Barbara Schraml

@barbaraschraml.bsky.social

Immunologist, with a passion for dendritic cells, neonatal immunity and immune development. @schraml-lab.de

2/2 This cDC1 state also emerges in germ-free mice, showing that it does not require microbial stimulation, and remains responsive to dietary manipulation in adults. Huge congratulations and thanks to first authors Ramin Shakiba and Doğuş Altunöz, and to all our co-authors and collaborators!

1/2 Our paper is out! We identify an IFNγ-driven circuit that relays cues from solid, grain-based chow to splenic cDC1 at weaning, inducing an immunogenic maturation state that promotes cytotoxic CD8⁺ effector-like T cells and shapes food-antigen-specific CD8⁺ T cells. rdcu.be/fxLmt

Peri-weaning, diet-induced activation of an IFNγ-mediated regulatory circuit promotes cDC1 maturation and CD8+ T cell differentiation

Nature Communications - Dendritic cells (DC) regulate CD8+ T cell differentiation to maintain a balance between pathogen protection and allergen tolerance, but how this balance may be enforced...

rdcu.be

🚨 Dedicated BSky account for EMDS2025 launched Please share far and wide. Follow @emds2025.bsky.social for all updates on the EMDS2025: Scotland Edition We have an amazing line up of speakers and are excited to welcome all of you to bonnie Scotland in September! @britsocimm.bsky.social

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Welcome to the BSky account for EMDS2025. Please follow us to hear about updates & deadlines for EMDS2025: Scotland Edition. Check out www.emds2025.com for full details - registration will open soon. We look forward to welcoming you all to the wonderful city of Edinburgh in September.