It’s finally here! 🎉 Delayed a bit by the classic post-PhD lab change, but very happy to see this work published. Thank you @lionelguy.bsky.social and @sellinlab.bsky.social 😄

Cell Reports Methods@cp-cellrepmethods.bsky.social · 7mo ago

High-efficiency transfection of Acanthamoeba castellanii using a cationic polymer

Most updates from our lab nowadays found at LinkedIn: www.linkedin.com/in/mikael-se...

Thrilled to share that our study on how the pcnB gene sustains Shigella virulence is now published in PLOS Pathogens: journals.plos.org/plospathogen... In short: pcnB ➝increased virulence-plasmid replication ➝ elevated T3SS expression ➝ enhanced invasion/spread within the intestinal epithelium.

The pcnB gene sustains Shigella flexneri virulence

Author summary Bacterial infections represent a major global threat. Understanding the genetic determinants promoting infections is crucial to overcome this threat. Shigella is an intracellular bacter...

journals.plos.org

Organoider, miniatyrorgan som odlas från mänskliga stamceller, är mycket användbara i forskning. I framtiden kommer de ha en stor betydelse även inom transplantationsvården. #Organoid #UppsalaUniversitet #Forskning

Mast cell subsets respond uniquely to Salmonella infection. Read all about it in our latest paper in EJI. Another chapter in our deciphering of mast cell interactions with enterobacteria, driven by Chris von Beek. onlinelibrary.wiley.com/doi/10.1002/...

Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria

Mast cell phenotypic features influence anti-bacterial response. Connective tissue-like mast cells sense Salmonella through combined Toll-like-receptor (TLR) signaling and recognition of Type-III-sec....

onlinelibrary.wiley.com

Such a rewarding collab it has been with our colleagues at #Novavax to dissect the MoA of their potent Matrix-M adjuvant. This project has really put the imaging skills of @erixoneriksson.bsky.social to the test. The fruits of this joint labour out now in NPJ Vaccines www.nature.com/articles/s41...

Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization - npj Vaccines

npj Vaccines - Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization

nature.com

Alert! The abstract deadline for the Microbial Pathogenesis & Host Response meeting has been extended to July 7 meetings.cshl.edu/meetings.asp...

Microbial Pathogenesis & Host Response

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu

Thanks for the invitation to share our work and to see the wide span of efforts on understanding and controlling #salmonella presented at this weeks #I3S congress, set in beautiful St Malo. i3scongress.innozh.fr

📢ONLINE @natgenet.nature.com 📰A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen. By @mldm.bsky.social, @lbarquist.bsky.social, Mikael E. Sellin and colleagues. ⬇️ www.nature.com/articles/s41...

A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen - Nature Genetics

A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for epithelial colonization.

nature.com

@mldm.bsky.social showcasing our recently published Shigella gut organoid infection screen at #EESMicrobiology this week.

Maria Letizia Di Martino@mldm.bsky.social · last yr.

Excited to be at #EESMicrobiology this week presenting our latest work on #Shigella gut #organoid infection screen from our recent Nature Genetics paper (see below)! Stop by poster 109 or just look for me, happy to chat and connect! #Microbiology #Shigella #Organoids #TraDIS

The abstract submission deadline for Understanding and predicting microbial evolutionary dynamics 2025 is soon approaching! Make sure to submit by 23:59 BST on 7 July 2025. microb.io/Abstracts #MicroEvo25

New preprint out: www.biorxiv.org/content/10.1... We followed up on our recent Nature Genetics paper mapping Shigella colonization in intestinal organoids with a deep dive into one of the screen hits: pcnB. #Shigella #virulence #microsky

Thanks @sydneylmiles.bsky.social and @sergemostowylab.bsky.social for writing such a sharp and thoughtful editorial, which covers all the main points and potential caveats of our study published yesterday. www.nature.com/articles/s41...

Organoid models advance dysentery control - Nature Genetics

Shigella is a major human pathogen with a stark lack of pipelines linking genome content to clinical pathogenesis. An innovative study using large-scale organoid models, combined with genome-wide muta...

nature.com

Thanks @scilifelab.se for the highlight of our recently published study @natgenet.nature.com. Link to the full paper here: rdcu.be/eqGgf

SciLifeLab@scilifelab.se · last yr.

“we used mini organs, specifically mini-intestines, and infected them with a dangerous bacterium called Shigella” says @mldm.bsky.social‬ @sellinlab.bsky.social‬ (SciLifeLab & @uu.se) shows that cultured mini-organs can uncover how pathogens cause disease youtu.be/xG_66ZGd_fk

Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization. Out @natgenet.nature.com: rdcu.be/eqGgf

A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen

Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...

rdcu.be

I enjoyed this NPR story but thought it was a bit unclear regarding the origin of the name "Salmonella" and who should be credited with its discovery.

