and Christian L. Müller (Munich)! journals.plos.org/plosbiology/...
Systematic screen uncovers regulator contributions to chemical cues in Escherichia coli
Transport machineries are crucial for antibiotic resistance, but their regulation by external cues is poorly understood. This study identifies environmental chemicals that regulate transporter transcr...
journals.plos.org
New preprint out: www.biorxiv.org/content/10.1... We followed up on our recent Nature Genetics paper mapping Shigella colonization in intestinal organoids with a deep dive into one of the screen hits: pcnB. #Shigella #virulence #microsky
biorxiv.org
Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization. Out @natgenet.nature.com: rdcu.be/eqGgf
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen
Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...
rdcu.be
Do we really know the antibiotics that we already have? Check out our story on 60y old drug nitroxoline and its new tricks! @goetheuni.bsky.social @embl.org www.nature.com/articles/s41... + great piece from the synchrotron @esrf.fr where we chased nx effects on metals www.esrf.fr/home/news/ge...
nature.com
Looking forward to speaking in this webinar series next Wednesday.
Front Line Genomics@flgenomics.bsky.social · last yr.The future of #DrugDiscovery lies in the untapped #proteome. Join our experts in our latest 2-part webinar series as they reveal how cutting-edge #proteomics is unlocking novel targets. 🕒 Sign up now: hubs.ly/Q03hBRhj0 Our lineup includes @andrenmateus.bsky.social, @mads-chem.bsky.social and more!
So happy to see the first paper on research from the lab out! Just a review for now, but it gives an idea of the avenues we are exploring.
Mateus lab@mateuslab.com · last yr.As we start exploring this unique system of O-glycosylation in Bacteroidota species, we have reviewed the current state-of-the-art and offer some ideas on the directions we want to take. #glycotime doi.org/10.1002/2211...
We have a PhD student position open in the context of the ENDAMR doctoral network. Deadline is 31/May. Apply here: umu.varbi.com/en/what:job/...
PhD position in Chemistry, with a specialization in biochemistry
The Department of Chemistry is opening a PhD position in Chemistry with a specialization in biochemistry. The thesis project will focus on drug resistance mechanisms in microbiome species, and is part
umu.varbi.com
Looking forward to sharing with this community what our lab is doing
IceLab@icelabumu.bsky.social · 2y agoSeminar in IceLab today! New IceLab affiliated researcher Andre Mateus will talk about functional proteomics of human gut microbiome species at 14:00. https://www.umu.se/en/events/icelab-seminar-with-andre-mateus_12030109/