“Nothing in life is as important as you think it is while you are thinking about it". – Daniel Kahneman
Avezov lab
@avezovlab.bsky.social
Exploring brain cell biology, organelle dynamics & proteostasis. 📍University of Cambridge @cambridge-uni.bsky.social | @UKDRI | 🔬developing live cell biosensing tech
Thrilled to see our paper now featured on the cover, as part of the highlight “Neurodegeneration Through the Lens of Selective Brain Cell Vulnerability.” advanced.onlinelibrary.wiley.com/share/4YDKRX...
Avezov lab@avezovlab.bsky.social · 4mo ago🚨📜Our new paper out in @AdvSciNews: ER shape matters for neuronal health - disrupting ER continuity halts neuro-firing as it slows Ca2+ store refill, explaining selective neuronal vulnerability to ER problems in neurodegeneration 🧠 a thread to follow advanced.onlinelibrary.wiley.com/doi/10.1002/...
My choice this week in @science.org Roman Polishchuk, Franck Perez and collaborators A coordinated transcriptional program controls de novo Golgi biogenesis link.springer.com/article/10.1...
🧠 New paper, Avezov lab @ukdri.ac.uk: Problems with cell’s ‘plumbing’ linked to signalling issues in neurodegenerative conditions. The geometry of the endoplasmic reticulum can cause issues with the supply of calcium in neurons www.clinical-neuroscience.cam.ac.uk/news/problem...
How does the cell's transport network go wrong in neurodegenerative conditions? 🧠 New research led by @avezovlab.bsky.social (UK DRI at @cneurodept.bsky.social ) reveals new insight and a potential therapeutic avenue 👉 ukdri.ac.uk/news-and-eve...
Last chance to apply for Associate or Senior Editor in Neuroscience and Regenerative Medicine for Science magazine @science.org jobs.sciencecareers.org/job/679035/a...
Associate or Senior Editor - Washington D.C., Cambridge, UK job with American Association for the Advancement of Science | 679035
Join the editorial team at Science! We are seeking a full time Associate or Senior Editor
jobs.sciencecareers.org
Congratulation to Dr. Daniel Maddison on his @alzheimersresearchuk.org award! This is a hugely exciting research direction, and there is no better scientist to lead it — we are delighted to host this project in the lab🧠 @cneurodept.bsky.social @ukdri.ac.uk www.linkedin.com/posts/daniel...
Alzheimer's Society funding announcement DRLs | Daniel Maddison | 14 comments
I am thrilled and honoured to share that I have been awarded an Alzheimer’s Society Postdoctoral Fellowship. Over the next three years, hosted in the Edward Avezov lab, UK Dementia Research Institute,...
linkedin.com
Congratulation to Dr. Daniel Maddison on his @alzheimersresearchuk.org award! This is a hugely exciting research direction, and there is no better scientist to lead it — we are delighted to host this project in the lab🧠 @cneurodept.bsky.social @ukdri.ac.uk www.linkedin.com/posts/daniel...
Alzheimer's Society funding announcement DRLs | Daniel Maddison | 14 comments
I am thrilled and honoured to share that I have been awarded an Alzheimer’s Society Postdoctoral Fellowship. Over the next three years, hosted in the Edward Avezov lab, UK Dementia Research Institute,...
linkedin.com
simple it wasn’t :)
Jonny Nixon-Abell@abelljonny.bsky.social · 2mo agoWow! It was not simple, but we managed to package and ship 3 confocal microscopes from @thecimr.bsky.social to the Sena Institute of Technology in Penyi, Ghana. A massive thanks to all the amazing people at CIMR who helped out, and can’t wait to see these scopes running and producing data at SIT!
Researchers have identified superparamagnetic macrophages in the livers of rock pigeons to be crucial for magnetic sensing. The finding uncovers an unexpected role for immune cells in sensory perception and may fundamentally change our understanding of animal navigation. https://scim.ag/4nTQ3nq
These fields are moving fast, with real momentum and discovery ahead — whoever takes this on will have plenty to be excited about!
Stella Hurtley@smhsci.bsky.social · 3mo ago@science.org is looking for a new editor to look after regenerative medicine and neuroscience submissions. Come join us! Check out this Associate or Senior Editor opportunity recruiting.ultipro.com/AME1123ASEM/...
Just published in @science.org The oscillatory biology of sleep: Linkage to dementia | Science www.science.org/doi/10.1126/...
The oscillatory biology of sleep: Linkage to dementia
During wakefulness, neuromodulators operate largely independently to support behavior and cognition. By contrast, sleep reorganizes their activity into a coordinated brain rhythm. During sleep, the ma...
science.org
The more we learn about #glycotime, the more dramatic will be our revisions to textbooks on such basic principles as protein trafficking and organelle privileges www.nature.com/articles/s41...
