A big day for ancestry-specific polygenic risk scores in the PGS Catalog, a phenome-wide atlas of scores for 241 traits (1501 PGS)! Check it out 🔗: www.pgscatalog.org/publication/...!

Nature@nature.com · 10mo ago

Nature research paper: Population-specific polygenic risk scores for people of Han Chinese ancestry go.nature.com/3WCMp4n

The new v2.3.0 release of pgsc_calc makes our calculator tool fully compatible with scores from the updated @omicspred.bsky.social resource (www.omicspred.org)! Stay tuned for future updates to v3 that improve WGS compatibility next. Github 🔗: github.com/PGScatalog/p...

Release v2.3.0 · PGScatalog/pgsc_calc

Changelog Improvements Add partial OmicsPred support by @smlmbrt in #498 Bug fixes Fix compatibility with strict syntax in Nextflow v26 Fix quarto report generation with recent Fusion filesystem...

github.com

Sam Lambert@iamslambert.bsky.social · 3mo ago

Interested in applying multi-omics imputation or TWAS/PWAS approaches to your data? Frustrated by the models being spread across multiple resources? Enter OmicsPred: a centralised resource for genetic prediction of multi-omic traits! 🔗 : www.omicspred.org 📃 : www.medrxiv.org/content/10.6...

Lots of exciting new scores in our latest release! Including: - Multiple metabolic PRS: www.pgscatalog.org/publication/... - First score for Eosinophilic Esophagitis: www.pgscatalog.org/score/PGS012... & much more! Share your data at www.pgscatalog.org/submit!

Wish it was easier to calculate PGS in trusted research environments (TRE) like DNAnexus or the All of Us workbench? Us to! We've been hard at work on a new version of pgsc_calc to make it more scalable in those TREs! Introducing pgsc_calc v3.0.0-alpha.1: pgsc-calc.readthedocs.io/en/v3-alpha.1/

Another month and lots of new & useful data added to www.PGSCatalog.org! Including new multi-ancestry insulin resistance scores, a score tailored for heart failure in East Asian individuals & more!

🚨 Countdown to #ASHG25: Predicted Effector Gene standard is coming! 🚨 Join us and be part of the conversation! 📌 Poster Oct 16 | 2:30–4:30 | Poster Hall 🗓️ Session Oct 17 | 11:45–1:15 | Room 259A Learn more: kpnashg2025.wordpress.com/pegs-workshop/

PEGs Workshop

Friday, October 17th | 11:45AM – 1:15PM | Convention Center room 259A The meeting will open with an introduction (Noel Burtt), include a recap of the landscape analysis (Laura Harris), presentation…

kpnashg2025.wordpress.com

At #ASHG25 and want to meet members of the GWAS Catalog & PGS Catalog teams? Stop by the @impc-phenotypes.bsky.social booth 1420 where we're helping out!

Some recent data: - First scores for frailty measurements (@isyfoote.bsky.social & @andrewgrotzinger.bsky.social‬): www.pgscatalog.org/publication/... - Comprehensive comparison of type 2 diabetes PGS in Qatari Biobank: www.pgscatalog.org/publication/... Share PGS 👉 www.PGSCatalog.org/submit!

Check out the latest and most powerful polygenic scores for body mass index and obesity from @roelofajsmit.bsky.social et al. in the PGS Catalog: www.pgscatalog.org/publication/.... Thanks to the authors for submitting the data pre-publication! Submission information @ www.pgscatalog.org/submit

Nature Portfolio@natureportfolio.nature.com · last yr.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood, according to a paper in Nature Medicine. go.nature.com/3H0sA2N #medsky 🧪

At #ISMB2025 in Liverpool? Interested in polygenic scores? Ben Wingfield will be back at his poster this afternoon at 4 PM (B507 / TransMed) to discuss all things pgsc_calc - our portable, scalable Nextflow workflow, designed for PGS calculation at scale in TREs! Go say hello!

Check out this PRS (www.pgscatalog.org/publication/...) and more in the latest PGS Catalog data release! Thanks to @pnatarajanmd.bsky.social & co for submitting their scores! See www.pgscatalog.org/submit for information about how to share your work!

Pradeep Natarajan@pnatarajanmd.bsky.social · last yr.

Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio

Great to see so many PGS Catalog IDs in the wild on posters at #ESHG2025, #OpenData and #FAIRdata for all! Users and submitters are the lifeblood of the resource, get in touch if you ever have feedback or suggestions for improvement!

