In this recent study, Pei Xin Boon from @liu.se and colleagues observed that differential negative dominance by #KCNA2 variants associated with global developmental delay suggests KCNA2 #haploinsufficiency in humans🧬 🧠 Read the #research: 📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

It's either a two-step process or there are two populations of channels in the membrane

We all look forward to attending hashtag#bps2026 next week, and supporting our Biophysical Society in San Francisco 🌉 ! Here are the lab's presentations this year:

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.

bioRxivpreprint@biorxivpreprint.bsky.social · 9mo ago

CUT&ID for simultaneous profiling of protein-DNA and protein-protein interactions https://www.biorxiv.org/content/10.64898/2025.12.11.693662v1

To all trainees interested in channels and transporters: the joint FEBS/EMBO course will go ahead in Erice, Italy from May 13-19 2026: network.febs.org/posts/new-jo... Further details to come soon. Please share and repost.

"Hearts and Minds" achievement unlocked! Our lab is now receiving simultaneous funding by the Swedish Heart-Lung Foundation ❤️ and the Swedish Brain Foundation 🧠! (been waiting all year to be able to say this)

2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026. 🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others. 💡 Submit abstracts by the 26th of September, 2025: lnkd.in/eDhPUVKd 💻 More info: lnkd.in/eJw9pfMz

Very excited to share our most recent work on using de novo design to custom engineer a small peptide that can restore proper sodium channel function in disease … to be able to “write” proteins to do whatever we want them to do, is just remarkable …

Cell - a Cell Press journal@cp-cell.bsky.social · last yr.

Now online! De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy

SOX2 and NR2F1 cooperate to make #neurons in the #Thalamus for visual input from the #retina #DevBio journals.biologists.com/bio/article/... ‪ @biologyopen.bsky.social In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social Driven by Linda Serra and @annanordin.bsky.social

SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus

Summary: The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans.

journals.biologists.com

Glass of tequila and a play through of Pet Sounds. RIP Brian Wilson, on a very Californian evening in southern Sweden.

Out now at Nat Comm: "A rich conformational palette 🎨 underlies human CaV2.1-channel availability" 1. VSD-I activation triggers transmitter release 2. VSD-I conversion causes VDI & contributes to plasticity 3. CaV2.1 channels have several conformations at Vrest #neuroskyence #CACNA1A rdcu.be/ei0Tm

A rich conformational palette underlies human CaV2.1-channel availability

Nature Communications - CaV2.1 channels are critical for neuronal communication. Here, authors showed they undergo electrically-evoked molecular movements which (1) eventually trigger...

rdcu.be

An immensely interesting seminar with plot twists is going to take place next Tuesday! 🕵 ⚡ Join the exciting talk of @antoniospantazis.bsky.social titled "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant". 🫀 to connect: lnkd.in/evCC__x7

It will be turbulent in the next worldwide sodium channel seminar: @antoniospantazis.bsky.social will explain why "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant" Tuesday April 29th. Visit www.sodiumchannelseminars.org for link and infos. #sodiumchannel

New paper blue-torial! On the surface, it's a new ⚡Nav1.5 #channelopathy causing 🫀 familial cardiac #arrhythmia. But our story has enough plot twists to rival MK Shyamalan! www.jmcc-online.com/article/S002... 🧵 1/11

Clinical and electrophysiological characterization of a SCN5A gain-of-function mutation associated with CPVT-like arrhythmia

The present study aimed to characterize the SCN5A variant I1333V, found in five families with a history of suspected catecholaminergic polymorphic ventricular tachycardia (CPVT). SCN5A encodes the por...

jmcc-online.com

Spread the news! Grants available to recruit scientists from outside of Europe to Sweden 🇸🇪 🧠 Please re-post.

New grant for recruiting researchers active outside Europe

In mid-April, the Swedish Research Council will issue a call for grants of 2 million SEK to enable Swedish higher education institutions and other research organisations to recruit prominent researche...

vr.se