Nuclear N-glycosylation maintains H3K9me3 heterochromatin and genomic stability - Nature Cell Biology
Tang, Dai, Qing, Zhang and colleagues describe a role for N-glycosylation in the nucleus: N-glycans modify inner nuclear membrane proteins, and the modification is implicated in the maintenance of H3K...
nature.com
My choice last week in @science.org Deltaviruses spread through a viral Trojan Horse 10.1016/j.cell.2026.01.037
This mesmerizing timelapse captures the nonstop motion inside an animal cell. Red/orange streaks are the growing ends of microtubules, tiny “highways” that can rapidly assemble and disassemble to move proteins & other molecules within the cell. 📸: Andy Moore, HHMI’s Janelia Research Campus
🧪 Biomedical Picture of the Day from the Presynapse -
Biomedical Picture of the Day BPoD@bpodaily.bsky.social · 4mo agoImportin β1's role in presynaptic vesicles of hippocampal neurons for spatial memory 📷 @philipfreund.bsky.social @npanayotis.bsky.social et al @weizmanninstitute.bsky.social in @science.org Signaling ➡️ bpod.org.uk/archive/2026... with John Ankers
🚨📜Our new paper out in @AdvSciNews: ER shape matters for neuronal health - disrupting ER continuity halts neuro-firing as it slows Ca2+ store refill, explaining selective neuronal vulnerability to ER problems in neurodegeneration 🧠 a thread to follow advanced.onlinelibrary.wiley.com/doi/10.1002/...
Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability
The ER's continuous tubular network is maintained by ER-shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of ...
advanced.onlinelibrary.wiley.com
🚨📜Our new paper out in @AdvSciNews: ER shape matters for neuronal health - disrupting ER continuity halts neuro-firing as it slows Ca2+ store refill, explaining selective neuronal vulnerability to ER problems in neurodegeneration 🧠 a thread to follow advanced.onlinelibrary.wiley.com/doi/10.1002/...
Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability
The ER's continuous tubular network is maintained by ER-shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of ...
advanced.onlinelibrary.wiley.com
🧪 Collective cognition in weaver ants? wis-wander.weizmann.ac.il/space-physic...
High-Rise Living: The Tiny Engineers that Build with Their Bodies - Weizmann Wonder Wander - News, Features and Discoveries
Weizmann Institute scientists reveal how weaver ants "think" as a group and link their bodies together to "zipper" the treetops
wis-wander.weizmann.ac.il
🚨 #BSRA2026 is LIVE! Registration now open for our 75th Annual Meeting 📍 Oxford (Keble College) Great science, great people, and some special 75th year surprises 👀 Tag someone who should be there! 🔗 meetinghand.com/e/75th-asm-o...
🧪 ‘Truly spectacular’ drug for sleeping sickness
Ada Palmer@adapalmer.bsky.social · 4mo agoEuropean regulators have approved acoziborole, a new treatment for sleeping sickness that cures the disease with a single oral dose. The drug replaces complex regimens requiring hospitalisation, spinal taps and weeks of monitoring. buff.ly/KX3Ld2B #ShareGoodNewsToo
Excited to share our new preprint on how membranes shape SNARE TMDs! www.biorxiv.org/content/10.6...
Please check out our newest work on fluorogenic speed imager probes, in which we combine the strengths of speed-optimized imagers and fluorogenic imagers. #SuperResolution #DNAPAINT #microscopy www.biorxiv.org/content/10.6...
Huilun Helen Wang, Shengyi Sun, Ling Qi et al. serendipitously discover that mouse models expressing a fatal ERAD pathway mutation in SEL1L are rescued by alternative-splicing-mediated exclusion of the defective region link.springer.com/article/10.1...
Functional rescue of a disease-linked ERAD pathway mutation via alternative splicing - The EMBO Journal
ER-associated degradation (ERAD) targets misfolded proteins in the endoplasmic reticulum (ER) for proteasomal degradation. Mutations in its most conserved branch involving the SEL1L-HRD1 complex cause...
link.springer.com
🚨📰Now online in its full form www.nature.com/articles/s41...
FidlTrack: high-fidelity structure-aware single particle tracking resolves intracellular molecular motion in organelles sensing APP processing - Nature Communications
Tracking fast molecules in crowded organelles is error-prone, obscuring dynamic processes like Alzheimer’s secretase activity or secretory sorting. Here, authors present FidlTrack, a structure-aware m...
nature.com
Avezov lab@avezovlab.bsky.social · 6mo agoOur new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule rdcu.be/e3Ris
🚨📰Now online in its full form www.nature.com/articles/s41...
FidlTrack: high-fidelity structure-aware single particle tracking resolves intracellular molecular motion in organelles sensing APP processing - Nature Communications
Tracking fast molecules in crowded organelles is error-prone, obscuring dynamic processes like Alzheimer’s secretase activity or secretory sorting. Here, authors present FidlTrack, a structure-aware m...
nature.com
Avezov lab@avezovlab.bsky.social · 6mo agoOur new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule rdcu.be/e3Ris
For our annual alumni newsletter, Sean Munro reflected on his time at the LMB, including how opportunity and curiosity have shaped his group’s research into the Golgi apparatus and his tenure as Head of Division for @cellbiol-mrclmb.bsky.social Watch the interview: youtu.be/xFGb7_RmO9c
From the scientist's view: a conversation with Sean Munro
YouTube video by MRC Laboratory of Molecular Biology
youtu.be