Great fun sharing the @pgscatalog.bsky.social at the pre- #ESHG25 course on open-source genomics resources. Thanks to Juliana Cerqueira and Inga Prokopenko for the invite! Looking forward to the rest of the conference!

Interested in the results of the BARCODE PRS-guided prostate cancer screening study last month in @nejm.org? Just added to the Catalog is the PRS that was used in the cohort: www.pgscatalog.org/score/PGS005.... This and more in the latest release!

The Institute of Cancer Research@icr.ac.uk · last yr.

BREAKING NEWS: #ProstateCancer spit test is better for men with high genetic risk than the standard PSA blood test. The results from the ICR's BARCODE 1 trial are published in @nejm.org More here ⬇️ icr.ac.uk/about-us/icr-news/detail/simple-spit-test-could-finally-turn-the-tide-on-prostate-cancer

🚨 EBI has just lunched a new portal to calculate genetic scores from individual-level genetic data. Check it out 👇. It is very cool! geneticscores.org It is linked with the @pgscatalog.bsky.social This was supported by INTERVENE

Thanks to @mglevin.bsky.social for sharing this new heart failure PRS from @naturegenet.bsky.social, 🔗: www.pgscatalog.org/score/PGS005.... This and more in the latest release, submit your scores at www.pgscatalog.org/submit!

Michael Levin@mglevin.bsky.social · last yr.

Excited to see this published: rdcu.be/egHer Common- and rare-variant genetic analyses of heart failure in >2 million individuals 🔘 Dozens of new common variant loci 🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes 🔘 A PRS modifies penetrance of TTNtv

Interested in calculating polygenic scores in the All Of Us workbench? Like those from @pgscatalog.bsky.social? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/ho.... Very much work-in-progress, optimisations incoming!

Discover data from our latest release: - New PGS for atrial fibrillation (buff.ly/E1TkmKv) - PGS optimised for East Asian ancestry in cancer (buff.ly/gLkYKVo) and 10 other common diseases (buff.ly/nG7rOIq) Find out how to submit your data here: buff.ly/nJCjUMr

We're pleased to announce our latest free online tutorial! This is for anyone who wants to find out more about polygenic scores and how to explore the data in the PGS Catalog: www.ebi.ac.uk/training/onl... Produced in collaboration with @pgscatalog.bsky.social

📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!

Now available in the PGS Catalog 🔗: www.pgscatalog.org/publication/...! Thanks to authors like Sean for submitting the data directly, find out how to submit your data at pgscatalog.org/submit

Sean@seanlzheng.bsky.social · last yr.

🚨Our double header on genetics of hypertrophic #cardiomyopathy out today in @naturegenet.bsky.social 🧬 📍GWAS www.nature.com/articles/s41... 📍polygenic scores www.nature.com/articles/s41... A consortia effort by @jamesware.bsky.social Hugh Watkins @conniebezzina.bsky.social Rafik Tadros & Anuj Goel

Welcome @omicspred.bsky.social (www.omicspred.org) to 🦋! OmicsPred focuses on curating genetic scores for omics-traits (genes, proteins, metabolites) to power large-scale association analyses. Check it out!

OmicsPred@omicspred.bsky.social · last yr.

Introducing a major upgrade to OmicsPred platform (www.omicspred.org) — a resource to enhance the accessibility and usability of genetic scores for multi-omic traits and their phenotypic associations. (1/N)

Are you going to #FOG2025? Meet us to learn about the integration of processes with PGSCatalog or metadata generation and harmonisation pipelines for #SumStats. Share your data bit.ly/38rNSjx #openaccess

Let's start with introductions! The PGS Catalog is an open database of polygenic scores and the relevant metadata required for accurate application and evaluation. Everything is on our website www.PGSCatalog.org, and our newest publication describes how far we've come: rdcu.be/d1vTG since 2019!

If you're interested in the PGS Catalog Calculator we're hosting a free training webinar @ebi.embl.org on December 4th: www.ebi.ac.uk/training/eve... (registration required). Come along, or catch up with the recording after! cc @iamslambert.bsky.social

The Polygenic Score Catalog@pgscatalog.bsky.social · 2y ago

The Catalog isn't just a knowledgebase and source of polygenic scores, we also provide open-soruce tools to make PGS calculation easier and more reproducible! You can find our pgsc_calc tool on github (github.com/PGScatalog/p...) with extensive documentation (pgsc-calc.readthedocs.io/en/latest/).

Let's start with introductions! The PGS Catalog is an open database of polygenic scores and the relevant metadata required for accurate application and evaluation. Everything is on our website www.PGSCatalog.org, and our newest publication describes how far we've come: rdcu.be/d1vTG since 2019!