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Ann T. Tate

@annttate.bsky.social

Immune system evolution and host- parasite interactions. Associate Prof at Vanderbilt U

29 Posts2187 Follower365 Folgt
Ann T. Tate@annttate.bsky.social · 6mo ago

I think about this constantly, considering that neither my baby nor I have been healthy for more than two days at a time since mid November. It takes a toll, for sure, and we can only hope there is some payoff later.

Charlotte Houldcroft@virologyhouldcroft.bsky.social · 6mo ago

Have you ever wondered why children starting nursery/daycare pick up so many germs? I certainly did, and with a crack team of parent-scientists/clinicians, we set out to answer that question. Is childcare a germ factory or an immune bootcamp? journals.asm.org/doi/10.1128/...

Mark A. Hanson@hansonmark.bsky.social · 9mo ago

Now published as version of record at @elife.bsky.social ! Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️) elifesciences.org/articles/107... shop.vbc.ac.at/vdrc_store/d... #Drosophila #IDsky #SymbioSky #Infection #Immunology

eLife Assessment This work provides one of the first important attempts to look at Drosophila immune responses against bacterial, viral, and fungal pathogens in a way that combines the roles of four major arms in immunity (Imd signaling, Toll signaling, phagocytosis, and melanization) rather than studying them separately. The findings are compelling and the tools provided can be used as they are, or built upon, in various contexts. https://doi.org/10.7554/eLife.107030.3.sa0Figure 1 validating the mutations usedFigure 3 summarising the survival results from a 14-genotype 25-pathogen panel.Tracking of mortality and pathogen growth over time, complemented by Figure 5 (not shown) looking at pathogen load upon death.
Mark A. Hanson@hansonmark.bsky.social · last yr.

Excited to finally announce this work which has been in the pipeline for 5 years: Layers of Immunity. Faustine et al. made a set of immune mutants covering 4 major immune modules in #Drosophila, deleting melanization (ROS), phagocytosis, and both Toll & Imd NF-kB responses. What did we find? 1/n 🧵

Will Ratcliff@wcratcliff.bsky.social · last yr.

Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.

Ann T. Tate@annttate.bsky.social · last yr.

Ever wonder whether older genes contribute to more processes than younger ones, or whether gene duplication might break up pleiotropy over evolutionary time? Does it matter if we're talking about dev. vs. immune genes? Check out our new paper, headed by postdoc Reese Martin: doi.org/10.1093/evle...

Pleiotropy increases with gene age in six model multicellular eukaryotes

Abstract. Fundamental traits of genes, including function, length, and Guanine-Cytosine (GC) content, all vary with gene age. Pleiotropy, where a single ge

doi.org

Rita Strack@ritastrack.bsky.social · last yr.

Sometimes authors summarize their responses to 3-6 major points raised by the reviewers in their resub cover letters or at the top of their rebuttal letters. This is so super helpful to editors, because it brings us right up to speed after not having read the paper/reviews for months. THANKS!!

Joshua Weitz@joshuasweitz.bsky.social · last yr.

Get the word out far and wide. New opportunity from the Simons Foundation in the Eco-Evo space. 2026 Simons Graduate Fellowship in Ecology and Evolution Awards, due July 31, 2025, only for incoming PhD students who plan to start their PhDs in Fall 2026. www.simonsfoundation.org/grant/simons...

Simons Graduate Fellowships in Ecology and Evolution

The purpose of these awards is to provide support for students entering U.S.-based Ph.D. programs with a plan to perform research in ecology and evolution. While we will consider all projects in ecolo...

simonsfoundation.org

Ann T. Tate@annttate.bsky.social · last yr.

If you use AI to write/assist your manuscript reviews, please know that whatever time it saves on your end may well be spent manifold by the authors trying to sort legitimate human criticism from AI nonsense, emailing the journal office about their AI policy and asking for guidance, etc.

Chise@sailorrooscout.bsky.social · last yr.

THIS IS HUGE! TWO Phase I HIV vaccine clinical trials have demonstrated that a stepwise mRNA-based vaccination strategy can SUCCESSFULLY activate AND advance immune responses toward producing broadly neutralizing antibodies (bnAbs), a CRITICAL milestone in HIV prevention. Let’s talk about that! 🧪🧵⬇️

Alondra Nelson@alondra.bsky.social · last yr.

