A roadmap for conducting more inclusive research on brain resilience in ageing and dementia — a Roadmap article by M. Natasha Rajah, Roger A. Dixon, Gillian Einstein, Yaakov Stern & The Brain Resilience and Diversity in Aging and Dementia Collaboratory www.nature.com/articles/s41...

A roadmap for conducting more inclusive research on brain resilience in ageing and dementia - Nature Reviews Neuroscience

Guidance is lacking on how to best integrate sex, gender and social and structural determinants of health into neuroscience research on brain resilience in ageing and dementia. In this Roadmap article...

nature.com

Out now in Nature Communications! 🧬🖥️ An Open Targets team developed a metric for the novelty of a target in the context of a disease, according to current available knowledge. This allows drug discovery scientists to easily identify potentially novel targets www.nature.com/articles/s41...

Temporal trends in evidence supporting novel drug target discovery - Nature Communications

Here the authors implement a comprehensive timestamping across millions of pieces of biomedical evidence supporting target–disease associations in the Open Targets Platform and analyse trends in evide...

nature.com

New online! The Nottingham consensus on dementia risk reduction policy: recommendations from a modified Delphi process

The Nottingham consensus on dementia risk reduction policy: recommendations from a modified Delphi process

Nature Reviews Neurology, Published online: 16 January 2026; doi:10.1038/s41582-025-01173-9Translation of evidence about dementia risk into effective public health policy is a challenge. In this Consensus Statement, Demnitz-King and colleagues present 56 policy recommendations for dementia prevention, providing policymakers with a foundation for designing and implementing evidence-based dementia prevention strategies, prioritizing clear communication, targeted intervention and sustained research investment.

dlvr.it

How can policy reduce dementia risk? We convened a panel of experts to develop policy recommendations for dementia risk reduction, refining them through a modified-Delphi process. The final result is the Nottingham consensus, published today in @natrevneurol.nature.com 👇 tinyurl.com/4rsz2yy6

First time on Bsky and first big announcement! I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Our manuscript is here: www.nature.com/articles/s41....

Estimation and mapping of the missing heritability of human phenotypes - Nature

WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...

nature.com

How do GWAS and rare variant burden tests rank gene signals? In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck! 🧬🧪🧵 www.nature.com/articles/s41...

Specificity, length and luck drive gene rankings in association studies - Nature

Genetic association tests prioritize candidate genes based on different criteria.

nature.com

Not all pathogenic variants are in coding regions! 👀 📢 This review highlights Mendelian disease-causing UTR variants, their mechanisms, and implications for clinical interpretation. 🧬 #Mendelian #UTRvariants #ejhg www.nature.com/articles/s41...

The role of untranslated region variants in Mendelian disease: a review - European Journal of Human Genetics

European Journal of Human Genetics - The role of untranslated region variants in Mendelian disease: a review

nature.com

A key (too often ignored) aspect of Alzheimer's research is translation of findings between familial disease, specialist clinics, and general population. In this piece we identify key unanswered research questions and describe a framework for knowledge integration. www.nature.com/articles/s41...

Key questions for the future of amyloid research in dementia: a framework for integrating complex datasets - Molecular Psychiatry

Molecular Psychiatry - Key questions for the future of amyloid research in dementia: a framework for integrating complex datasets

nature.com

I'm looking for a PhD student to do some trailblazing at the frontier of personality genomics and lifespan gene-environment transactions (start Fall 2026)! If you want to work with me: psychology.msu.edu/graduatestud... (PS @drmeltemyucel.bsky.social is taking a student too, in moral psych/dev!)

Super cool study looking at understanding age-dependent impacts on genetic variance!!

Arun Durvasula@arundurvasula.bsky.social · last yr.

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

Some recent data: - First scores for frailty measurements (@isyfoote.bsky.social & @andrewgrotzinger.bsky.social‬): www.pgscatalog.org/publication/... - Comprehensive comparison of type 2 diabetes PGS in Qatari Biobank: www.pgscatalog.org/publication/... Share PGS 👉 www.PGSCatalog.org/submit!