NPR@npr.org · last yr.

Despite its fishy name, the bacteria salmonella has no connection to the underwater creature.

New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...

Just a few spots remaining for the GRC Salmonella Biology and Pathogenesis meeting to be held in August. The final program is now online. www.grc.org/salmonella-b... Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......

Planning to apply for #research #funding from the ERC? From the next application rounds, expect changes to the: • proposal structure • evaluation process • extra funding you can request • eligibility for Starting & Consolidator #Grants (from 2027) More 👇 europa.eu/!RPHWvv

Changes to the 2026 and 2027 Work Programmes

With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...

europa.eu

Out now @mbio.bsky.social !: We provide a time-resolved map comparing #Salmonella and #Shigella epithelial colonization strategies in human #enteroids and #colonoids. Connecting the dots among decades of molecular findings reg. underlying virulence factors. journals.asm.org/doi/10.1128/...

Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids | mBio

Pathogenic bacteria employ partially overlapping sets of virulence factor functions to colonize host epithelia but can differ markedly in their pathogenesis and disease kinetics. This work combines ba...

journals.asm.org

The LeibundGut-lab at the @mrccmm.bsky.social, in collaboration with @neil-gow.bsky.social, recruits two postdocs to study the skin commensal yeast Malassezia in atopic dermatitis #fungalrecognition and #fungalimmunology jobs.exeter.ac.uk/hrpr_webrecr... jobs.exeter.ac.uk/hrpr_webrecr...

Great meeting coming up next May www.keystonesymposia.org/conferences/...

#EESInfection was very inspiring and enriching! Thanks for all new connections and for the opportunity to present our soon to be published story on TraDIShigella during infection of human intestinal organoids! Stay tuned to read the full story!

EMBL Events@events.embl.org · last yr.

And it’s a wrap on #EESInfection! ✨🦠 Huge thanks to all participants, speakers, and organisers who made it a success. Can’t wait for next time! 🏅👏 Congrats to our 5 poster prize winners for their fantastic work! Stay updated ➡️ embl.org/events/

The 23rd ESCMID Summer School is soon approaching! Claim your spot before it's too late! lnkd.in/dNJ67B6B 🛎️ Registration deadline extended to next week, 04 June 2025! 🗓️ 29 June - 05 July ☀️ 🌍 University College Dublin, Ireland 🍀 #IDSky #MedSky #clinmicro

Only 328 days to go! We're very busy behind the scenes getting thigns ready for the meeting! In the meantime you can add your email address for updates here: coming-soon.embo.org/w26-04

Congrats to our newly baked Dr. Christopher von Beek, who defended his thesis on #Mastcells and #bacterial #infection in stride. Hooray! Thanks a lot to faculty opponent Jean Marshall and committee members Sanna Koskiniemi, Cecilia Andersson and Stefan Roos for the high-level sparring.

Was great fun to have the emminent @lbarquist.bsky.social visit for the @scilifelab.se The Svedberg seminar this week. Few can explain computation and statistics so that even wetlab biologists get it, but here is one: www.utm.utoronto.ca/biology/peop... www.helmholtz-hiri.de/en/research/...

Been a fun and fruitful industry collab with R&D of @novavax.bsky.social, teasing apart the mechanism of action of the MatrixM adjuvans. With some superb live-cell imaging by our @erixoneriksson.bsky.social together with Behdad Zarnegar. Here the resulting preprint: www.biorxiv.org/content/10.1...

Matrix-M® adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization

Matrix-M® adjuvant, containing saponins, delivers a potent adjuvant effect and good safety profile. Given that Matrix-M is composed of Matrix-A and Matrix-C particles, comprising different saponin fra...

biorxiv.org

Dear mucosal immunologists! Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open. Register and see you this July in Aachen! 👇🏼 emig2025.de @petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social

Three SciLifeLab group leaders are part this episode in "Om Vetenskap", a Swedish science podcast made by @strategiska.bsky.social. 🧪 Listen in Swedish here: strategiska.se/pressmeddela... The group leaders are: Anna Falk (@lundsuniversitet.bsky.social) Maria Tenje (@uu.se) Mikael Sellin (UU)

Ny säsong Om Vetenskap: Odlade organ - framtidens reservdelar? - Stiftelsen för strategisk forskning

Nu är den återigen här – SSF:s podd Om Vetenskap! Årets första avsnitt handlar Om: Odlade …

strategiska.se