"For me, the answer now lies in refusal, the withdrawal of participation from systems that require dishonesty as the price of belonging." Today I am resigning from the National Science Board and the Library of Congress Scholars Council. I wrote about my decision in TIME. time.com/7285045/resi...

Why I’m Resigning from the NSF and Library of Congress

I cannot participate in systems that require dishonesty as the price of belonging.

time.com

Ann T. Tate@annttate.bsky.social · last yr.

Ever wondered why your favorite immune signaling pathway is regulated by a simple (or complex) set of feedback loops, and how they might have gotten there? Check out our new paper on the evolution of signaling network topology in MBE, headed by postdoc Danial Asgari: doi.org/10.1093/molb...

Evolutionary Studies at Vanderbilt@evolutionvu.bsky.social · last yr.

Some genetic systems resist change... by design. New research from @annttate.bsky.social & Danial Asgari shows how downstream negative feedback loops (NFLs) help cellular systems buffer evolutionary pressures. 🧬🏈 Read the ESI press release: loom.ly/ZKprbCE @vuartsci.bsky.social

Two researchers from the Tate Lab are shown against a football field background, with floating monitors and laptops displaying scientific figures and terminal code. The caption reads: “New research from the Tate Lab explores how downstream negative feedback loops (NFLs) buffer evolutionary pressures—just like a good linebacker holds the line.” The image visually links cell biology and football defense, tying into the theme of the article.
hi, no thanks@hmmvryintrstng.bsky.social · last yr.

james surowiecki has discovered where the completely fabricated trump tariff rate has come from for each country "...for every country, they just took our trade deficit with that country and divided it by the country's exports to us."

Just figured out where these fake tariff rates come from. They didn't actually calculate tariff rates + non-tariff barriers, as they say they did. Instead, for every country, they just took our trade deficit with that country and divided it by the country's exports to us. So we have a $17.9 billion trade deficit with Indonesia. Its exports to us are $28 billion. $17.9/$28 = 64%, which Trump claims is the tariff rate Indonesia charges us. What extraordinary nonsense this is.
Prof Christina Pagel@chrischirp.bsky.social · 2y ago

🧵"So this is how liberty dies..." Trump’s first 3 weeks have been a relentless flood of actions. It's incredibly hard to keep up. I’ve gone through 69 actions & mapped out the pattern - showing how they fall within 5 broad domains consistent with authoritarian states 1/9

This is a venn diagram showing how 69 Trump actions map onto domains covering: undermining democratic institutions; suppressing dissent and media; dismantling social protections; attacking science and education; destabilising the global order. A table version is available here https://docs.google.com/spreadsheets/d/1LZN7QnbSyFfUZJG8Sn1MWpK0VnfBtb0OSyZ1jxP3xBk/edit?usp=sharing
Kelly Zamudio@kzutaustin.bsky.social · 2y ago

Hello All, plz share. Last call for applications for a post-doc position in our lab to study immune function in frogs infected with the fungal pathogen Bd. Deadline is Feb 1, reviews will begin soon after. zamudiolab.org/2024/12/17/p...

Post-Doc position in the KZLab! Immune responses to pathogen infections in frogs

We are looking for an NSF-funded post-doc in our lab in the Department of Integrative Biology at the University of Texas at Austin. The work will examine immune mechanisms that potentially underlie…

zamudiolab.org

Kelly Zamudio@kzutaustin.bsky.social · 2y ago

Hey All, plz repost, and share with grads, post-docs and disease folks! We are hiring a post-doc to work on mechanisms of immune responses of frog hosts to Bd infections. Deadline is February 1, 2025. Details for the position can be found at the link below. 🐸🐸🐸 zamudiolab.org/2024/12/17/p...

Post-Doc position in the KZLab! Immune responses to pathogen infections in frogs

We are looking for an NSF-funded post-doc in our lab in the Department of Integrative Biology at the University of Texas at Austin. The work will examine immune mechanisms that potentially underlie…

zamudiolab.org