New work in Nature Genetics from IBG members lead by @isyfoote.bsky.social (along with @andrewgrotzinger.bsky.social) examining different measures of frailty using Genomic SEM. Findings reveal six genomic factors with unique biological pathways and clinical correlates. www.nature.com/articles/s41...

Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling - Nature Genetics

Multivariate genome-wide association analyses of the latent genetic architecture of frailty identify one general factor of genetic overlap across all frailty deficits and six factors indexing a shared...

nature.com

What evidence do we have on the Social Determinants of Dementia (SDOD)? Delighted that this scoping review, a year or so in the making, is now published in @alzdemjournals.bsky.social. Expertly led by Anouk Geraets, we identified... doi.org/10.1002/alz.... 1/

Nature research paper: Structural variation in 1,019 diverse humans based on long-read sequencing go.nature.com/3GI9EWC

Structural variation in 1,019 diverse humans based on long-read sequencing - Nature

Intermediate-coverage long-read sequencing in 1,019 diverse humans from the 1000 Genomes Project, representing 26 populations, enables the generation of comprehensive population-scale structural variant catalogues comprising common and rare alleles.

go.nature.com

Differences in physical, social, and sociopolitical factors across the world have resulted in marked disparities in healthy ageing across countries, according to an analysis in Nature Medicine. go.nature.com/3UfJ8GU #medsky 🧪

🚨New preprint is out! How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw. shorturl.at/17snd A thread 🧵👇

Design and model choices shape inference of age-varying genetic effects on complex traits

Understanding how genetic influences on complex traits change with age is a fundamental question in genetic epidemiology. Both cross-sectional (between-subject) and longitudinal (within-subject) appro...

shorturl.at

ICYMI: New online! Translating lifestyle interventions for optimal brain health in Africa

Translating lifestyle interventions for optimal brain health in Africa

Nature Reviews Neurology, Published online: 11 July 2025; doi:10.1038/s41582-025-01104-8This Perspective article explores the efficacy of multimodal lifestyle interventions to tackle the rising incidence of dementia in low- and middle-income countries. The authors discuss a contextual adaptation of the Finnish FINGER trial, Africa-FINGERS, which is pioneering a culturally relevant, multidomain approach to dementia risk reduction for African settings.

bit.ly

In a large-scale proteomic study of biological aging of 11 organs, the biological ages of the brain and immune system emerged as strong predictors of healthspan and longevity, according to a paper in Nature Medicine. go.nature.com/44nLb1M #medsky 🧪

Bell et al. report that multisite chronic pain, unlike single-site, in older adults is linked to faster cognitive decline and increased AD pathology, particularly in APOE-ɛ4 carriers. This supports multisite pain as a risk factor for AD dementia. Read at buff.ly/tXL0Qro @TylerBellPhD

Preprint alert! 🚨 doi.org/10.1101/2025... Our manuscript on Exome sequencing and analysis of 44,028 British South Asians, using @genesandhealth.bsky.social is now available at @medrxivpreprint.bsky.social! We present several great results, and I’m thrilled to highlight the pieces I worked on:

Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity

Genes and Health (G&H) is a biomedical study of adult British-Pakistani and -Bangladeshi research volunteers enriched for autozygosity. We performed whole exome sequencing in 44,028 G&H participants, ...

doi.org

📣📣 Preprint just out from the awesome Xilin Jiang, Yujie Zhao & co! Pleiotropic heritability quantifies the shared genetic variance of common diseases www.medrxiv.org/content/10.1... The overlap of disease aetiologies is surprisingly pervasive... ~50% of common disease heritability is pleiotropic!

External link live! Please share widely :-) WE ARE RECRUITING! 🥳 Are you an epidemiologist with strong quantitative skills and an interest in contributing to exciting research into the genetic architecture of vascular dementia? Come join our friendly and productive team at UCL! shorturl.at/aZ5Ua